Results 31 to 40 of about 10,640,595 (395)
Role of IL-33 in inflammation and disease [PDF]
, 2011 Interleukin (IL)-33 is a new member of the IL-1 superfamily of cytokines that is expressed by mainly stromal cells, such as epithelial and endothelial cells, and its expression is upregulated following pro-inflammatory stimulation.
Miller, Ashley M.
core +3 more sources
Modulating Th2 Cell Immunity for the Treatment of Asthma [PDF]
Frontiers in Immunology, 2021 It is estimated that more than 339 million people worldwide suffer from asthma. The leading cause of asthma development is the breakdown of immune tolerance to inhaled allergens, prompting the immune system's aberrant activation. During the early phase, also known as the sensitization phase, allergen-specific T cells are activated and become central ...
Beatriz León, André Ballesteros-Tato
openaire +3 more sources
Turkish Archives of Otorhinolaryngology, 2015 Objective:With regard to the correlation between T helper1/T helper2 (Th1/Th2) cell balance and 1α,25-dihydroxyvitamin D3, active metabolite of vitamin D, we studied Th1/Th2 cell balance by measuring levels of the cytokines interleukin (IL)-4, IL-10 and ...
Erol Keleş +5 more
doaj +1 more source
Genetic analysis of differentiation of T-helper lymphocytes [PDF]
Genetics and Molecular Research 2 (2012) 972-987, 2013 In the human immune system, T-helper cells are able to differentiate into two lymphocyte subsets: Th1 and Th2. The intracellular signaling pathways of differentiation form a dynamic regulation network by secreting distinctive types of cytokines, while differentiation is regulated by two major gene loci: T-bet and GATA-3.
arxiv +1 more source
Crucial Role of MLL for the Maintenance of Memory T Helper Type 2 Cell Responses [PDF]
, 2006 SummaryThe Mixed-Lineage Leukemia (MLL) gene, a mammalian homolog of the Drosophila trithorax, is implicated in regulating the maintenance of Hox gene expression and hematopoiesis.
Hasegawa, Akihiro +7 more
core +1 more source
Resting respiratory tract dendritic cells preferentially stimulate T helper cell Type 2(Th2) responses and require obligatory cytokine signals for induction of Th1 immunity [PDF]
, 1998 Consistent with their role in host defense, mature dendritic cells (DCs) from central lymphoid organs preferentially prime for T helper cell type 1 (Th1)-polarized immunity.
Holt, P.G. +6 more
core +2 more sources
Thymic stromal lymphopoietin drives the development of IL-13+ Th2 cells
Proceedings of the National Academy of Sciences of the United States of America, 2018 Significance T helper 2 (Th2) cells are defined by their ability to produce the hallmark cytokine IL-4. However, to mediate allergic inflammation in tissues, Th2 cells must secrete additional cytokines including IL-13 and IL-5.
S. Ochiai +10 more
semanticscholar +1 more source
Frontiers in Immunology, 2018 Antigen-primed T cells respond to restimulation much faster than naïve T cells and form the cellular basis of immunological memory. The formation of memory Th2 cells starts when naïve CD4 T cells are transformed into effector Th2 cells and is completed ...
Atsushi Onodera +3 more
doaj +1 more source
Science Translational Medicine, 2019 Sodium chloride induces and amplifies human TH2 cell responses, potentially shaping the atopic skin microenvironment. Salting T cells’ game Sodium chloride can encourage TH17 differentiation in CD4 T cells. Matthias et al.
J. Matthias +21 more
semanticscholar +1 more source
The transcriptional repressor Bcl6 controls the stability of regulatory T cells by intrinsic and extrinsic pathways [PDF]
, 2015 Foxp3(+) regulatory T (Treg) cells are essential to maintain immune homeostasis, yet controversy exists about the stability of this cell population. Bcl6-deficient (Bcl6(-/-) ) mice develop severe and spontaneous T helper type 2 (Th2) inflammation and ...
Dent, Alexander L. +5 more
core +1 more source