Results 1 to 10 of about 149,005 (187)

The value of DNA repair gene and TP53 co-mutation in predicting the response of non-small cell lung cancer to immunotherapy [PDF]

Discover Oncology
Background While mutations in DNA repair gene (DDR) or TP53 alone have been linked to favorable outcomes in immunotherapy, their co-mutations may not have the same effect.
Bin Ye, Chunzhi Wu, Xiaoying Quan, Xiaoli Jia, Lin Yao, Lei Lei, Xiaoyan Chen   +6 more
doaj   +2 more sources

Translational Aspects of DNA Damage Repair in Optimizing Cancer Chemotherapy [PDF]

Advanced Genetics
The DNA Damage Repair (DDR) signaling pathway serves as a crucial molecular hub that regulates chemotherapy efficacy, offering significant translational value in the field of precision oncology.
Anqi Lin, Jinyue He, Aimin Jiang, Jian Zhang, Quan Cheng, Hengguo Zhang, Wenjun Mao, Peng Luo   +7 more
doaj   +2 more sources

Pathogenic variation in human DNA damage repair genes was originated from the evolutionary process of modern humans [PDF]

Genes and Diseases
DNA damage repair (DDR) genes play critical roles in maintaining genome stability. However, they are prone to genetic variation, of which pathogenic variation (PV) is a predisposing factor for high risk of cancer development in modern humans. Knowing the
Jiaheng Li, Bojin Zhao, Zixin Qin, Si Hoi Kou, Jia Sheng Chian, Fengxia Xiao, Huijun Lei, Stephanie Andaluz, Jun He, Siddharth Sinha, Xiaowei Mao, San Ming Wang   +11 more
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Exploring Quantum Sensing Potential for Systems Applications

IEEE Access, 2023
The current rise of quantum technology is compelled by quantum sensing research. Thousands of research labs are developing and testing a broad range of sensor prototypes.
Boris Kantsepolsky, Itzhak Aviv, Roye Weitzfeld, Eliyahu Bordo   +3 more
doaj   +1 more source

DNA Damage Repair Profiles Alteration Characterize a Hepatocellular Carcinoma Subtype With Unique Molecular and Clinicopathologic Features

Frontiers in Immunology, 2021
Hepatocellular carcinoma (HCC) is one of the most common malignancies and displays high heterogeneity of molecular phenotypes. We investigated DNA damage repair (DDR) alterations in HCC by integrating multi-omics data.
Peng Lin, Rui-zhi Gao, Rong Wen, Yun He, Hong Yang   +4 more
doaj   +1 more source

Multi-omics analyses unravel DNA damage repair-related clusters in breast cancer with experimental validation

Frontiers in Immunology, 2023
BackgroundAs one of the most common malignancies worldwide, breast cancer (BC) exhibits high heterogeneity of molecular phenotypes. The evolving view regarding DNA damage repair (DDR) is that it is context-specific and heterogeneous, but its role in BC ...
Peng Liu, Xinpei Deng, Huamao Zhou, Jindong Xie, Yanan Kong, Yutian Zou, Anli Yang, Xing Li   +7 more
doaj   +1 more source

Integration of bulk RNA sequencing and single-cell analysis reveals a global landscape of DNA damage response in the immune environment of Alzheimer’s disease

Frontiers in Immunology, 2023
BackgroundWe developed a novel system for quantifying DNA damage response (DDR) to help diagnose and predict the risk of Alzheimer’s disease (AD).MethodsWe thoroughly estimated the DDR patterns in AD patients Using 179 DDR regulators.
Yongxing Lai, Yongxing Lai, Han Lin, Manli Chen, Xin Lin, Xin Lin, Lijuan Wu, Lijuan Wu, Yinan Zhao, Yinan Zhao, Fan Lin, Fan Lin, Chunjin Lin, Chunjin Lin   +13 more
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DNA Damage Response and Repair Gene Alterations Increase Tumor Mutational Burden and Promote Poor Prognosis of Advanced Lung Cancer

Frontiers in Oncology, 2021
DNA damage response and repair (DDR) gene alterations increase tumor-infiltrating lymphocytes, genomic instability, and tumor mutational burden (TMB).
Jiawei Dai, Minlin Jiang, Minlin Jiang, Kan He, Hao Wang, Hao Wang, Peixin Chen, Peixin Chen, Haoyue Guo, Haoyue Guo, Wencheng Zhao, Wencheng Zhao, Hui Lu, Yayi He, Yayi He, Caicun Zhou   +15 more
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Patient-Level DNA Damage Repair Pathway Profiles and Anti-Tumor Immunity for Gastric Cancer

Frontiers in Immunology, 2022
DNA damage repair (DDR) comprises the detection and correction of alterations in the chemical structure of DNA. The dysfunction of the DDR process has been determined to have important implications for tumor carcinogenesis, malignancy progression ...
Shenghan Lou, Yufei Wang, Jian Zhang, Xin Yin, Yao Zhang, Yimin Wang, Yingwei Xue   +6 more
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Henryk Sienkiewicz’s output and literary censorship in the DDR

Acta Universitatis Lodziensis. Folia Litteraria Polonica, 2020
Works by Henryk Sienkiewicz, a Polish writer and the winner of the 1905 Nobel Prize for Literature, were subjected to verification by the DDR’s censorship apparatus several times. Censors considered his novellas which discussed 19th-century social issues
Marek Rajch
doaj   +1 more source