Results 141 to 150 of about 149,069 (251)
Experimental Physiology, EarlyView.Abstract Space exploration involves many dangers including galactic cosmic radiation (GCR). This class of radiation includes high‐energy protons and heavy ionizing ions. NASA has defined GCR as a carcinogenic risk for long‐duration space missions. To date, no clear strategy has been developed to counter chronic GCR exposure.
Siena Edwards +3 more
wiley +1 more source
Clinical Pharmacology &Therapeutics, Volume 119, Issue 3, Page 618-628, March 2026.We present model‐informed selection of the recommended dose for expansion (RDE) of investigational oral ATR inhibitor tuvusertib, by integrating clinical pharmacokinetics (PK), pharmacodynamics (PD), and safety data from DDRiver Solid Tumors 301 trial Part A1 (NCT04170153).
Jatinder Kaur Mukker +20 more
wiley +1 more source
Cell Communication and SignalingInitially, it was believed that glycolysis and DNA damage repair (DDR) were two distinct biological processes that independently regulate tumor progression. The former metabolic reprogramming rapidly generates energy and generous intermediate metabolites,
Fengyao Sun +6 more
doaj +1 more source
MedComm – Oncology, Volume 5, Issue 1, March 2026.Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang +7 more
wiley +1 more source
Salt‐Freshwater Mixing and Submarine Groundwater Discharge in Sloping Unconfined Tidal Aquifers
Geophysical Research Letters, Volume 53, Issue 3, 16 February 2026.Abstract Previous studies have revealed the groundwater flow and salt transport in unconfined coastal aquifers in response to numerous factors. However, previous studies assumed a flat aquifer base, and it is unclear how a sloping aquifer base would affect the subsurface flow and salinity distributions.
Chengji Shen +5 more
wiley +1 more source
Advanced Materials Technologies, Volume 11, Issue 3, 5 February 2026.This study demonstrates a cost‐effective hybrid nanofiller approach for developing conductive polyamide 6 filaments via melt spinning. Branched carbon nanotubes combined with carbon black create synergistic networks where spherical CB particles bridge aligned CNTs, maintaining electrical pathways during fiber drawing.
Müslüm Kaplan +3 more
wiley +1 more source
Advanced Science, Volume 13, Issue 7, 3 February 2026.Glutamine deprivation triggers ACSL5 upregulation in tumor cells, sustaining their viability via dual metabolic rewiring programs. ACSL5 enhances glycolysis by relieving p53's inhibition of PGAM1 while also sustaining mitochondrial respiration and TCA cycle flux through promoting IDH2 dimerization.
Shuai Tian +11 more
wiley +1 more source
AAV Assembled Capsids Are Produced in Cells Blocked From Cell Cycle Progression
Biotechnology and Bioengineering, Volume 123, Issue 2, Page 273-286, February 2026.ABSTRACT Adeno‐associated virus (AAV) is a promising delivery system for gene therapy. However, current manufacturing of AAV suffers from very low yields compared to other biotherapeutics. The AAV dose per patient ranges between 1011and 1015 viral genomes (vg), requiring an average of 10 to 30 L production/dose.
Alaka Mullick +8 more
wiley +1 more source
Chemistry &Biodiversity, Volume 23, Issue 2, February 2026.Untargeted metabolic profiling of three body tissues from Holothuria cinerascens in South Africa using 1H‐NMR and UPLC–QTOF–MS revealed distinct tissue‐specific and seasonal metabolic variations, with the body wall and gut/mesentery exhibiting high metabolite diversity.
Cassandra Upton +3 more
wiley +1 more source
Cancer Reports, Volume 9, Issue 2, February 2026.ABSTRACT Background Acute myeloid leukemia (AML) is a prevalent hematologic malignancy in adults, marked by clonal disorders in hematopoietic cells, rapid progression, and genetic heterogeneity. The WRAP53 gene, which is associated with genomic stability due to its involvement in activities, such as DNA repair, TP53 regulation, and association with ...
Renan Brito Gadelha +14 more
wiley +1 more source