Results 151 to 160 of about 149,069 (251)

CEACAM6 silencing suppresses tumour growth and sensitises cholangiocarcinoma to cisplatin

Clinical and Translational Discovery, Volume 6, Issue 1, February 2026.
CEACAM6 has the potential to become a novel and independent prognostic biomarker in cholangiocarcinoma (CCA). Silencing CEACAM6 can inhibit CCA tumour growth and significantly enhance the chemosensitivity to cisplatin. This chemo‐sensitising effect is mediated through the disruption of ribosome biogenesis and impairment of DNA damage repair.
Shi‐Jia Dai, Jiang‐Qi Tan, Jia‐Qi Guo, Ya‐Nan Zhou, Teng Huang, Hao‐Lin Jiang, Yang Liu, Li‐Wei Dong, Zhen‐Gang Yuan   +8 more
wiley   +1 more source

Activation of the ATM-Chk2 DNA damage response pathway by Newcastle disease virus enhances viral replication. [PDF]

Vet Res
Yan W, Dong C, Liu X, Li H, Peng J, Jiang F, Li H, Stoeger T, Wajid A, Dodovski A, Mingala CN, Andreychuk DB, Yin R.   +12 more
europepmc   +1 more source

Electrical and Rheological Behavior of Melt‐Spun Polyamide 6 via Synergistic SWCNT/Carbon Black Networks

Macromolecular Materials and Engineering, Volume 311, Issue 2, February 2026.
Hybrid SWCNT/carbon black nanofillers in melt‐spun PA6 filaments demonstrate synergistic network preservation during fiber drawing. Carbon black particles bridge gaps between aligned SWCNTs, maintaining electrical resistivity of ∼102–104 Ω·cm despite processing‐induced deformation.
Müslüm Kaplan, Beate Krause, Norbert Smolka, Ines Kuehnert   +3 more
wiley   +1 more source

Oxidative Stress: Molecular Mechanisms, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Oxidative stress occurs when the reactive oxygen species (ROS) production overwhelms the ROS scavenging, which lead to genomic instability, epigenetic regulation, proteostasis imbalance, and lipid peroxidation, subsequently causing the occurrence and development of numerous diseases. ABSTRACT Although the physiological level of reactive oxygen species (
Yi Qin, Chen Qian, Wenhao Li, Qihan Wang, Qifeng Sheng, Zheqing Chen, Wei Zhang, Wenming Li, Gaoran Ge, Zhanjun Yan, Dechun Geng   +10 more
wiley   +1 more source

Scattering from `Babinet' particles (or not…): spherical particles made up of spheres and spherical particles with spherical voids

Journal of Applied Crystallography, Volume 59, Issue 1, Page 59-68, February 2026.
Small‐angle scattering form factors of composite particles built from either embedded spheres or randomly distributed voids within a sphere are obtained by Monte Carlo simulations, and analytical expressions that reproduce the simulations are derived.The small‐angle scattering form factors of two classes of composite particles with contrasting internal
Jan Skov Pedersen, Thea Lykkegaard Møller, Milena Corredig   +2 more
wiley   +1 more source

Obesity and cancer: Relevance of DNA damage response. [PDF]

Transl Oncol
Deshmukh B, Ajay AK, Bhat MK.
europepmc   +1 more source

Rapamycin Exerts Its Geroprotective Effects in the Ageing Human Immune System by Enhancing Resilience Against DNA Damage

Aging Cell, Volume 25, Issue 2, February 2026.
Using in vitro DNA damage assays in human T cells, ex vivo profiling of aged immune subsets and a small placebo‐controlled in vivo study, authors show that low‐dose rapamycin, a potent life‐extending mTOR inhibitor, enhances resilience against DNA damage in the human immune system.
Loren Kell, Eleanor J. Jones, Nima Gharahdaghi, Daniel J. Wilkinson, Kenneth Smith, Philip J. Atherton, Anna K. Simon, Lynne S. Cox, Ghada Alsaleh   +8 more
wiley   +1 more source

DNA damage induced by HIV-1 Vpr triggers epigenetic remodeling and transcriptional programs to enhance virus transcription and latency reactivation. [PDF]

PLoS Biol
Saladino N, Leavitt E, Wong HT, Ji JH, Ebrahimi D, Salamango DJ.   +5 more
europepmc   +1 more source

Aging of the Hematopoietic System: Mechanisms, Consequences, and Systemic Interactions

Aging Cell, Volume 25, Issue 2, February 2026.
Hematopoietic aging arises from intrinsic stem‐cell decline and bone‐marrow niche dysfunction, leading to myeloid skewing, immunosenescence, and clonal hematopoiesis. These changes drive systemic inflammation and multi‐organ disease, which in turn further disrupt the bone‐marrow niche and hematopoietic stem cell (HSC) function, creating a vicious cycle
Masashi Miyawaki, Seiji Hashimoto, Sumito Ogawa, Yoshitaka Kase   +3 more
wiley   +1 more source

The DDR-immune fitness score: a biomarker for guiding parp and immunotherapy synergy in extensive-stage small cell lung cancer. [PDF]

Front Oncol
Zhang Y, Chen X, Wang D, Zhou X, Wang Y, Zhang G, Liu X.   +6 more
europepmc   +1 more source