Results 31 to 40 of about 149,069 (251)
Frontiers in Immunology, 2023 BackgroundAberrant DNA damage repair (DDR) is one of the hallmarks of tumors, and therapeutic approaches targeting this feature are gaining increasing attention.
Xiaoqing Xiang +6 more
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Targeting DNA damage response deficiency in the treatment of breast cancer [PDF]
Zhongguo aizheng zazhi, 2022 DNA damage response (DDR) deficiency has been one of the emerging targets in treating breast cancer in recent years. The DDR pathway is essential for the identification, signal transduction and repair of DNA damage.
JIN Yizi, LIN Mingxi, ZHANG Jian
doaj +1 more source
Transitional justice and peacebuilding on the ground [PDF]
, 2012 Policy brief drawing on the research conducted as part of a grant from the US Institute of Peace (USIP 002-09F) on victim-centred approaches to justice and DDR ...
Martin-Ortega, Olga
core +1 more source
SWI/SNF and Asf1 independently promote derepression of the DNA damage response genes under conditions of replication stress. [PDF]
PLoS ONE, 2011 The histone chaperone Asf1 and the chromatin remodeler SWI/SNF have been separately implicated in derepression of the DNA damage response (DDR) genes in yeast cells treated with genotoxins that cause replication interference.
Laura V Minard +2 more
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Frontiers in Oncology, 2022 DNA damage repair (DDR) is essential for maintaining genome integrity and modulating cancer risk, progression, and therapeutic response. DDR defects are common among non-small lung cancer (NSCLC), resulting in new challenge and promise for NSCLC ...
Ling Li +9 more
doaj +1 more source
Risks from low dose/dose rate radiation: what an understanding of DNA damage response mechanisms can tell us [PDF]
, 2009 The DNA damage response (DDR) mechanisms represent a vital line of defense against exogenous and endogenous DNA damage to enhance two distinct outcomes, survival and the maintenance of genomic stability. The latter is critical for cancer avoidance.
Jeggo, Peggy A.
core +2 more sources
Role of DNA repair defects in predicting immunotherapy response
Biomarker Research, 2020 Defect in DNA damage response (DDR) is a common feature of cancer cells, which regulates tumor growth and therapeutic response. Recently, the approval of immune checkpoint blockade (ICB) for tumors with defective mismatch repair has paved the way for ...
Jing Zhang +2 more
doaj +1 more source
Function and Molecular Mechanism of the DNA Damage Response in Immunity and Cancer Immunotherapy
Frontiers in Immunology, 2021 The DNA damage response (DDR) is an organized network of multiple interwoven components evolved to repair damaged DNA and maintain genome fidelity.
Zu Ye +4 more
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Frontiers in ImmunologyBackgroundImpaired DNA damage response (DDR) can affect immune checkpoint inhibitors (ICI) efficacy and lead to heightened immune activation. We assessed the impact of pathogenic or likely pathogenic (P/LP) germline DDR mutations on ICI response and ...
Michael J. Dennis +9 more
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The Adenovirus E4orf4 Protein Provides a Novel Mechanism for Inhibition of the DNA Damage Response. [PDF]
PLoS Pathogens, 2016 The DNA damage response (DDR) is a conglomerate of pathways designed to detect DNA damage and signal its presence to cell cycle checkpoints and to the repair machinery, allowing the cell to pause and mend the damage, or if the damage is too severe, to ...
Anna Brestovitsky +4 more
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