Results 71 to 80 of about 149,069 (251)

A Smart Bio‐Battery Facilitates Diabetic Bone Defect Repair Via Inducing Macrophage Reprogramming and Synergistically Modulating Bone Remodeling Coupling

Advanced Functional Materials, EarlyView.
This research presents a novel implantable bio‐battery, GF‐OsG, tailored for diabetic bone repair. GF‐OsG generates microcurrents in high‐glucose conditions to enhance vascularization, shift macrophages to the M2 phenotype, and regulate immune responses.
Nanning Lv, Haifu Sun, Wenxiang Tang, Yonggang Li, Zhonglai Qian, Lihui Hong, Chong Chen, Hongye Li, Jiaxiang Bai, Yusen Qiao, Mingming Liu   +10 more
wiley   +1 more source

Pathogenic variants in human DNA damage repair genes mostly arose in recent human history

BMC Cancer
Background Genome stability is maintained by the DNA damage repair (DDR) system composed of multiple DNA repair pathways of hundreds of genes. Germline pathogenic variation (PV) in DDR genes damages function of the affected DDR genes, leading to genome ...
Bojin Zhao, Jiaheng Li, Siddharth Sinha, Zixin Qin, Si Hoi Kou, Fengxia Xiao, Huijun Lei, Tianhui Chen, Wenming Cao, Xiaofan Ding, San Ming Wang   +10 more
doaj   +1 more source

Invariance of the BFV-complex [PDF]

, 2010
The BFV-formalism was introduced to handle classical systems, equipped with symmetries. It associates a differential graded Poisson algebra to any coisotropic submanifold $S$ of a Poisson manifold $(M,\Pi)$.
Schaetz, Florian
core   +2 more sources

A Human Kidney Tubuloid Model of Repeated Cisplatin‐Induced Cellular Senescence and Fibrosis for Drug Screening

Advanced Healthcare Materials, EarlyView.
Replicating aging and senescence‐related pathophysiological responses in kidney organoids remains a significant challenge. Human adult renal tubular organoid, tubuloids, are successfully developed recapitulating cellular senescence that is the central pathophysiological mechanism of chronic kidney disease (CKD).
Yuki Nakao, Makiko Mori, Yuta Sekiguchi, Iori Morita, Ryota Shindoh, Shintaro Mandai, Tamami Fujiki, Hiroaki Kikuchi, Fumiaki Ando, Koichiro Susa, Takayasu Mori, Ayumi Suzuki, Yuji Nashimoto, Hirokazu Kaji, Yuma Waseda, Soichiro Yoshida, Yasuhisa Fujii, Eisei Sohara, Shinichi Uchida, Kensuke Miyake, Yutaro Mori   +20 more
wiley   +1 more source

Activity-promoting gaming systems in exercise and rehabilitation [PDF]

, 2011
Commercial activity-promoting gaming systems provide a potentially attractive means to facilitate exercise and rehabilitation. The Nintendo Wii, Sony EyeToy, Dance Dance Revolution, and Xbox Kinect are examples of gaming systems that use the movement of ...
Griffin, Murray, Impson, Rebecca, McCormick, Darren, Shawis, Teshk, Taylor, Matthew JD   +4 more
core   +1 more source

A Quantitative Printability Framework for Programmable Assembly of Pre‐Vascular Patterns via Laser‐Induced Forward Transfer

Advanced Healthcare Materials, EarlyView.
Laser‐Induced Forward Transfer (LIFT) is presented as a powerful micropatterning tool. An objective printability framework is developed to assess optimal printing parameter combinations. The technology is further explored for its ability to deterministically deposit microdroplets at predefined locations following CAD designs, enabling the patterning of
Cécile Bosmans, Núria Ginés Rodriguez, Ulisses Jesús Gutiérrez Hernández, David Fernandez Rivas, Marcel Karperien, Jos Malda, Liliana Moreira Teixeira, Riccardo Levato, Jeroen Leijten   +8 more
wiley   +1 more source

Opportunities of Semiconducting Oxide Nanostructures as Advanced Luminescent Materials in Photonics

Advanced Materials, EarlyView.
The review discusses the challenges of wide and ultrawide bandgap semiconducting oxides as a suitable material platform for photonics. They offer great versatility in terms of tuning microstructure, native defects, doping, anisotropy, and micro‐ and nano‐structuring. The review focuses on their light emission, light‐confinement in optical cavities, and
Ana Cremades, Pedro Hidalgo, David Maestre, Ruth Martínez‐Casado, Emilio Nogales, Beatriz Rodríguez, G. Cristian Vásquez, Bianchi Méndez   +7 more
wiley   +1 more source

Coordinated protein modules define DNA damage responses to carboplatin at single-cell resolution in human ovarian carcinoma models

Cell Reports Medicine
Summary: Tubo-ovarian high-grade serous carcinoma (HGSC), the most lethal gynecologic malignancy, initially responds to platinum-based chemotherapy, but due to frequent defects in the DNA damage response (DDR), most tumors develop resistance.
Jacob S. Bedia, Antonio Delgado-Gonzalez, Ying-Wen Huang, Veronica D. Gonzalez, Ionut-Gabriel Funingana, Zainab Rahil, Alyssa Mike, Alexis Lowber, Maria Vias, Alan Ashworth, James D. Brenton, Wendy J. Fantl   +11 more
doaj   +1 more source

Stable cellular senescence is associated with persistent DDR activation.

PLoS ONE, 2014
The DNA damage response (DDR) is activated upon DNA damage generation to promote DNA repair and inhibit cell cycle progression in the presence of a lesion.
Marzia Fumagalli, Francesca Rossiello, Chiara Mondello, Fabrizio d'Adda di Fagagna, Fabrizio d'Adda di Fagagna   +4 more
doaj   +1 more source

Peptide‐Induced Ferroelectricity in Charge‐Transfer Supramolecular Materials

Advanced Materials, EarlyView.
Bio‐inspired supramolecular charge‐transfer amphiphiles self‐assemble into nanoribbons in water, where peptide chirality‐induced symmetry breaking generates robust ferroelectricity across multiple systems. These water‐processable organic ferroelectrics also enhance neuronal outgrowth and electrophysiological maturity, offering a versatile strategy for ...
James V. Passarelli, Yang Yang, Cara S. Smith, Jing Hao, Dhwanit R. Dave, Ashwin Narayanan, Zaida Álvarez, Broderick K. Johnson, Kelly A. Marshall, Ivan Fithian, Hiroaki Sai, Ruomeng Qiu, Charlotte L. Stern, Liam C. Palmer, Evangelos Kiskinis, Samuel I. Stupp   +15 more
wiley   +1 more source