Results 11 to 20 of about 18,156 (205)

Structure-Guided Optimization and Biological Validation of 1,3,4-Thiadiazole-Based SIRT2 Inhibitors Reinforcing Channel Entrance Interactions. [PDF]

Drug Dev Res
ABSTRACT SIRT2, the cytoplasmic member of the sirtuin family, is generally acknowledged to promote cancer and contribute to the progression of various pathologies, including neurodegeneration, inflammation, obesity, and bacterial infection through the deacetylation of target substrates.
Aksel AB, Ozgencil F, Bakar-Ates F, Gunindi HB, Massarotti A, Ozkan E, Kaya SG, Gozelle M, Ozkan Y, Eren G.   +9 more
europepmc   +2 more sources

Corrosion Inhibition Effect of Substituted Thiadiazoles on Brass

International Journal of Electrochemical Science, 2011
The corrosion inhibition of thiadiazole derivatives for brass in natural seawater has been evaluated by potentiodynamic polarisation and electrochemical impedance spectroscopic techniques.
X. Joseph Raj, N. Rajendran
doaj   +1 more source

In vitro assessment of antimicrobial, antioxidant, and cytotoxic properties of Saccharin-Tetrazolyl and-Thiadiazolyl derivatives: the simple dependence of the pH value on antimicrobial activity [PDF]

, 2019
The antimicrobial, antioxidant, and cytotoxic activities of a series of saccharin-tetrazolyl and -thiadiazolyl analogs were examined. The assessment of the antimicrobial properties of the referred-to molecules was completed through an evaluation of ...
Andrade, Joana M., Cabral, Lília, Cristiano, Maria de Lurdes, Frija, Luís M. T., Ntungwe, Epole, Pombeiro, Armando J. L., Rijo, Patrícia, Sitarek, Przemysław, Toma, Monika, Śliwiński, Tomasz   +9 more
core   +1 more source

Synthesis and Characterization of Five, Sevene Heterocyclic Membered Rings

مجلة بغداد للعلوم, 2013
New compounds containing heterocyclic units have been synthesized. These compounds include 2-amino 5- phenyl-1,3,4-thiadiazole (1) as starting material to prepare the Schiff bases 2N[3-nitrobenzylidene -2 hydroxy benzylidene and 4-N,N-dimethyl ...
Baghdad Science Journal
doaj   +1 more source

Design, Synthesis, Anticancer Activity and Molecular Docking of New 1,2,3-Triazole-Based Glycosides Bearing 1,3,4-Thiadiazolyl, Indolyl and Arylacetamide Scaffolds

Molecules, 2022
New 1,3,4-thiadiazole thioglycosides linked to a substituted arylidine system were synthesized via heterocyclization via click 1,3-dipolar cycloaddition.
Hussein H. Elganzory, Fahad M. Alminderej, Mohamed N. El-Bayaa, Hanem M. Awad, Eman S. Nossier, Wael A. El-Sayed   +5 more
doaj   +1 more source

Preparation of some azo compounds by diazotization and coupling of 2- amino -5 – thiol -1,3,4- thiadizaole

مجلة بغداد للعلوم, 2015
2- amino -5- thiol-1,3,4- thiadiazole (S1) was prepared by cyclic locking of thiosemicarbazide in the presence of anhydrous sodium carbonate and CS2. diazotization of (S1) compound gave diazonium salt (S2) that reacts with different activated aromatic ...
Baghdad Science Journal
doaj   +1 more source

Synthesis, Characterization and Single Crystal X-ray Diffraction Analysis of Fused Triazolo/Thiadiazole Clubbed with Indole Scaffold

Crystals, 2023
The present synthetic strategy involves the synthesis of indolyl-triazolo-thiadiazole heterocyclic ring systems 8–13 from the condensation of 4-amino-5-(1H-indol-2-yl)-3H-1,2,4-triazole-3-thione 1 with the aromatic carboxylic acid derivatives 2–7 in ...
Mezna Saleh Altowyan, Matti Haukka, Saied M. Soliman, Assem Barakat, Saleh O. Alaswad, Ahmed T. A. Boraei, Emad M. Gad, Mohamed F. Youssef   +7 more
doaj   +1 more source

Synthesis and Bioactivities of Novel 1,3,4-Thiadiazole Derivatives of Glucosides

Frontiers in Chemistry, 2021
A series of novel 1,3,4-thiadiazole derivatives of glucosides were synthesized by the starting materials d-glucose and 5-amino-1,3,4-thiadiazole-2-thiol in good yields with employing a convergent synthetic route.
Meihang Chen, Xun Zhang, Daowang Lu, Hairong Luo, Zengyan Zhou, Xufeng Qin, Wenneng Wu, Guoping Zhang   +7 more
doaj   +1 more source

Synthesis of Oxadiazoles, Thiadiazoles and Triazoles Derived from Benzo[b]thiophene

Molecules, 2005
In this work 3-chloro-2-chlorocarbonylbenzo[b]thiophene (1) was prepared from cinnamic acid and then converted into the acid hydrazide 2. The azomethines 3a-e were prepared from the corresponding aryl aldehydes and the acid hydrazide 2.
N. Rezki, M. Aouad, R. Al-Bayati, A. Sharba   +3 more
doaj   +1 more source

Inductive queries for a drug designing robot scientist [PDF]

, 2010
It is increasingly clear that machine learning algorithms need to be integrated in an iterative scientific discovery loop, in which data is queried repeatedly by means of inductive queries and where the computer provides guidance to the experiments that ...
A. Lingas, C. Hansch, C.A. Lipinski, D.R. Jones, D.R. Jones, H. Blockeel, J. Matousek, L. Raedt De, R.D. King, R.D. King, T. Gärtner   +10 more
core   +1 more source