Results 31 to 40 of about 27,190 (294)

Synthesis and liquid crystalline studies of biphenylyl-1,3,4-thiadiazoles and diphenyl-1,3,4-thiadiazoles: influence of side chain semifluorination and lateral ring fluorination

Liquid crystals (Print), 2021
Four series of 1,3,4-thiadiazole based compounds (Series I–IV) were synthesised, and their liquid crystalline properties were studied. Series I compounds are two tailed biphenylyl-1,3,4-thiadiazoles (seven new compounds).
F. Fouad, M. Khairuddean, R. Twieg
semanticscholar   +1 more source

Synthesis, Molecular Docking Screening and Anti-Proliferative Potency Evaluation of Some New Imidazo[2,1-b]Thiazole Linked Thiadiazole Conjugates

Molecules, 2020
Background: Imidazo[2,1-b]thiazole scaffolds were reported to possess various pharmaceutical activities. Results: The novel compound named methyl-2-(1-(3-methyl-6-(p-tolyl)imidazo[2,1-b]thiazol-2-yl)ethylidene)hydrazine-1-carbodithioate 3 acted as a ...
Huda R. M. Rashdan, Aboubakr H. Abdelmonsef, Ihsan A. Shehadi, Sobhi M. Gomha, Abdel Mohsen M. Soliman, Huda K. Mahmoud   +5 more
doaj   +1 more source

On the Development of Selective Chelators for Cadmium: Synthesis, Structure and Chelating Properties of 3-((5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl)amino)benzo[d]isothiazole 1,1-dioxide, a Novel Thiadiazolyl Saccharinate

Molecules, 2021
Aquatic contamination by heavy metals is a major concern for the serious negative consequences it has for plants, animals, and humans. Among the most toxic metals, Cd(II) stands out since selective and truly efficient methodologies for its removal are ...
Joana F. Leal, Bruno Guerreiro, Patrícia S. M. Amado, André L. Fernandes, Luísa Barreira, José A. Paixão, Maria L. S. Cristiano   +6 more
doaj   +1 more source

A Novel Approach to the Synthesis of 1,3,4-Thiadiazole-2-amine Derivatives

Molecules, 2021
The main purpose of the study was the development of a new method for synthesis of 1,3,4-thiadiazol-2-amine derivatives in a one-pot manner using the reaction between a thiosemicarbazide and carboxylic acid without toxic additives such as POCl3 or SOCl2.
Tatiana S. Kokovina, Svyatoslav Y. Gadomsky, Alexei A. Terentiev, Nataliya A. Sanina   +3 more
doaj   +1 more source

Synthesis and Preliminary Anticancer Activity Assessment of N-Glycosides of 2-Amino-1,3,4-thiadiazoles

Molecules, 2021
The addition of 2-amino-1,3,4-thiadiazole derivatives with parallel iodination of differently protected glycals has been achieved using a double molar excess of molecular iodine under mild conditions.
Katarzyna Żurawska, Marcin Stokowy, Patryk Kapica, Monika Olesiejuk, A. Kudelko, K. Papaj, M. Skonieczna, W. Szeja, K. Walczak, A. Kasprzycka   +9 more
semanticscholar   +1 more source

Design and Synthesis of New Benzo[d]oxazole-Based Derivatives and Their Neuroprotective Effects on β-Amyloid-Induced PC12 Cells

Molecules, 2020
A series of novel synthetic substituted benzo[d]oxazole-based derivatives (5a–5v) exerted neuroprotective effects on β-amyloid (Aβ)-induced PC12 cells as a potential approach for the treatment of Alzheimer’s disease (AD).
Zheng Liu, Ming Bian, Qian-Qian Ma, Zhuo Zhang, Huan-Huan Du, Cheng-Xi Wei   +5 more
doaj   +1 more source

Synthesis, Characterization, and In Vivo Study of Some Novel 3,4,5-Trimethoxybenzylidene-hydrazinecarbothioamides and Thiadiazoles as Anti-Apoptotic Caspase-3 Inhibitors

Molecules, 2022
The present study aims to discover novel derivatives as antiapoptotic agents and their protective effects against renal ischemia/reperfusion. Therefore, a series of new thiadiazole analogues 2a–g was designed and synthesized through cyclization of the ...
Sara M. Mostafa, Ashraf A. Aly, Stefan Bräse, Martin Nieger, Sara Mohamed Naguib Abdelhafez, Walaa Yehia Abdelzaher, El-Shimaa M. N. Abdelhafez   +6 more
doaj   +1 more source

3-Phenoxymethyl-6-phenyl-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole

IUCrData, 2016
In the title compound, C16H12N4OS, the bicyclic triazolothiadiazole core is approximately planar, with an r.m.s. deviation of 0.018 Å. The phenyl rings are inclined to its mean plane by 7.66 (7) and 71.79 (7)°.
Shaaban K. Mohamed, Joel T. Mague, Mehmet Akkurt, Etify A. Bakhite, Mustafa R. Albayati   +4 more
doaj   +1 more source

Crystal structure of 6-(2-fluorophenyl)-3-phenyl-[1,2,4]-triazolo[3,4-b][1,3,4]thiadiazole, C15H9FN4S [PDF]

, 2016
C15H9FN4S, orthorhombic, Pna21 (no. 33), a = 18.9361(2) Å, b = 11.5248(1) Å, c = 6.0142(1) Å, V = 1312.52(3) Å3, Z = 4, R gt (F) = 0.0263, wR ref (F 2
Al-Alshaikh, M. A., El-Emam, A. Ali, García-Granda, Santiago, Ghabbour, H. A., Said Mohammed Abdelbaky, Mohammed   +4 more
core   +1 more source

I2/DMSO-Catalyzed Transformation of N-tosylhydrazones to 1,2,3-thiadiazoles

Frontiers in Chemistry, 2020
An iodine/DMSO catalyzed selective cyclization of N-tosylhydrazones with sulfur without adding external oxidant was developed for the synthesis of 4-aryl-1,2,3-thiadiazoles.
Weiwei Li, Jun Zhang, Jing-Dong He, Liang Xu, L. Vaccaro, Ping Liu, Yanlong Gu   +6 more
semanticscholar   +1 more source