Results 41 to 50 of about 27,190 (294)

Direct Exchange of Oxygen and Selenium Atoms in the 1,2,5-Oxadiazoles and 1,2,5-Selenadiazoles by Action of Sulfur Monochloride

Molecules, 2015
A short synthetic approach to fused 1,2,5-thiadiazoles from the corresponding 1,2,5-oxadiazoles and 1,2,5-selenadiazoles has been developed. Mono- and bis(1,2,5-thiadiazoles) were selectively obtained in high yields.
Lidia S. Konstantinova, Ekaterina A. Knyazeva, Oleg A. Rakitin   +2 more
doaj   +1 more source

Antiviral activity of thiadiazoles, oxadiazoles, triazoles and thiazoles

ARKIVOC, 2020
Drugs containing the heterocyclic five-membered thiadiazoles and isosteres possess a wide range of biological activities, including but not limited to, antiviral, antifungal, antihistamine, anticancer.
Samar S. Tawfik, Mengyao Liu, Abdelbasset A. Farahat   +2 more
semanticscholar   +1 more source

Acute toxicity of 3-(2-, 3-fluorophenyl)-6-(aryl-, hetaryl)-[1,2,4]triazole[3,4-b][1,3,4]thiadiazoles

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2017
Nowadays an attempt to create a number of new biologically active compounds by many scientific groups is being one of the topical issues in the domestic pharmaceutical industry.
O. A. Bihdan, V. V. Parchenko
doaj   +1 more source

Synthesis of Novel Triazoles, Tetrazine, Thiadiazoles and Their Biological Activities

Molecules, 2015
An expedient synthesis of novel triazoles, tetrazine and thiadiazoles, using conveniently accessible and commercially available starting materials has been achieved.
Mohammed A. Al-Omair, Abdelwahed R. Sayed, Magdy M. Youssef   +2 more
doaj   +1 more source

Antioxidant and prooxidant activity of new 1,2-diols and thiadiazoles derivatives in Saccharomyces cerevisiae yeast cells

Cumhuriyet Science Journal, 2020
The present research was undertaken to determine the effect of substituted 2,2'-[(2R,3R)-2,3-dihydroxy-1,4-dioxobutane-1,4-diyl]bis(N-R-hydrazine-1-carbothioamide and (1R,2R)-1,2-bis[5-(R-amino)-1,3,4-thiadiazole-2-yl]ethane-1,2-diols on the antioxidant ...
Ahmet Çetin, Arzu Karatepe
doaj   +1 more source

Palladium-Catalyzed Direct (Het)arylation Reactions of Benzo[1,2-d:4,5-d′]bis([1,2,3]thiadiazole and 4,8-Dibromobenzo[1,2-d:4,5-d′]bis([1,2,3]thiadiazole)

Molecules, 2023
Palladium-catalyzed direct (het)arylation reactions of strongly electron-withdrawing tricyclic benzo[1,2-d:4,5-d′]bis([1,2,3]thiadiazole) and its 4,8-dibromo derivative were studied; the conditions for the selective formation of mono- and bis-aryl ...
Timofey N. Chmovzh, Timofey A. Kudryashev, Daria A. Alekhina, Oleg A. Rakitin   +3 more
doaj   +1 more source

A convenient synthesis of 1,3,4-thiadiazole and 1,3,4-oxadiazole based peptidomimetics employing diacylhydrazines derived from amino acids [PDF]

, 2010
Synthesis of novel orthogonally protected 1,3,4-thiadiazole and 1,3,4-oxadiazole tethered dipeptide mimetics is described. Both the heterocycles are prepared via a set of diacylhydrazines derived from amino acids.
Lamani, R.S., Nagendra, G., Narendra, N., Sureshbabu, V.V.   +3 more
core   +1 more source

Polyterthiophenes incorporating 3,4-difluorothiophene units : application in organic field-effect transistors [PDF]

, 2010
Two terthiophenes bearing core fluorinated thienyl units have been synthesised as potential semiconductor materials for organic field-effect transistors.
Crouch, David J., Heeney, Martin, McCulloch, Iain, Skabara, Peter, Sparrowe, David   +4 more
core   +1 more source

Targeting the Membrane‐Embedded Rhomboid Protease GlpG: A Multimodal Strategy for Inhibitor Discovery and Mechanistic Insight

Angewandte Chemie, EarlyView.
Created in BioRender. Bohg, C. (2026) https://BioRender.Com/ vi9hi4f. Rhomboid proteases are a mechanistically unique and evolutionarily conserved protein family. Despite their pharmacological relevance, the development of selective inhibitors has lagged behind that of soluble proteases.
Claudia Bohg, Yurii Dubanych, Spyridon Kosteletos, Taoran Xiao, Martin Neuenschwander, Tillmann Utesch, Michael Lisurek, Carl Öster, Andreas Oder, Carola Seyffarth, Kathrin Bach, Denise‐Liù Gracias Leone, František Filandr, Marc Wegert, Sascha Lange, Henry Sawczyc, Jens Peter von Kries, Christian P. R. Hackenberger, Edgar Specker, Han Sun, Kvido Stříšovský, Adam Lange   +21 more
wiley   +2 more sources

Biological activities of imidazo[2,1-b][1,3,4]thiadiazole derivatives: A review

Journal of Saudi Chemical Society, 2016
Imidazo[2,1-b][1,3,4]thiadiazole heterocycle was discovered during the 1950s. Since then, many newer derivatives are being developed and evaluated for their biological profiles. The derivatives of imidazo[2,1-b][1,3,4]thiadiazoles are widely explored for
Bhoomendra A. Bhongade, Sirajunisa Talath, Ravikiran A. Gadad, Andanappa K. Gadad   +3 more
doaj   +1 more source