Results 131 to 140 of about 67,735 (340)

New Pyridobenothiazolone Derivatives Display Nanomolar Pan‐Serotype Anti‐Dengue Virus Activity

ChemMedChem, EarlyView.
A ligand‐based strategy is employed, starting from hit compound 2, to develop the C‐2 modified pyridobenzothiazolone 19 as a pan‐serotype nanomolar DENV‐1‐4 inhibitor. Investigations of the mechanism reveal the peculiar ability to abolish the infectivity of virions in a second infection.
Tommaso Felicetti, Chin Piaw Gwee, Kitti Wing Ki Chan, Giacomo Pepe, Ciro Milite, Pietro Campiglia, Satoru Watanabe, Muhammad Danial Bin Mohd Mazlan, Stefano Sabatini, Serena Massari, Oriana Tabarrini, Gianluca Sbardella, Subhash G. Vasudevan, Giuseppe Manfroni   +13 more
wiley   +1 more source

5-[(4-Bromophenyl)diazenyl]-2-{2-[1-(1H-indol-3-yl)ethylidene]hydrazinyl}-4-methylthiazole dimethylformamide hemisolvate

IUCrData, 2018
The asymmetric unit of the title compound, 2C20H17BrN6S·C3H7NO, comprises two molecules of the thiazole derivative and one molecule of dimethylformamide (DMF) solvent.
Gamal A. El-Hiti, Bakr F. Abdel-Wahab, Mohammad Hayal Alotaibi, Emad Yousif, Amany S. Hegazy, Benson M. Kariuki   +5 more
doaj   +1 more source

Development of Carborane‐Based Halogenated Naphthyridinone‐Analoga as Cannabinoid Receptor Type 2 (CB2R) Ligands

ChemMedChem, Accepted Article.
The cannabinoid receptor type 2 (CB2R) is overexpressed under pathological conditions. PET is a suitable non‐invasive imaging technique for diagnosing disease states, but requires a radiotracer that binds to CB2R with high affinity and selectivity. Currently, there is no suitable candidate routinely used in the clinics.
Lea Ueberham, Winnie Deuther-Conrad, Peter Lönnecke, Aleksandr Kazimir, Evamarie Hey-Hawkins   +4 more
wiley   +1 more source

Synthesis, Biological Evaluation, and Molecular Docking Studies of Novel Isatin-Thiazole Derivatives as α-Glucosidase Inhibitors

Molecules, 2017
A series of novel isatin-thiazole derivatives were synthesized and screened for their in vitro α-glucosidase inhibitory activity. These compounds displayed a varying degree of α-glucosidase inhibitory activity with IC50 ranging from 5.36 ± 0.13 to 35.76 ±
Zhenzhen Xie, Guangcheng Wang, Jing Wang, Ming Chen, Yaping Peng, Luyao Li, Bing Deng, Shan Chen, Wenbiao Li   +8 more
doaj   +1 more source

Low‐Micromolar Quantification of Fluorinated Analytes Using Hyperpolarized 19F Benchtop Nuclear Magnetic Resonance

Chemistry–Methods, EarlyView.
Limits of detection and quantification of fluorinated analytes by 19F benchtop (1 T) NMR spectroscopy in the high nanomolar to low micromolar range are achieved using signal amplification by reversible exchange (SABRE) combined with the multiplet‐refocusing technique, SHARPER (Sensitive, Homogeneous, And Resolved PEaks in Real time).
Ana I. Silva Terra, Meghan E. Halse
wiley   +1 more source

Infrared Dielectric Function of Photochromic Thiazolothiazole Embedded Polymer [PDF]

arXiv
In this paper, the infrared dielectric function of photochromic dipyridinium thiazolo[5,4-d]thiazole embedded in polymer is reported. Bulk thiazolo[5,4-d]thiazole-embedded polymer samples were prepared by drop casting and dehydration in room temperature.
arxiv  

Influence of Thiazole-modified Carbon Nitride Nanosheets with Feasible Electronic Properties on Inverted Perovskite Solar Cells.

Journal of the American Chemical Society, 2019
Effective, solution processable designs of interfacial electron transporting layers (ETLs) or hole-blocking layers are promising tools in modern electronic devices, e.g. to improve performance, cost and stability of perovskite-based solar cells.
D. Cruz, José Garcia Cerrillo, B. Kumru, Ning Li, J. Darío Perea, B. V. Schmidt, I. Lauermann, C. Brabec, M. Antonietti   +8 more
semanticscholar   +1 more source

Expanding the Horizons of Phototherapy: A Review on the Superior Performance of Chalcogen‐Based Photosensitizers and Photothermal Agents for Cancer Therapy

ChemPhotoChem, EarlyView.
This review summarizes recent progress in chalcogen (S, Se, Te)‐incorporated photosensitizers and photothermal agent design. It explores synthetic strategies, spectroscopic and computational characterization, and in vitro/in vivo evaluations, showcasing the potential of these compounds for photodynamic and photothermal therapies.
Subhrakant Jena, Pranay Mohanty, Laxmipriya Dash, Himansu S. Biswal   +3 more
wiley   +1 more source

Crystal structure of ethyl 5-(3-fluorophenyl)-2-[(4-fluorophenyl)methylidene]-7-methyl-3-oxo-2H,3H,5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate

Acta Crystallographica Section E, 2014
In the title molecule, C23H18F2N2O3S, the pyrimidine ring is in a half-chair conformation and the 3-fluorophenyl group is in the axial position. The thiazole ring (r.m.s.
M. S. Krishnamurthy, H. Nagarajaiah, Noor Shahina Begum   +2 more
doaj   +1 more source

Multicomponent Assembly of Proposed DNA Precursors in Water [PDF]

, 2012
We propose a novel pathway for the prebiotic synthesis of 2′-deoxynucleotides. Consideration of the constitutional chemical relationships between glycolaldehyde and β-mercapto-acetaldehyde, and the corresponding proteinogenic amino acids, serine and ...
Powner, Matthew W., Szostak, Jack William, Zheng, Shao-Liang   +2 more
core   +1 more source