Results 11 to 20 of about 59,616 (308)

Synthesis, modeling, and biological studies of new thiazole-pyrazole analogues as anticancer agents

Journal of Saudi Chemical Society, 2023
A series of various substituted thiazole-pyrazole hybrids 5, 7, 8, and 9 were synthesized, and their chemical structures were confirmed by spectral data (infrared, 1H & 13C NMR and Mass).
Gadeer R.S. Ashour, Ahmad Fawzi Qarah, Abdulmajeed F. Alrefaei, Adel I. Alalawy, Amerah Alsoliemy, Alaa M. Alqahtani, Wael M. Alamoudi, Nashwa M. El-Metwaly   +7 more
doaj   +1 more source

Methyl 2-(4-ferrocenylbenzamido)thiophene-3-carboxylate and ethyl 2-(4-ferrocenylbenzamido)-1,3-thiazole-4-acetate, a unique ferrocen [PDF]

, 2005
The conformations and hydrogen bonding in the thiophene and thiazole title compounds, [Fe(C₅H₅)(C₂₀H₁₄NO₃S)], (I), and [Fe(C₅H₅)(C₁₉H₁₇N₂O₃S)], (II), are discussed.
Alley, Steven, Gallagher, John F., Hooper, Vincent M., Kenny, Peter T.M., Lough, Alan J.   +4 more
core   +1 more source

Indolinyl-Thiazole Based Inhibitors of Scavenger Receptor-BI (SR-BI)-Mediated Lipid Transport [PDF]

, 2014
A potent class of indolinyl-thiazole based inhibitors of cellular lipid uptake mediated by scavenger receptor, class B, type I (SR-BI) was identified via a high-throughput screen of the National Institutes of Health Molecular Libraries Small Molecule ...
Bennion, Melissa, Dandapani, Sivaraman, Dockendorff, Chris, Faloon, Patrick W., Krieger, Monty, Lam, Garrett, Lewis, Timothy A., Munoz, Benito, Nag, Partha P., Negri, Joseph, Nieland, Thomas J.F., Palmer, Michelle A., Paterson, Conor, Penman, Marsha, Perez, José R., Pu, Jun, Schreiber, Stuart L., Youngsaye, Willmen, Yu, Miao   +18 more
core   +3 more sources

Stereoselective synthesis, X-ray analysis, computational studies and biological evaluation of new thiazole derivatives as potential anticancer agents

Chemistry Central Journal, 2018
Background The synthesis of new thiazole derivatives is very important because of their diverse biological activities. Also , many drugs containing thiazole ring in their skeletons are available in the market such as Abafungin, Acotiamide, Alagebrium ...
Yahia N. Mabkhot, Mohammed M. Alharbi, Salim S. Al-Showiman, Hazem A. Ghabbour, Nabila A. Kheder, Saied M. Soliman, Wolfgang Frey   +6 more
doaj   +1 more source

Fluorescent turn-on probes for wash-free mRNA imaging via covalent site-specific enzymatic labeling. [PDF]

, 2017
Investigating the many roles RNA plays in cellular regulation and function has increased demand for tools to explore RNA tracking and localization within cells.
Alexander, Seth C, Devaraj, Neal K, Zhou, Cun Yu   +2 more
core   +2 more sources

Activity of antioxidant enzymes in hepatocytes of mice with lymphoma under the action of thiazole derivative in complex with polymeric nanocarrier

Біологія тварин, 2023
Many chemotherapeutics drugs have low water solubility, which potentially can decrease their anticancer potential. The use of drug delivery systems has proven to be highly effective in addressing the challenges associated with delivering hydrophobic ...
B. Omeliukh, Ya. Shalai, M. Bura, M. Ilkiv, Yu. Ostapiuk, N. Mitina, O. Zaichenko, A. Babsky   +7 more
doaj   +1 more source

Toward eradication of B-vitamin deficiencies : considerations for crop biofortification [PDF]

, 2018
'Hidden hunger' involves insufficient intake of micronutrients and is estimated to affect over two billion people on a global scale. Malnutrition of vitamins and minerals is known to cause an alarming number of casualties, even in the developed world ...
Strobbe, Simon, Van Der Straeten, Dominique   +1 more
core   +3 more sources

Synthesis and biological activity evaluation of new functionally substituted 5-arylidene-2,4-dioxotetrahydro-1,3-thiazoles [PDF]

Journal of the Serbian Chemical Society, 2006
New functionally substituted 5-arylidene-2,4-dioxotetrahydro-1,3-thiazole-3-carboxylic acid cholesteryl esters were synthesized from 2,4-dioxotetrahydro-1,3-thiazole and evaluated for their in vitro cytotoxicity against several human tumor cell lines and
MIROSLAV PERGAL, MILICA RANCIC, KATARINA POPOV-PERGAL, GORDANA BOGDANOVIC, VESNA KOJIC, DEJAN DJOKOVIC   +5 more
doaj   +3 more sources

Synthesis of camphor thiazole derivates from Dryobalanops aromatica and its bioactivity as antioxidants and antidiabetes against alpha glucosidase enzymes

MethodsX, 2023
Camphor is synthesized from the Sumatran camphor plant (Dryobalanops aromatica) in previous experiments. It can be synthesized with thiosemicarbazide, ethy-2‑chloro acetoacetate, and sodium acetate (catalyze) to form camphor derivate with thiazole ring ...
Antonius Herry Cahyana, Gusman Santika, Kandarpa Phukan   +2 more
doaj   +1 more source

Synthesis, molecular modeling and bioactivity of new bis-thiazole, thiazole-pyrazole, and thiazole-pyridine analogues

Journal of Saudi Chemical Society, 2023
Several new thiazole derivatives linked pyrazole and/or pyridine rings were synthesized based on the versatile precursor 2-(5-acetyl-4-methyl-3-phenylthiazol-2(3H)-ylidene)acetonitrile (1). The synthesized derivatives were optimized using DFT approach in order to inspect the configurations and energies of the HOMO-LUMO orbitals.
Abrar Bayazeed, Rua B. Alnoman, Kahdr Alatawi, Omar M. Alatawi, Alaa M. Alqahtani, Mariam Mojally, Noof A. Alenazi, Nashwa M. El-Metwaly   +7 more
openaire   +2 more sources