Results 11 to 20 of about 24,222 (188)

Stereoselective synthesis, X-ray analysis, computational studies and biological evaluation of new thiazole derivatives as potential anticancer agents

Chemistry Central Journal, 2018
Background The synthesis of new thiazole derivatives is very important because of their diverse biological activities. Also , many drugs containing thiazole ring in their skeletons are available in the market such as Abafungin, Acotiamide, Alagebrium ...
Yahia N. Mabkhot, Mohammed M. Alharbi, Salim S. Al-Showiman, Hazem A. Ghabbour, Nabila A. Kheder, Saied M. Soliman, Wolfgang Frey   +6 more
doaj   +1 more source

Activity of antioxidant enzymes in hepatocytes of mice with lymphoma under the action of thiazole derivative in complex with polymeric nanocarrier

Біологія тварин, 2023
Many chemotherapeutics drugs have low water solubility, which potentially can decrease their anticancer potential. The use of drug delivery systems has proven to be highly effective in addressing the challenges associated with delivering hydrophobic ...
B. Omeliukh, Ya. Shalai, M. Bura, M. Ilkiv, Yu. Ostapiuk, N. Mitina, O. Zaichenko, A. Babsky   +7 more
doaj   +1 more source

Synthesis, molecular modeling and bioactivity of new bis-thiazole, thiazole-pyrazole, and thiazole-pyridine analogues

Journal of Saudi Chemical Society, 2023
Several new thiazole derivatives linked pyrazole and/or pyridine rings were synthesized based on the versatile precursor 2-(5-acetyl-4-methyl-3-phenylthiazol-2(3H)-ylidene)acetonitrile (1). The synthesized derivatives were optimized using DFT approach in order to inspect the configurations and energies of the HOMO-LUMO orbitals.
Abrar Bayazeed, Rua B. Alnoman, Kahdr Alatawi, Omar M. Alatawi, Alaa M. Alqahtani, Mariam Mojally, Noof A. Alenazi, Nashwa M. El-Metwaly   +7 more
openaire   +2 more sources

Synthesis of camphor thiazole derivates from Dryobalanops aromatica and its bioactivity as antioxidants and antidiabetes against alpha glucosidase enzymes

MethodsX, 2023
Camphor is synthesized from the Sumatran camphor plant (Dryobalanops aromatica) in previous experiments. It can be synthesized with thiosemicarbazide, ethy-2‑chloro acetoacetate, and sodium acetate (catalyze) to form camphor derivate with thiazole ring ...
Antonius Herry Cahyana, Gusman Santika, Kandarpa Phukan   +2 more
doaj   +1 more source

Demethylation and desulfonation of textile industry dye, Thiazole Yellow G by Aspergillus niger LAG

Biotechnology Reports, 2019
Filamentous fungi perform tremendously in adsorption of dyes from polluted environment. In this study, Aspergillus niger LAG decolorized thiazole yellow G dye within 5 days. Scale up studies done revealed that maximum decolorization (98%) was achieved at
Paul O. Bankole, Adedotun A. Adekunle, Sanjay P. Govindwar   +2 more
doaj   +1 more source

Molecular modeling and docking of new 2-acetamidothiazole-based compounds as antioxidant agents

Journal of Saudi Chemical Society, 2022
The highly versatile, 2-chloroacetamido-5-(4-chlorophenylazo)thiazole (2) was synthesized and used as a precursor for the production of five 2-(2-substitutedacetamido)thiazole compounds by its reaction with different types of nucleophiles such as ...
Sraa Abu-Melha
doaj   +1 more source

Thiazole, triazole, thio- and semicarbazone derivatives - Promising moieties for drug development for the treatment of tuberculosis

European Journal of Medicinal Chemistry Reports, 2021
Thiazole, triazole, thio and semicarbazones are privileged motifs that act as pharmacophores in bioactive compounds for various diseases, such as Tuberculosis (TB).
Cauê Benito Scarim, Fernando Rogério Pavan   +1 more
doaj   +1 more source

An Organometallic [2]Catenane With Pt‒(di‐NHC)‒Pt Units: A Topology‐Driven Strategy for Enhanced Phosphorescence in Discrete Aggregates

Angewandte Chemie, EarlyView.
The mechanically interlocked Borromean rings are stabilized by π···π stacking interactions while the [2]catenane is stabilized by solvophobic effects. While the π···π interactions in the Borromean rings lead to severe luminescence quenching, the solvophobically assembled [2]catenane effectively circumvents these interactions, simultaneously restricting
Ye Lu, Xi‐Dong Wu, Zi‐Yan Min, Lu An, Shi‐Ping Yang, F. Ekkehardt Hahn   +5 more
wiley   +2 more sources

Photocatalytic Cross‐Coupling of Phenols and Heteroaryl Halides With Machine Learning‐Guided Reaction Prediction

Angewandte Chemie, EarlyView.
Photocatalytic cross‐coupling: A redox‐neutral photochemical method enables direct C(sp2)─C(sp2) bond formation between phenols and heteroaryl halides using an organic dye and base. Complementary radical generation allows efficient cross‐coupling in up to 91% yield. Mechanistic studies, DFT, HTE, and machine learning rationalize and predict reactivity,
Matthew C. Carson, Alice Wu, Kalyana B. Duggal, Madeline E. Rotella, Marisa C. Kozlowski   +4 more
wiley   +2 more sources

2-(Benzothiazol-2-ylsulfanyl)acetic acid

Acta Crystallographica Section E, 2010
In the title compound, C9H7NO2S2, the benzine ring is essentially co-planar with the thiazole ring, making a dihedral angle of 0.36 (7)°. In the crystal structure, molecules are linked by intermolecular O—H...N hydrogen bonds
Zhi-li Fang, Jun Wang
doaj   +1 more source