Results 11 to 20 of about 424,053 (243)

Thick filament mechano-sensing is a calcium-independent regulatory mechanism in skeletal muscle [PDF]

Nature Communications, 2016
Recent data suggest that muscle contraction is regulated by thick filament mechano-sensing in addition to the well-known thin filament-mediated calcium signalling pathway. Here the authors provide direct evidence that myosin activation in skeletal muscle
L. Fusi, E. Brunello, Z. Yan, M. Irving
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The giant protein titin regulates the length of the striated muscle thick filament

Nature Communications, 2017
Thick filaments in skeletal muscle and heart are composed of myosin. The authors show that the length of thick filaments is defined by titin, and that alterations in titin length affect force generation and lead to dilated cardiomyopathy in mice.
Paola Tonino, Balazs Kiss, Josh Strom, Mei Methawasin, John E. Smith, Justin Kolb, Siegfried Labeit, Henk Granzier   +7 more
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Dependence of thick filament structure in relaxed mammalian skeletal muscle on temperature and interfilament spacing [PDF]

, 2021
International audienceContraction of skeletal muscle is regulated by structural changes in both actin-containing thin filaments and myosin-containing thick filaments, but myosin-based regulation is unlikely to be preserved after thick filament isolation,
Gabriella Piazzesi, Caremani, Marco, Elisabetta Brunello, Reconditi, Massimo, Linari, Marco, Thomas C. Irving, Brunello, Elisabetta; id_orcid, Lombardi, V., Reconditi, M., Luca Fusi, Narayanan, Theyencheri, Massimo Reconditi, Brunello, E., Marco Linari, Irving, Malcolm, Fusi, Luca, Theyencheri Narayanan, Irving, Thomas C., Piazzesi, G., Caremani, M., Vincenzo Lombardi, Marco Caremani, Lombardi, Vincenzo, Brunello, Elisabetta, Malcolm Irving, Linari, M., Piazzesi, Gabriella   +26 more
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THICK FILAMENTS IN VASCULAR SMOOTH MUSCLE [PDF]

The Journal of Cell Biology, 1971
Two sets of myofilaments were demonstrated after incubation of strips of rabbit portal-anterior mesenteric vein under moderate stretch in a physiological salt solution. Thick filaments had a mean diameter of 18 nm and reached a maximum length of 1.4 µm with a mean length of 0.61 µm.
C E, Devine, A P, Somlyo
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Differences in cell wall of thin and thick filaments of cyanobacterium Aphanizomenon gracile SAG 31.79 and their implications for different resistance to Daphnia grazing

Journal of Limnology, 2016
Recent studies have shown that the filamentous cyanobacterium Aphanizomenon gracile Lemmermann, strain SAG 31.79, consists of two types of filaments that differ in thickness.
Lukasz Wejnerowski, Slawek Cerbin, Maria K. Wojciechowicz, Marcin K. Dziuba   +3 more
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Thick filament movement and isometric tension in activated skeletal muscle [PDF]

, 1988
Thick filaments can move from the center of the sarcomere to the Z-disc while the isometric tension remains stable in skinned rabbit psoas fibers activated for several minutes (Horowits and Podolsky, 1987).
Horowits, R., Podolsky, R.J.
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Cycling Cross-Bridges Contribute to Thin Filament Activation in Human Slow-Twitch Fibers

Frontiers in Physiology, 2020
It has been shown that not only calcium but also strong binding myosin heads contribute to thin filament activation in isometrically contracting animal fast-twitch and cardiac muscle preparations. This behavior has not been studied in human muscle fibers
Alfredo Jesus López-Dávila, Joseph M. Chalovich, Stefan Zittrich, Birgit Piep, Faramarz Matinmehr, Andras Málnási-Csizmadia, Anna Á. Rauscher, Theresia Kraft, Bernhard Brenner, Robert Stehle   +9 more
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Myosin: Formation and maintenance of thick filaments [PDF]

Animal Science Journal, 2019
AbstractSkeletal muscle consists of bundles of myofibers containing millions of myofibrils, each of which is formed of longitudinally aligned sarcomere structures. Sarcomeres are the minimum contractile unit, which mainly consists of four components: Z‐bands, thin filaments, thick filaments, and connectin/titin.
openaire   +2 more sources

Structure of the hDmc1-ssDNA filament reveals the principles of its architecture [PDF]

, 2010
In eukaryotes, meiotic recombination is a major source of genetic diversity, but its defects in humans lead to abnormalities such as Down's, Klinefelter's and other syndromes.
Dmitry V Bugreev, Julie Hodgkinson, Yuriy L Chaban, Bugreev, DV, Orlova, Elena, Orlova, EV, Hodgkinson, J.L., Orlova Elena V., Chaban, Y.L., Bugreev, D.V., Andrei L Okorokov, Chaban Yuriy L., Okorokov, AL, Elena V Orlova, Okorokov, A.L., Hodgkinson, J, Bugreev Dmitry V., Chaban, YL, Okorokov Andrei L., Mazin, AV, Hodgkinson Julie, Mazin, A.V., Alexander V Mazin, Mazin Alexander V.   +23 more
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F-actin architecture determines constraints on myosin thick filament motion

Nature Communications, 2022
While the impact of F-actin architecture on stress transmission is well studied, the role of architecture on stress generation remains unclear. Here authors use in vitro model and show that distinct organizations constrain myosin motion.
Camelia G. Muresan, Zachary Gao Sun, Vikrant Yadav, A. Pasha Tabatabai, Laura Lanier, June Hyung Kim, Taeyoon Kim, Michael P. Murrell   +7 more
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