The giant protein titin regulates the length of the striated muscle thick filament [PDF]
Nature Communications, 2017 Thick filaments in skeletal muscle and heart are composed of myosin. The authors show that the length of thick filaments is defined by titin, and that alterations in titin length affect force generation and lead to dilated cardiomyopathy in mice.
Paola Tonino +7 more
doaj +3 more sources
Thick Filament Protein Network, Functions, and Disease Association. [PDF]
Compr Physiol, 2018 ABSTRACTSarcomeres consist of highly ordered arrays of thick myosin and thin actin filaments along with accessory proteins. Thick filaments occupy the center of sarcomeres where they partially overlap with thin filaments. The sliding of thick filaments past thin filaments is a highly regulated process that occurs in an ATP‐dependent manner driving ...
Wang L +4 more
europepmc +3 more sources
Muscle Mechanics and Thick Filament Activation: An Emerging Two-Way Interaction for the Vertebrate Striated Muscle Fine Regulation. [PDF]
Int J Mol Sci, 2023 Marcucci L.
europepmc +2 more sources
Thin filament cardiomyopathies: A review of genetics, disease mechanisms, and emerging therapeutics
Frontiers in Cardiovascular Medicine, 2022 All muscle contraction occurs due to the cyclical interaction between sarcomeric thin and thick filament proteins within the myocyte. The thin filament consists of the proteins actin, tropomyosin, Troponin C, Troponin I, and Troponin T.
Lucas K. Keyt +7 more
doaj +1 more source
Sarcomere lattice geometry influences cooperative myosin binding in muscle. [PDF]
PLoS Computational Biology, 2007 In muscle, force emerges from myosin binding with actin (forming a cross-bridge). This actomyosin binding depends upon myofilament geometry, kinetics of thin-filament Ca(2+) activation, and kinetics of cross-bridge cycling.
Bertrand C W Tanner +2 more
doaj +1 more source
Myosin-based regulation of twitch and tetanic contractions in mammalian skeletal muscle
eLife, 2021 Time-resolved X-ray diffraction of isolated fast-twitch muscles of mice was used to show how structural changes in the myosin-containing thick filaments contribute to the regulation of muscle contraction, extending the previous focus on regulation by the
Cameron Hill +4 more
doaj +1 more source
THICK FILAMENTS IN VASCULAR SMOOTH MUSCLE [PDF]
The Journal of Cell Biology, 1971 Two sets of myofilaments were demonstrated after incubation of strips of rabbit portal-anterior mesenteric vein under moderate stretch in a physiological salt solution. Thick filaments had a mean diameter of 18 nm and reached a maximum length of 1.4 µm with a mean length of 0.61 µm.
C E, Devine, A P, Somlyo
openaire +2 more sources
Head-head interactions of resting myosin crossbridges in intact frog skeletal muscles, revealed by synchrotron x-ray fiber diffraction. [PDF]
PLoS ONE, 2012 The intensities of the myosin-based layer lines in the x-ray diffraction patterns from live resting frog skeletal muscles with full thick-thin filament overlap from which partial lattice sampling effects had been removed were analyzed to elucidate the ...
Kanji Oshima +3 more
doaj +1 more source
Force Measurements From Myofibril to Filament
Frontiers in Physiology, 2022 Contractility, the generation of force and movement by molecular motors, is the hallmark of all muscles, including striated muscle. Contractility can be studied at every level of organization from a whole animal to single molecules.
Steven Marston
doaj +1 more source