The giant protein titin regulates the length of the striated muscle thick filament [PDF]
Nature Communications, 2017 Thick filaments in skeletal muscle and heart are composed of myosin. The authors show that the length of thick filaments is defined by titin, and that alterations in titin length affect force generation and lead to dilated cardiomyopathy in mice.
Paola Tonino +7 more
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Muscle Mechanics and Thick Filament Activation: An Emerging Two-Way Interaction for the Vertebrate Striated Muscle Fine Regulation [PDF]
International Journal of Molecular Sciences, 2023 Lorenzo Marcucci, Marcucci Lorenzo
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Differences in thick filament activation in fast rodent skeletal muscle and slow porcine cardiac muscle [PDF]
Journal of PhysiologyThomas C Irving, Weikang Ma
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Thin filament cardiomyopathies: A review of genetics, disease mechanisms, and emerging therapeutics
Frontiers in Cardiovascular Medicine, 2022 All muscle contraction occurs due to the cyclical interaction between sarcomeric thin and thick filament proteins within the myocyte. The thin filament consists of the proteins actin, tropomyosin, Troponin C, Troponin I, and Troponin T.
Lucas K. Keyt +7 more
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Sarcomere lattice geometry influences cooperative myosin binding in muscle. [PDF]
PLoS Computational Biology, 2007 In muscle, force emerges from myosin binding with actin (forming a cross-bridge). This actomyosin binding depends upon myofilament geometry, kinetics of thin-filament Ca(2+) activation, and kinetics of cross-bridge cycling.
Bertrand C W Tanner +2 more
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Myosin-based regulation of twitch and tetanic contractions in mammalian skeletal muscle
eLife, 2021 Time-resolved X-ray diffraction of isolated fast-twitch muscles of mice was used to show how structural changes in the myosin-containing thick filaments contribute to the regulation of muscle contraction, extending the previous focus on regulation by the
Cameron Hill +4 more
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Head-head interactions of resting myosin crossbridges in intact frog skeletal muscles, revealed by synchrotron x-ray fiber diffraction. [PDF]
PLoS ONE, 2012 The intensities of the myosin-based layer lines in the x-ray diffraction patterns from live resting frog skeletal muscles with full thick-thin filament overlap from which partial lattice sampling effects had been removed were analyzed to elucidate the ...
Kanji Oshima +3 more
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Force Measurements From Myofibril to Filament
Frontiers in Physiology, 2022 Contractility, the generation of force and movement by molecular motors, is the hallmark of all muscles, including striated muscle. Contractility can be studied at every level of organization from a whole animal to single molecules.
Steven Marston
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THICK FILAMENTS IN VASCULAR SMOOTH MUSCLE [PDF]
The Journal of Cell Biology, 1971 Two sets of myofilaments were demonstrated after incubation of strips of rabbit portal-anterior mesenteric vein under moderate stretch in a physiological salt solution. Thick filaments had a mean diameter of 18 nm and reached a maximum length of 1.4 µm with a mean length of 0.61 µm.
C E, Devine, A P, Somlyo
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Journal of Limnology, 2016 Recent studies have shown that the filamentous cyanobacterium Aphanizomenon gracile Lemmermann, strain SAG 31.79, consists of two types of filaments that differ in thickness.
Lukasz Wejnerowski +3 more
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