Results 61 to 70 of about 424,053 (243)

New AI‐Assisted Approach for Expanding the Solution Space: Application to Lattice Structure Design

Advanced Engineering Materials, EarlyView.
This work introduces an innovative framework for designing structured materials by ex panding the design space through reparameterization of qualitative variables into continuous structural descriptors. Combined with machine‐learning‐based prediction and multi‐objective optimization, the approach enables the discovery of novel lattice architectures ...
G. H. Gahimbare, Y. Beideler, D. Chune, R. De Guio, T. Roland, H. Chibane   +5 more
wiley   +1 more source

Developmental remodelling of Drosophila flight muscle sarcomeres: a scaled myofilament lattice model based on multiscale morphometrics

Open Biology
The indirect flight muscle is a widely used model for studying sarcomere structure and muscle development due to its extremely regular architecture. Nevertheless, precise measurement of the basic sarcomeric parameters remains a challenge even in this ...
Péter Görög, Tibor Novák, Tamás F. Polgár, Péter Bíró, Adél Gutheil, Csaba Kozma, Tamás Gajdos, Krisztina Tóth, Alexandra Tóth, Miklós Erdélyi, József Mihály, Szilárd Szikora   +11 more
doaj   +1 more source

Titin-mediated thick filament activation, through a mechanosensing mechanism, introduces sarcomere-length dependencies in mathematical models of rat trabecula and whole ventricle

Scientific Reports, 2017
Recent experimental evidence in skeletal muscle demonstrated the existence of a thick-filament mechanosensing mechanism, acting as a second regulatory system for muscle contraction, in addition to calcium-mediated thin filament regulation.
Lorenzo Marcucci, Takumi Washio, Toshio Yanagida   +2 more
doaj   +1 more source

Direct Measurement of Single Synthetic Vertebrate Thick Filament Elasticity Using Nanofabricated Cantilevers [PDF]

, 2002
Thick filaments are generally thought to be effectively inextensible. Here we use novel nanofabricated cantilevers to carry out the first direct force-elongation measurements on single vertebrate thick filaments.
Pollack, Gerald, Fauver, Mark, Dunaway, Dwayne   +2 more
core   +1 more source

Additive Manufacturing of Alumina‐Reinforced Elastomers

Advanced Engineering Materials, EarlyView.
Vat‐photopolymerized elastomers reinforced with platelet‐shaped alumina exhibited preferential orientation, reduced porosity, and significantly enhanced mechanical performance. A 3 wt% platelet loading increased tensile strength from 12.4 to 45.7 MPa, highlighting the critical role of filler morphology in elastomeric VPP composites.
Majid Barzegar Keyvani, Zongwen Fu, Robert Göstl, Hamed Shokri, Carmine Putignano, Gianluca Percoco, Bilal Gökce   +6 more
wiley   +1 more source

Alterations in thin filament length during postnatal skeletal muscle development and aging in mice

Frontiers in Physiology, 2014
The lengths of the sarcomeric thin filaments vary in a skeletal muscle-specific manner and help specify the physiological properties of skeletal muscle.
David S Gokhin, Emily A Dubuc, Kendra Q Lian, Luanne L Peters, Velia M Fowler   +4 more
doaj   +1 more source

Dictyostelium myosin bipolar thick filament formation: importance of charge and specific domains of the myosin rod. [PDF]

PLoS Biology, 2004
Myosin-II thick filament formation in Dictyostelium is an excellent system for investigating the phenomenon of self-assembly, as the myosin molecule itself contains all the information required to form a structure of defined size. Phosphorylation of only
Daniel Hostetter, Sarah Rice, Sara Dean, David Altman, Peggy M McMahon, Shirley Sutton, Ashutosh Tripathy, James A Spudich   +7 more
doaj   +1 more source

OntOMat: Toward Ontology‐Based Product and Process Design Engineering and Optimization Solutions Fueling Circular Value Chains

Advanced Engineering Materials, EarlyView.
The OntOMat ontology establishes a structured framework for polymer matrix fiber reinforced composite materials, integrating manufacturing processes, characterization methods, and multiscale design through the VDI/VDE 3682 formalized process description standard.
Nicolas Christ, Jörg Hohe, Martin Kördel, Michael Giese, Niklas Toffert, Christian Seidel, Olaf Rehme, Patrik Schneider, Oliver Focke, Elie Abi Aoun, Claas Falldorf, Beñat Gutierrez, Alexandra Kühn, Sven Torstrick-von der Lieth, Christoph Herden, Erik Johannsen, Jan‐Uwe R. Schmidt, Felix Winkelmann, Andreas Schott, Daniel Schott   +19 more
wiley   +1 more source

Cryo-EM structures of cardiac muscle α-actin mutants M305L and A331P give insights into the structural mechanisms of hypertrophic cardiomyopathy

European Journal of Cell Biology
Cardiac muscle α-actin is a key protein of the thin filament in the muscle sarcomere that, together with myosin thick filaments, produce force and contraction important for normal heart function.
Hsiang-Ling Huang, Andrejus Suchenko, Giovanna Grandinetti, Mohan K. Balasubramanian, Krishna Chinthalapudi, Sarah M. Heissler   +5 more
doaj   +1 more source

The Intriguing Dual Lattices of the Myosin Filaments in Vertebrate Striated Muscles: Evolution and Advantage

Biology, 2014
Myosin filaments in vertebrate striated muscle have a long roughly cylindrical backbone with cross-bridge projections on the surfaces of both halves except for a short central bare zone. In the middle of this central region the filaments are cross-linked
Pradeep K. Luther, John M. Squire
doaj   +1 more source