Results 51 to 60 of about 424,053 (243)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Microstructure Reconstruction in Battery Electrodes Using Machine Learning Based on Low‐Voltage Focused Ion Beam–Scanning Electron Microscopy Tomography Images

Advanced Engineering Materials, EarlyView.
Low‐voltage FIB‐SEM tomography combined with a image preprocessing pipeline improves phase contrast and enables reliable machine‐learning segmentation of conductive networks in lithium‐ion battery electrodes. Structural descriptors are extracted from segmented images, done semimanually and automated, and compared.
Lisa Beran, Vincent Nebel, Dominik Perius, Kshitij Kumar, Yannis Heim, Laura Bies, Tobias Kraus   +6 more
wiley   +1 more source

Genetic dissection of novel myopathy models reveals a role of CapZα and Leiomodin 3 during myofibril elongation.

PLoS Genetics, 2022
Myofibrils within skeletal muscle are composed of sarcomeres that generate force by contraction when their myosin-rich thick filaments slide past actin-based thin filaments.
Joachim Berger, Silke Berger, Yu Shan G Mok, Mei Li, Hakan Tarakci, Peter D Currie   +5 more
doaj   +1 more source

Myofilin, a protein in the thick filaments of insect muscle [PDF]

Journal of Cell Science, 2005
Thick filaments in striated muscle are myosin polymers with a length and diameter that depend on the fibre type. In invertebrates, the length of the thick filaments varies widely in different muscles and additional proteins control filament assembly.
Feng, Qiu, Sigrun, Brendel, Paulo M F, Cunha, Nagore, Astola, Bauzhen, Song, Eileen E M, Furlong, Kevin R, Leonard, Belinda, Bullard   +7 more
openaire   +2 more sources

cucapra/filament-evaluation: Initial artifact release

, 2023
Test release for the Filament ...
Rachit Nigam
core   +1 more source

Comparison of Triply Periodic Minimal Surface Energy Absorbers Under Uniaxial Compressive Loading

Advanced Engineering Materials, EarlyView.
This study investigates LCD 3D printed Triply Periodic Minimal Surface (TPMS) structures as mechanical energy absorbers. By comparing various base designs and layered combinations under uniaxial compression, it identifies that a Diamond‐Gyroid sandwich structure offers superior performance.
Sergej Grednev, Noah‐Lean Roschlaub, Anne Jung   +2 more
wiley   +1 more source

Maturational Changes in Cerebrovascular Thick- and Thin-Filament Regulation [PDF]

, 2007
The present study focused on the main hypothesis that age-related changes in myofilament Ca2+ sensitivity involve simultaneous changes in the relations between cytosolic Ca2+ transients, myosin phosphorylation, and force development.
Sandoval, Renan Joel
core   +1 more source

Interaction of cardiac leiomodin with the native cardiac thin filament.

PLoS Biology
Every heartbeat depends on cyclical contraction-relaxation produced by the interactions between myosin-containing thick and actin-based thin filaments (TFs) arranged into a crystalline-like lattice in the cardiac sarcomere.
Madison Little, Cristina M Risi, Tania M Larrinaga, Mason D Summers, Tyler Nguyen, Garry E Smith, Jennifer Atherton, Carol C Gregorio, Alla S Kostyukova, Vitold E Galkin   +9 more
doaj   +1 more source

Performance of miniaturised thick-film solid state pH sensors [PDF]

, 2012
The performance of novel solid-state Thick-Film pH sensor for water quality sampling suitable for deployment in remote catchment areas is described. These miniaturised screen printed planar pH sensors are an alternative to glass pH electrodes, which have
Atkinson, John, Glanc-Gostkiewicz, M., Atkinson, J.K., Sophocleous, Marios, Garcia-Breijo, Eduardo, Sophocleous, M., Glanc, M., Atkinson, John Karl, Glanc-Gostkiewicz, Monika, Garcia-Breijo, E., Garcia Breijo, Eduardo   +10 more
core   +1 more source