Results 151 to 160 of about 1,373 (204)

Design, synthesis and evaluation of thiohydantoin derivatives as potent topoisomerase I (Top1) inhibitors with anticancer activity

European Journal of Medicinal Chemistry, 2015
DNA topoisomerase I is a potential chemotherapeutic target. Here, we designed and synthesized a library comprising of hydantoin and thiohydantoin derivatives and tested them against human and Leishmania Top1.
Chandramohan Bathula, Subhabrata Sen, Rahul Agarwal   +2 more
exaly   +2 more sources

Novel and efficient protocol for the syntheses of N-1 substituted thiohydantoin and a bicyclothiohydantoin under solvent-free conditions

Tetrahedron Letters, 2012
A novel approach for the synthesis of N-1 substituted thiohydantoin has been developed to give quantitative yields of the desired products. The efficient synthesis of bis-thiohydantoin derivative and bicyclothiohydantoin has extended scope and ...
M P Kaushik
exaly   +2 more sources

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Thiohydantoins. VI. Hydrolysis of 1-acyl-2-thiohydantoins: reported anomalies

Canadian Journal of Chemistry, 1968
Two reports in which it was claimed that the 1-acyl group of a 1-acyl-2-thiohydantoin was not rapidly removed by dilute acid or alkali were investigated and found erroneous.
J. T. Edward, J. K. Liu
openaire   +1 more source

Facile Synthesis of 5-Arylidene Thiohydantoin by Sequential Sulfonylation/Desulfination Reaction

International Journal of Molecular Sciences, 2013
The sequential sulfonylation/desulfination reactions of 5-benzylthiohydantoin with excess arylsulfonyl chlorides in the presence of triethylamine have been developed to afford a wide range of 5-arylidene thiohydantoin derivatives in moderate to excellent
Mingan Wang, Hongbo Dong, Jintao Han
exaly   +2 more sources

Thiohydantoins. VII. Ionization and ultraviolet spectra of 4-thiohydantoins and 2,4-dithiohydantoins

Canadian Journal of Chemistry, 1969
The acid and base dissociation constants of 5,5-pentamethylene-4-thiohydantoin, 5,5-pentamethylene-2,4-dithiohydantoin, and their 1-methyl derivatives, have been determined by ultraviolet studies in basic and acid media. In aqueous sulfuric acid the 4-thiohydantoins are protonated on oxygen at the 2-position, so that the extent of protonation varies ...
J. T. Edward, J. K. Liu
openaire   +1 more source

Design, Synthesis, and Biological Activity of β-Carboline Analogues Containing Hydantoin, Thiohydantoin, and Urea Moieties

Journal of Agricultural and Food Chemistry, 2018
A series of novel β-carboline derivatives was designed by combining the anti-tobacco mosaic virus (TMV) lead compound tetrahydro-β-carboline ester with the hydantoin, thiohydantoin, and urea motifs.
Hongjian Song, Qingmin Wang, Yuxiu Liu   +2 more
exaly   +2 more sources

Synthesis of 5-Chloromethylene Hydantoins and Thiohydantoins

HETEROCYCLES, 2007
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Timothy A. Cernak, James L. Gleason
openaire   +1 more source

Thiohydantoins. X. Kinetic Studies of the Acid Hydrolysis of 1-Acyl-2-thiohydantoins

Canadian Journal of Chemistry, 1972
The rates of hydrolysis of 22 1-acyl-2-thiohydantoins in aqueous sulfuric acid to give 2-thiohydantoin and a carboxylic acid have been determined. In 0–90% sulfuric acid, hydrolysis takes place by an A-2 mechanism, and the rate reaches a maximum in about 70% acid.
Wayne Irvine Congdon, John Thomas Edward
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Thiohydantoins. II. Thiohydantoins Derived from Aspartic and Glutamic Acids

Australian Journal of Scientific Research Series A: Physical Sciences, 1952
N-Acyl derivatives of the &carboxylic acids, aspartic and glutamic acids, yield the corresponding anhydrides when heated with acetic anhydride in the presence or absence of ammonium thiocyanate. In general these anhydrides form isomeric pairs of amides and anilides, and only one of each pair can be converted into the corresponding 2-thiohydantoin ...
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Thiohydantoins. XI Kinetic Studies of the Alkaline Hydrolysis of 1-Acyl-2-thiohydantoins

Canadian Journal of Chemistry, 1972
1-Acyl-2-thiohydantoins ionize in alkaline solution (pK ∼ 7). In solutions more alkaline than pH > 11 they are rapidly hydrolyzed to 2-thiohydantoin and a carboxylic acid, by attack of a hydroxide ion on the conjugate base of the 1-acyl-2-thiohydantoin.
Wayne I. Congdon, John T. Edward
openaire   +1 more source