Results 21 to 30 of about 2,082 (147)

A recent update on new synthetic chiral compounds with antileishmanial activity

Chirality, Volume 34, Issue 10, Page 1279-1297, October 2022., 2022
∎ Abstract Parasitic diseases, including malaria, leishmaniasis, and trypanosomiasis, affect billions of people and are responsible for almost 500,000 deaths/year. In particular, leishmaniasis, a neglected tropical disease, is considered a global public health problem because current drugs have several drawbacks including to toxicity, high cost, and ...
Michele Verboni, Diego Olivieri, Simone Lucarini   +2 more
wiley   +1 more source

5-[(1,3-Dimethyl-5-oxo-2-sulfanylideneimidazolidin-4-ylidene)amino]-2-methylisoindoline-1,3-dione

IUCrData, 2021
The title N,N-dimethylthiohydantoin containing an N-methylated pthalimide group, C14H12N4O3S, arose from an unexpected reaction in a deep eutectic dimethylthiourea–tartaric acid solvent system.
Sambasivarao Kotha, Naveen Kumar Gupta, Saima Ansari   +2 more
doaj   +1 more source

Design, synthesis, and characterization of PROTACs targeting the androgen receptor in prostate and lung cancer models

Archiv der Pharmazie, Volume 355, Issue 5, May 2022., 2022
Structurally distinct enzalutamide‐based proteolysis‐targeting chimeras (PROTACs) were designed, synthesized, and biochemically analyzed. For the first time, androgen receptor degraders were evaluated in lung cancer cells, where significant degradation of the target was observed.
Lukas M. Gockel, Vladlena Pfeifer, Fabian Baltes, Rafael D. Bachmaier, Karl G. Wagner, Gerd Bendas, Michael Gütschow, Izidor Sosič, Christian Steinebach   +8 more
wiley   +1 more source

Glycogen phosphorylase inhibitor N-(3,5-dimethyl-benzoyl)-N'-(β-Dglucopyranosyl) urea improves glucose tolerance under normoglycemic and diabetic conditions and rearranges hepatic metabolism [PDF]

, 2013
Glycogen phosphorylase (GP) catalyzes the breakdown of glycogen and largely contributes to hepatic glucose production making GP inhibition an attractive target to modulate glucose levels in diabetes.
Bai, Péter, Brunyánszki, Attila, Docsa, Tibor, Gergely, Pál, Hegedűs, Csaba, Kónya, Bálint, Márton, Judit, Nagy, Lilla, Somsák, László, Szántó, Magdolna, Virág, László   +10 more
core   +5 more sources

(Z)-2′-((Adamantan-1-yl)thio)-1,1′-dimethyl-2′,3′-dihydro-[2,4′-biimidazolylidene]-4,5,5′(1H,1′H,3H)-trione

Molbank, 2023
The title compound, (Z)-2′-((adamantan-1-yl)thio)-1,1′-dimethyl-2′,3′-dihydro-[2,4′-biimidazolylidene]-4,5,5′(1H,1′H,3H)-trione, was found to be a by-product of the reaction of 1,3-dehydroadamantane with 3-methyl-2-thioxoimidazolidin-4-one and ...
Vladimir Burmistrov, Vladimir Mokhov, Robert R. Fayzullin, Gennady M. Butov   +3 more
doaj   +1 more source

Kinetic investigation of reactions of a 3-arylidene-2-thiohydantoin derivative with palladium (II) salts [PDF]

Journal of the Serbian Chemical Society
1H-NMR spectroscopy was used to monitor the reactions of an arylidene 2-thiohydantoin derivative, 3-((phenylmethylene)amino)-2-thioxo-4-imidazolidinone (3), with PdCl2, cis-[PdCl2(dmso-S)2] and K2[PdCl4] in DMSO-d6 in order to elucidate the reaction ...
Stanić Petar B., Ašanin Darko P., Soldatović Tanja V., Živković Marija D.   +3 more
doaj   +1 more source

Cu(I) Arylsulfonate π-Complexes with 3-Allyl-2-thiohydantoin: The Role of the Weak Interactions in Structural Organization

Acta Chimica Slovenica, 2020
The present work is directed toward preparation and structural characterization of two novel Cu(I) arylsulfonate π-complexes with 3-allyl-2-thiohydantoin, namely [Cu2(Hath)4](C6H5SO3)2 (1) and [Cu2(Hath)4](p-CH3C6H4SO3)2·2H2O (2) (Hath = 3-allyl-2 ...
Andrii Fedorchuk, Evgeny Goreshnik, Yurii Slyvka, Marian Mys’kiv   +3 more
doaj   +1 more source

Inhibiting tryptophan metabolism enhances interferon therapy in kidney cancer. [PDF]

, 2016
Renal cell carcinoma (RCC) is increasing in incidence, and a complete cure remains elusive. While immune-checkpoint antibodies are promising, interferon-based immunotherapy has been disappointing.
Abu Aboud, Omran, Anderson, Katie, Berryhill, Grace, Chen, Ching-Hsien, Graef, Ashley, Hovey, Russell C, Kim, Jeffrey, Modiano, Jaime F, Sarver, Aaron L, Stewart, Benjamin, Trott, Josephine F, Uzal, Francisco, Weiss, Robert H, Wettersten, Hiromi   +13 more
core   +2 more sources

Synthesis and Fluorescence Mechanism of the Aminoimidazolone Analogues of the Green Fluorescent Protein: Towards Advanced Dyes with Enhanced Stokes Shift, Quantum Yield and Two‐Photon Absorption

European Journal of Organic Chemistry, Volume 2021, Issue 41, Page 5649-5660, November 8, 2021., 2021
Intramolecularly hydrogen‐bonded analogues of the green fluorescence protein chromophore with an aminoimidazole moiety were synthesised and characterised. The fluorescence mechanism and substituent effects were investigated in a combined experimental‐computational approach, and a 279‐fold improvement in the quantum yield was realised.
Ervin Kovács, Levente Cseri, Attila Jancsó, Ferenc Terényi, Anna Fülöp, Balázs Rózsa, Gábor Galbács, Zoltán Mucsi   +7 more
wiley   +1 more source

Synthesis of hydantoin and thiohydantoin related compounds from benzil and study of their cytotoxicity [PDF]

Bangladesh Journal of Pharmacology, 2006
Condensation of benzil (1) with urea, monophenyl urea and diphenyl urea in the presence of absolute ethanol using 30% aqueous NaOH gave the products 1a, 1b and 1c respectively and also with thiourea, monomethyl thiourea, dimethyl thiourea and diethyl ...
A. Kashem Liton and M. Rabiul Islam
doaj   +4 more sources