A Plausible Prebiotic One-Pot Synthesis of Orotate and Pyruvate Suggestive of Common Protometabolic Pathways. [PDF]
Angew Chem Int Ed Engl, 2022 A prebiotic synthesis of the nucleobase orotate, and the citric acid cycle intermediate pyruvate, proceeds in a single pot from two small glycine derivatives, hydantoin and glyoxylate, under mild aqueous conditions. These findings support a co‐evolution of pathways to core protometabolites and nucleic acid building blocks in a common environment ...
Clay AP +5 more
europepmc +3 more sources
Synthesis and Identification of Heterobivalent Anticancer Compounds Containing Urea and 5-Arylidene-2-Thiohydantoin Motifs. [PDF]
ChemistrySelectA synthetic approach to the synthesis of novel heterobivalent compounds containing urea and 5‐arylthiohydantoin groups was developed for the preparation of a mixture‐based library. Through the screening and deconvolution of the library, six hits with βC branched residues at R1 and imidazyl residue at R3 were identified exhibiting moderate inhibitory ...
Whitely C, Winburn H, Li Y.
europepmc +2 more sources
Reaction of a 3-aryilidene-2-thiohydantoin derivative with polymeric trans-[CuCl2(DMSO)2]n complex: Unexpected isomerization to dinuclear cis-[{CuCl(DMSO)2}(μ-Cl)]2 [PDF]
Journal of the Serbian Chemical Society, 2020 The 3-arylidene-2-thiohydantoin derivative, 3-[(2-hydroxybenzylidene) amino]-2-thioxoimidazolidin-4-one, was synthesized in a two-step condensation reaction of 2-hydroxybenzaldehyde, thiosemicarbazide and ethyl chloroacetate.
Stanić Petar B. +6 more
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One-Pot Gateway to Quinazoline–Thiohydantoin Fused Scaffolds and Discovery of Their Antileukemic Activity [PDF]
JACS AuLena Kersting +13 more
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Synthesis and characterization of selected fused isoxazole and pyrazole derivatives and their antimicrobial activity [PDF]
Journal of the Serbian Chemical Society, 2009 New potent antibacterials, fused isoxazole and pyrazole derivatives, were synthesized using 5,5-dimethylcyclohexane-1,3-dione (1) and 3-[(4-chlorobenzylidene) amino]-2-thioxoimidazolidin-4-one (2) as synthons.
Dabholkar Vijay V., Ansari Faisal Y.
doaj +3 more sources
SYNTHESES, ANTIMICROBIAL ACTIVITY AND MASS SPECTRAl INVESTIGATION OF SOME NEW THIOHYDANTOIN AND THIAZOLE DERIVATIVES. [PDF]
Al-Azhar Journal of Pharmaceutical Sciences, 2012 5-(p-Tolyl)-2-[(p-tolylethylidene)hydrazino] thiazole (3) and 3-[(p-tolylethylidene )amino]-2-thiohydantoin (6) have been prepared via cyclization of p-methyl acetophenone thiosemicarbazone (2) with p-methylphenacyl bromide and ethyl chloroacetate ...
haba Abd El Hady
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ANTITHYROID ACTIVITY OF THIOHYDANTOINS [PDF]
British Journal of Pharmacology and Chemotherapy, 1958 The antithyroid activity of 2‐thiohydantoin and some derivatives has been measured in rats, after a single dose and, also, after daily administration for 6 weeks. 2‐Thiohydantoin and its 5‐alkyl derivatives from 5‐methyl to 5‐sec‐butyl‐ showed considerable antithyroid activity at a dose of 0.05 m.mole/kg.
R, KILPATRICK, D T, ELMORE, D R, WOOD
openaire +2 more sources
Fluorous Synthesis of Hydantoins and Thiohydantoins. [PDF]
ChemInform, 2003 AbstractFor Abstract see ChemInform Abstract in Full Text.
Wei, Zhang, Yimin, Lu
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IUCrData, 2023 The title molecule, C23H26N2O4S, adopts a cup-shaped conformation. In the crystal, layers lying parallel to the ab plane are formed by C—H...O hydrogen bonds and C—H...π(ring) interactions.
Walid Guerrab +4 more
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The Chemical Record, Volume 23, Issue 11, November 2023., 2023 Efforst are described for developing Brønsted base‐catalyzed, site‐ and stereoselective α‐functionalization of a variety of unsaturated enolizable carbonyl compounds via transient enolates featuring an extended π‐system. Abstract Chiral Brønsted base (BB) catalyzed asymmetric transformations constitute an important tool for synthesis.
Mikel Oiarbide, Claudio Palomo
wiley +1 more source