Results 21 to 30 of about 873 (170)
European Journal of Organic Chemistry, Volume 2022, Issue 40, October 26, 2022., 2022 A new strategy has been proposed for the synthesis of an array of imidazo[5,1‐c][1,4]oxazine chemotypes by using a planned aza‐Michael addition in a 3‐CR heteroring‐forming, post‐cyclization transformation followed by an intramolecular fused‐heterocycles formation process.
Giacomo Mari +4 more
wiley +1 more source
A recent update on new synthetic chiral compounds with antileishmanial activity
Chirality, Volume 34, Issue 10, Page 1279-1297, October 2022., 2022 ∎ Abstract Parasitic diseases, including malaria, leishmaniasis, and trypanosomiasis, affect billions of people and are responsible for almost 500,000 deaths/year. In particular, leishmaniasis, a neglected tropical disease, is considered a global public health problem because current drugs have several drawbacks including to toxicity, high cost, and ...
Michele Verboni +2 more
wiley +1 more source
Kinetic investigation of reactions of a 3-arylidene-2-thiohydantoin derivative with palladium (II) salts [PDF]
Journal of the Serbian Chemical Society1H-NMR spectroscopy was used to monitor the reactions of an arylidene 2-thiohydantoin derivative, 3-((phenylmethylene)amino)-2-thioxo-4-imidazolidinone (3), with PdCl2, cis-[PdCl2(dmso-S)2] and K2[PdCl4] in DMSO-d6 in order to elucidate the reaction ...
Stanić Petar B. +3 more
doaj +1 more source
5-[(1,3-Dimethyl-5-oxo-2-sulfanylideneimidazolidin-4-ylidene)amino]-2-methylisoindoline-1,3-dione
IUCrData, 2021 The title N,N-dimethylthiohydantoin containing an N-methylated pthalimide group, C14H12N4O3S, arose from an unexpected reaction in a deep eutectic dimethylthiourea–tartaric acid solvent system.
Sambasivarao Kotha +2 more
doaj +1 more source
Archiv der Pharmazie, Volume 355, Issue 5, May 2022., 2022 Structurally distinct enzalutamide‐based proteolysis‐targeting chimeras (PROTACs) were designed, synthesized, and biochemically analyzed. For the first time, androgen receptor degraders were evaluated in lung cancer cells, where significant degradation of the target was observed.
Lukas M. Gockel +8 more
wiley +1 more source
Molbank, 2023 The title compound, (Z)-2′-((adamantan-1-yl)thio)-1,1′-dimethyl-2′,3′-dihydro-[2,4′-biimidazolylidene]-4,5,5′(1H,1′H,3H)-trione, was found to be a by-product of the reaction of 1,3-dehydroadamantane with 3-methyl-2-thioxoimidazolidin-4-one and ...
Vladimir Burmistrov +3 more
doaj +1 more source
Acta Chimica Slovenica, 2020 The present work is directed toward preparation and structural characterization of two novel Cu(I) arylsulfonate π-complexes with 3-allyl-2-thiohydantoin, namely [Cu2(Hath)4](C6H5SO3)2 (1) and [Cu2(Hath)4](p-CH3C6H4SO3)2·2H2O (2) (Hath = 3-allyl-2 ...
Andrii Fedorchuk +3 more
doaj +1 more source
European Journal of Organic Chemistry, Volume 2021, Issue 41, Page 5649-5660, November 8, 2021., 2021 Intramolecularly hydrogen‐bonded analogues of the green fluorescence protein chromophore with an aminoimidazole moiety were synthesised and characterised. The fluorescence mechanism and substituent effects were investigated in a combined experimental‐computational approach, and a 279‐fold improvement in the quantum yield was realised.
Ervin Kovács +7 more
wiley +1 more source
Synthesis of hydantoin and thiohydantoin related compounds from benzil and study of their cytotoxicity [PDF]
Bangladesh Journal of Pharmacology, 2006 Condensation of benzil (1) with urea, monophenyl urea and diphenyl urea in the presence of absolute ethanol using 30% aqueous NaOH gave the products 1a, 1b and 1c respectively and also with thiourea, monomethyl thiourea, dimethyl thiourea and diethyl ...
A. Kashem Liton and M. Rabiul Islam
doaj +4 more sources
Acta Chimica Slovenica, 2015 Synthesis and characterization of new Pt(II) complexes of cyclohexanespiro-5-(2-thiohydantoin) (L1) and cycloheptanespiro-5-(2-thiohydantoin) (L2) are discussed. The new complexes are studied by elemental analysis, IR, ATR FTIR spectroscopy.
Petja E. Marinova +3 more
doaj +1 more source