Results 31 to 40 of about 1,246 (203)

Synthesis and Fluorescence Mechanism of the Aminoimidazolone Analogues of the Green Fluorescent Protein: Towards Advanced Dyes with Enhanced Stokes Shift, Quantum Yield and Two‐Photon Absorption

European Journal of Organic Chemistry, Volume 2021, Issue 41, Page 5649-5660, November 8, 2021., 2021
Intramolecularly hydrogen‐bonded analogues of the green fluorescence protein chromophore with an aminoimidazole moiety were synthesised and characterised. The fluorescence mechanism and substituent effects were investigated in a combined experimental‐computational approach, and a 279‐fold improvement in the quantum yield was realised.
Ervin Kovács, Levente Cseri, Attila Jancsó, Ferenc Terényi, Anna Fülöp, Balázs Rózsa, Gábor Galbács, Zoltán Mucsi   +7 more
wiley   +1 more source

Synthesis of hydantoin and thiohydantoin related compounds from benzil and study of their cytotoxicity [PDF]

Bangladesh Journal of Pharmacology, 2006
Condensation of benzil (1) with urea, monophenyl urea and diphenyl urea in the presence of absolute ethanol using 30% aqueous NaOH gave the products 1a, 1b and 1c respectively and also with thiourea, monomethyl thiourea, dimethyl thiourea and diethyl ...
A. Kashem Liton and M. Rabiul Islam
doaj   +4 more sources

Synthesis and Biological Evaluation of Dantrolene‐Like Hydrazide and Hydrazone Analogues as Multitarget Agents for Neurodegenerative Diseases

ChemMedChem, Volume 16, Issue 18, Page 2807-2816, September 16, 2021., 2021
Simpler is better: Structural modifications of the chemical structure of dantrolene, previously disclosed as a repositionable drug with potential for Alzheimer's disease, allowed preparing new small molecules with multitarget activity profile. Compared to dantrolene, molecular simplification resulted in less toxic and more soluble compounds.
Isabella Bolognino, Nicola Giangregorio, Annamaria Tonazzi, Antón L. Martínez, Cosimo D. Altomare, María I. Loza, Sara Sablone, Saverio Cellamare, Marco Catto   +8 more
wiley   +1 more source

New platinum(II) complexes of cycloalkanespiro-5-(2-thiohydantoins). Synthesis and quantum chemical investigation

Acta Chimica Slovenica, 2015
Synthesis and characterization of new Pt(II) complexes of cyclohexanespiro-5-(2-thiohydantoin)  (L1) and cycloheptanespiro-5-(2-thiohydantoin) (L2) are discussed. The new complexes are studied by elemental analysis, IR, ATR FTIR spectroscopy.
Petja E. Marinova, Marin Marinov, Vassil Delchev, Neyko Stoyanov   +3 more
doaj   +1 more source

A New Polymorph of 2-Thiohydantoin

X-ray Structure Analysis Online, 2009
A new polymorphic crystal of the title compound, C3H4N2OS, belongs to space group P1 with cell dimensions of a = 4.0520(9)A, b = 6.550(1)A, c = 9.170(2)A, α = 100.148(4)°, β = 100.814(4)°, γ = 96.831(4)°, R1 = 0.069. Neighboring molecules are connected to form cyclic dimers via two types of hydrogen bonds, one between the thioamide groups and the other
Ogawa, Toshikazu, Okumura, Hisako, Honda, Mitsunori, Suda, Mitsuhiro, Fujinami, Shuhei, Kuwae, Akio, Hanai, Kazuhiko, Kunimoto, Ko-Ki   +7 more
openaire   +2 more sources

Synthesis and antibacterial activity of new (2,4-dioxothiazolidin-5-yl/ylidene)acetic acid derivatives with thiazolidine-2,4-dione, rhodanine and 2-thiohydantoin moieties

Saudi Pharmaceutical Journal, 2018
A series of new (2,4-dioxothiazolidin-5-yl/ylidene)acetic acid derivatives with thiazolidine-2,4-dione, rhodanine and 2-thiohydantoin moiety (28–65) were synthesized by the reaction of (2,4-dioxothiazolidin-5-yl/ylidene)acetic acid chlorides with 5 ...
Nazar Trotsko, Urszula Kosikowska, Agata Paneth, Monika Wujec, Anna Malm   +4 more
doaj   +1 more source

Heterocyclic systems containing S/N regioselective nucleophilic competition: Facile synthesis, antitubercular and antimicrobial activity of thiohydantoins and iminothiazolidinones containing the benzo [PDF]

Journal of the Serbian Chemical Society, 2005
The required compounds N-aryl-N'-(3-chloro-2-benzo[b]thenoyl)-thioureas 1a-k were prepared by condensing 3-chloro-2-benzo[b]thenoyl chloride with different arylamines using ammonium thiocyanate, which in turn when treated with chloroacetic acid, yielded ...
Kachhadia V.V., Patel M.R., Joshi H.S.
doaj   +1 more source

Synthetical Application of Alkyl 2-isothiocyanatocarboxylates. A Simple Synthesis of 5-Substituted-3-amino-2-thioxo-4-imidazolidinones (3-Amino-2-thiohydantoins)

Molecules, 1999
The title 3-amino-2-thiohydantoins 3 has been prepared in very good yields by the reaction of alkyl isothiocynatocarboxylates 1 with hydrazine hydrate.The synthesis of starting isothiocyanates as well as spectral data of 3-aminothiohydantoins and alkyl ...
Martin Kovac, Vladimir Oremus, Lubomir Floch   +2 more
doaj   +1 more source

Elucidation of the Atroposelectivity in the Synthesis of Axially Chiral Thiohydantoin Derivatives

, 2020
Recently, Sarigul and Dogan have synthesized a number of enantiomerically enriched axially chiral atropoisomeric 2-thiohydantoins by the reaction of L-amino acid ester salts and o-aryl isothiocyanates in the presence of triethyl amine (TEA) in ...
Zeynep Pinar Haslak, Agopcan Cinar, Sesil, Dogan, Ilknur, Ilknur Dogan (2498668), Haslak, Zeynep,, Viktorya Aviyente, Aviyente, Viktorya, Sevgi Sarigul Ozbek (8317449), Sarigul Ozbek, Sevgi, Sesil Agopcan Cinar, Zeynep Pinar Haslak (4510531), Ilknur Dogan, Monard, Gérald, Viktorya Aviyente (775638), Gérald Monard (8317452), Gérald Monard, Sevgi Sarigul Ozbek, Sesil Agopcan Cinar (8317446)   +17 more
core   +1 more source

Effect of Microwave Irradiation on the Condensation of 6-Substituted 3-Formylchromones with Some Five-membered Heterocyclic Compounds

Molecules, 2000
Different types of 3-substituted 4H-4-oxobenzopyrans were prepared by microwave irradiation as well as by a classical method. The beneficial effect of microwave irradiation on the aldol condensation of 3-formylchromones with 2-imino-1-methylimidazolidine-
Nada Pronayova, Tibor Liptay, Dusan Loos, Renata Gasparova, Margita Lacova   +4 more
doaj   +1 more source