Results 51 to 60 of about 873 (170)

Necrostatin‐1 releasing nanoparticles: In vitro and in vivo efficacy for supporting immunoisolated islet transplantation outcomes

Journal of Biomedical Materials Research Part A, Volume 112, Issue 2, Page 288-295, February 2024.
Abstract Immunoisolation of pancreatic islets in alginate microcapsules allows for transplantation in the absence of immunosuppression but graft survival time is still limited. This limited graft survival is caused by a combination of tissue responses to the encapsulating biomaterial and islets. A significant loss of islet cells occurs in the immediate
Alexandra M. Smink, Juan D. Medina, Bart J. de Haan, Andrés J. García, Paul de Vos   +4 more
wiley   +1 more source

Synthesis and molecular modeling studies of new thiohydantoin-triazole hybrids as anticancer agents

Journal of Saudi Chemical Society
The targeted thiohydantoin-triazole hybrid compounds 5a-d and 9a-d were synthesized by the copper-catalyzed click reaction of 2-azido-N-arylacetamides 3a-d with the appropriate alkynes, thiohydantoin moiety linked to a propargyl group.
Wael M. Alamoudi
doaj   +1 more source

A comparison of the exposure system of glycidol‐related chemicals on the formation of glycidol‐hemoglobin adducts

Food Science &Nutrition, Volume 12, Issue 1, Page 471-480, January 2024.
The exposure systems of glycidol‐related chemicals on the formation of glycidol‐hemoglobin adducts diHOPrVal were compared. DiHOPrVal formation was observed using several chemicals other than glycidol with different behaviors in vitro and in vivo. However, in both cases, the amount of diHOPrVal produced was very small compared with glycidol. This study
Yuko Shimamura, Yuri Wada, Moeka Tashiro, Hiroshi Honda, Shuichi Masuda   +4 more
wiley   +1 more source

Facile regiodivergent synthesis of spiro pyrrole-substituted pseudothiohydantoins and thiohydantoins via reaction of [e]-fused 1H-pyrrole-2,3-diones with thiourea

Beilstein Journal of Organic Chemistry, 2019
A highly divergent synthesis of regioisomeric thiohydantoins and pseudothiohydantoins spiro-fused to a pharmacologically valuable pyrrole-2-one fragment involving the reaction of [e]-fused 1H-pyrrole-2,3-diones with thioureas was developed.
Aleksandr I. Kobelev, Nikita A. Tretyakov, Ekaterina E. Stepanova, Maksim V. Dmitriev, Michael Rubin, Andrey N. Maslivets   +5 more
doaj   +1 more source

Microwave Assisted Synthesis of Novel Functionalized Hydantoin Derivatives and Their Conversion to 5-(Z) Arylidene-4H-imidazoles

Molecules, 2011
2-(Alkyl-1-yl)-1H-imidazol-5(4H)-ones 5a–n were synthesized via nucleophilic substitution of the methylsulfanyl group of the corresponding 2-(methylthio)-1H-imidazol-5(4H)-ones 3a–c with suitably substituted secondary amines.
Edward R. Biehl, Haribabu Ankati, Sukanta Kamila   +2 more
doaj   +1 more source

Determination of Acid Dissociation Constants (pKa) of Bicyclic Thiohydantoin-Pyrrolidine Compounds in 20% Ethanol-Water Hydroorganic Solvent

International Journal of Analytical Chemistry, 2014
The acid dissociation constants of potential bioactive fused ring thiohydantoin-pyrrolidine compounds were determined by potentiometric titration in 20% (v/v) ethanol-water mixed at 25±0.1°C, at an ionic background of 0.1 mol/L of NaCl using the ...
Yahya Nural, H. Ali Döndaş, Hayati Sarı, Hasan Atabey, Samet Belveren, Müge Gemili   +5 more
doaj   +1 more source

Enobosarm in Muscle Wasting

JCSM Communications, Volume 9, Issue 1, January/June 2026.
Stephan von Haehling
wiley   +1 more source

Investigating the Kinetic Impact of DMSO on Platinum(II) Coordination: An Experimental and Computational Study of Cisplatin and 2-Thiohydantoin Ligands

Inorganics
This study presents a thorough investigation of chemical outcomes during the reaction of cisplatin and 2-thiohydantoin ligands in the presence of DMSO. Aided by NMR spectroscopy and quantum chemical calculations, the influence of DMSO substitution on the
Petar B. Stanić, Amina I. Nurović, Tanja V. Soldatović, Darko P. Ašanin, Marko V. Rodić, Biljana M. Šmit, Goran V. Janjić   +6 more
doaj   +1 more source

Progress on the Chemical Constituents Derived from Glucosinolates in Maca (Lepidium meyenii)

Natural Products and Bioprospecting, 2018
Maca (Lepidium meyenii Walp.), a famous food supplement, has drawn an unprecedented international interest over the last two decades. It was assumed that glucosinolates, macamides, macaenes, and alkaloids are the main bioactive components of Maca before.
Yan-Jie Huang, Xing-Rong Peng, Ming-Hua Qiu   +2 more
doaj   +1 more source

Studies in the Synthesis of Thiohydantoins: Part II. Derivatives of 3-(Benzothiazole-2-YL) Thiohydantoins

, 1975
Department of Chemistry, Sambalpur University, Sambalpur and Department of Chemistry, G. M. College, Sambalpur. Manuscript received 27 May 1972; accepted 4 July 1975. Several substituted benzothiazolyl thiohydantoias (I), their arylideae derivatives (II) and dibromo compounds (W) have been synthesised.
M. BEHERA, P. N. DHAL, A. NAYAK
openaire   +2 more sources