Results 101 to 110 of about 11,830 (209)

Clinical Pharmacogenetics Implementation Consortium Guidelines for Thiopurine Methyltransferase Genotype and Thiopurine Dosing

, 2011
Thiopurine methyltransferase (TPMT) activity exhibits monogenic co-dominant inheritance, with ethnic differences in the frequency of occurrence of variant alleles.
W E Evans, Relling, M V, K Schmiegelow, Klein, T E, M V Relling, E E Gardner, M Carrillo, C M Stein, W J Sandborn, Sandborn, W J, Yee, S W, Gardner, E E, C-H Pui, T E Klein, S W Yee, Schmiegelow, K, Pui, C-H, Carrillo, Maria Berrocal, Stein, Paul C., Evans, W E   +19 more
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Usefulness of thiopurine methyltransferase and thiopurine metabolite analysis in clinical practice in patients with inflammatory bowel diseases.

, 2010
Thiopurines (TP) are widely used in the management of inflammatory bowel diseases. Side-effects and inefficacy are a major concern as they lead to withdrawal of the drug.
Dewit, Olivier
core  

Let's get personal:predicting thiopurine and fluoropyrimidine toxicity

, 2012
The US FDA now recognizes the need to individualize treatment paradigms using biomarkers that predict response to therapy. In clinical practice the best example of this is TPMT testing, which is used to rationalize the starting dose of azathioprine and ...
Corrigan, Adele, Arenas-Hernandez, Monica, Marinaki, Anthony, Blaker, Paul, Sanderson, Jeremy   +4 more
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Blood-test monitoring strategies for patients established on immune-suppressing drugs: a mixed-methods study

Health Technology Assessment
Background The optimal monitoring strategy for adults with inflammatory conditions established on immune-suppressing treatment is unknown. Objectives To ascertain the optimum strategy of monitoring blood tests for patients established on immune ...
Abhishek Abhishek, Christopher Carroll, Munira Essat, Jo Leaviss, Georgina Nakafero, Amy Fuller, Matthew J Grainge, Jennie Hancox, Hywel C Williams, Timothy Card, Maarten W Taal, Guruprasad P Aithal, Christopher P Fox, Christian D Mallen, Kavita Vedhara, Danielle A van der Windt, Matthew D Stevenson, Richard D Riley   +17 more
doaj   +1 more source

Thiopurine S-methyltransferase – An important intersection of drug-drug interactions in thiopurine treatment

Biomedicine & Pharmacotherapy
Understanding the molecular mechanisms of medicines is crucial for developing novel drugs, for repurposing existing medicines, and for predicting toxicities. Thiopurine S-methyltransferase (TPMT) serves as an exemplary case in personalized medicine, as its activity is influenced by genetic variants, co-factors, substrates, and inhibitors, which lead to
Dunja Urbančič, Marko Jukič, Alenka Šmid, Stanislav Gobec, Janez Jazbec, Irena Mlinarič-Raščan   +5 more
openaire   +3 more sources

Association between the c.415C > T, c.52G > A, and 36_37insGGAGTC polymorphisms of NUDT 15 and thiopurine-induced leukopenia, thiopurine intolerance, and severe hair loss: an updated meta-analysis

Drug Design, Development and Therapy, 2019
Ruili Wang,1,2 Baogang Liu,2 Jiapeng Li,1 Jiamin Xu,1 Xiaoling Wang,1 Zhigang Zhao,2 Libo Zhao11Clinical Research Center, Beijing Children’s Hospital, National Center for Children’s Health, Capital Medical University, Beijing, People’s ...
Wang R, Liu B, Li J, Xu J, Wang X, Zhao Z, Zhao L   +6 more
doaj  

Pharmacogenetic studies of thiopurines : focus on thiopurine methyltransferase

, 2005
Pharmacogenetics represents the study ofvariability in drug response due to genetic variations. The thiopurines (6-mercaptopurine, 6-thioguanine and azathioprine) are prodrugs which require metabolic transformation to exert effect. Thiopurines are used in inflammatory bowel disease, as maintenance treatment of childhood acute lymphoblastic leukaemia ...
openaire   +1 more source

Thiopurine Methyltransferase Activity and Thiopurine Metabolites in Inflammatory Bowel Disease [PDF]

Crohn's & Colitis 360, 2020
openaire   +2 more sources

Clinical significance of thiopurine S-methyltransferase gene polymorphisms

, 2007
Thiopurine methyltransferase (TPMT) is an important enzyme that catalyzes the S-methylation of a series of thiopurine drugs, including 6-mercaptopurine (6-MP), thioguanine and azathiopurine (AZA), to generate inactive methylated metabolites.
Balram Chowbay (110465), Shufeng Zhou (398572)   +1 more
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Thiopurine 약물치료를 받고 있는 한국의 염증성 장질환 환자들의 Thiopurine Methyltransferase와 Inosine Triphosphate Pyrophosphatase의 유전자형과 장기간 치료 반응과의 상관관계

, 2010
Dept. of Medicine/석사[한글] [영문]Background and Aims: There is a lack of research describing associations between thiopurine methyltransferase (TPMT)/inosine triphosphate pyrophosphatase (ITPA) genotypes or phenotypes and long-term clinical outcomes after ...
정윤숙
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