Results 91 to 100 of about 11,830 (209)

Efficacy, Safety, and Pharmacokinetics of Upadacitinib Among Patients in East Asia With Moderately to Severely Active Ulcerative Colitis: A Post Hoc Subanalysis of Randomized Phase 3 Studies

Journal of Gastroenterology and Hepatology, Volume 41, Issue 9, Page 2709-2720, September 2026.
ABSTRACT Background and Aim Upadacitinib, a selective Janus kinase 1 inhibitor, is approved to treat moderately to severely active ulcerative colitis (UC). This post hoc subanalysis evaluated the efficacy, safety, and pharmacokinetics of upadacitinib in patients in East Asia. Methods U‐ACHIEVE (UC1; NCT02819635) and U‐ACCOMPLISH (UC2; NCT03653026) were
Shu Chen Wei, Hiroshi Nakase, Byong Duk Ye, Kang Chao, Hsin‐Yun Wu, Jason Eccleston, Xuan Yao, Hannah Palac, Mohamed‐Eslam F. Mohamed, Ana Victoria Ponce‐Bobadilla, Smitha Suravaram, Elena Marced Barrachina, Tadakazu Hisamatsu, Xiang Gao   +13 more
wiley   +1 more source

Thiopurine Drugs Repositioned as Tyrosinase Inhibitors

, 2017
In this study, we repositioned thiopurine drugs used for the treatment of acute leukaemia as new tyrosinase inhibitors. Tyrosinase catalyses two distinct and successive oxidations in melanin biosynthesis: the conversions of tyrosine to ...
Joonhyuck Choi, You-Mie Lee, Jun-Goo Jee
core   +2 more sources

Induction Therapy With Oral Tacrolimus Provides Long‐Term Benefit in Thiopurine‐Naïve Refractory Ulcerative Colitis Patients Despite Low Serum Albumin Levels

JGH Open
Background and Aim Oral tacrolimus is an effective treatment for refractory ulcerative colitis (UC). However, tacrolimus is underutilized because of the difficulties in transitioning to subsequent maintenance therapy and concerns about adverse events ...
Shoko Igawa, Toshihiro Inokuchi, Sakiko Hiraoka, Junki Toyosawa, Yuki Aoyama, Yasushi Yamasaki, Hideaki Kinugasa, Masahiro Takahara, Hiroyuki Okada, Motoyuki Otsuka   +9 more
doaj   +1 more source

Navigating Diagnostic Uncertainty and Therapeutic Complexity in IgG4-Related Sclerosing Cholangitis: A Case Report

International Journal of Medical Students
Background IgG4-related sclerosing cholangitis (IgG4-SC) is a fibroinflammatory condition that frequently mimics pancreatobiliary malignancies, contributing to its significant underdiagnosis.
Aleen Tumi, Hazeema Haq
doaj  

Update on conventional thiopurine management in IBD

, 2012
Conventional thiopurine therapy with azathioprine or 6-mercaptopurine is an important maintenance strategy in IBD. Unfortunately, many patients have to discontinue this therapy owing to adverse events or lack of efficacy.
Hoentjen, Frank, De Boer, Nanne K.H.
core  

Metabolic and genetic aspects of thiopurine metabolism [PDF]

, 2010
Side-effects from drugs often have a genetic background. The described PhD research focuses on the causes of side-effects from certain anti-inflammatory drugs, the thiopurines. These are often used to treat (auto) immune diseases.
Bakker, J.A.
core   +4 more sources

Thiopurines Induce Oxidative Stress in T-Lymphocytes: A Proteomic Approach

Mediators of Inflammation, 2015
Thiopurines are extensively used immunosuppressants for the treatment of inflammatory bowel disease (IBD). The polymorphism of thiopurine S-methyltransferase (TPMT) influences thiopurine metabolism and therapy outcome. We used a TPMT knockdown (kd) model
Misbah Misdaq, Sonia Ziegler, Nicolas von Ahsen, Michael Oellerich, Abdul R. Asif   +4 more
doaj   +1 more source

The clinical impact of thiopurine methyltransferase polymorphisms on thiopurine treatment

Acute lymphoblastic leukaemia (ALL) is the most common malignancy of childhood. Although current treatment results in long term survival in over 70% of cases there is evidence that as many as 50% could have been cured using a less complex regimen with a ...
Coulthard SA, Matheson EC, Hogarth LA, Hall AG   +3 more
core   +5 more sources

Allopurinol in combination with thiopurine induces mucosal healing and improves clinical and metabolic outcomes in IBD

Therapeutic Advances in Gastroenterology, 2017
Background: Thiopurines, azathioprine (AZA) and 6-mercaptopurine (6-MP) are common maintenance medications for inflammatory bowel disease (IBD).
Brigitte Moreau, Pierre Clement, Yves Theoret, Ernest G. Seidman   +3 more
doaj   +1 more source

NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity

, 2016
Widely used as anticancer and immunosuppressive agents, thiopurines have narrow therapeutic indices owing to frequent toxicities, partly explained by TPMT genetic polymorphisms.
Kihira, Kentaro, Xujie Zhao, Takaya Moriyama, Edwynn Kean-Hui Chiew, Relling, Mary V, Manabe, Atsushi, Hofmann, Ute, William E Evans, Ute Hofmann, Keito Hoshitsuki, Yang, Jun J, Hiroki Hori, Lin, Ting-Nien, Deepa Bhojwani, Katsuyoshi Koh, Koh, Katsuyoshi, Najera, Cesar Rolando, Perez-Andreu, Virginia, Kato, Motohiro, Schmiegelow, K., Klussmann, Federico Antillon, Tomoya Isobe, Kjeld Schmiegelow, Yan Lu, Wenjian Yang, Komada, Yoshihiro, Shirley Kow-Yin Kham, Yoshihiro Komada, Zhiwei Chen, Inaba, Hiroto, Isobe, Tomoya, Robert McCorkle, Lu, Yan, Hori, Hiroki, Virginia Perez-Andreu, Kham, Shirley Kow-Yin, McCorkle, Robert, Chen, Zhiwei, Ting-Nien Lin, Hoshitsuki, Keito, Moriyama, Takaya, Allen E J Yeoh, Cynthia Jeffries, Jacob Nersting, Nishii, Rina, Zhao, Xujie, Bhojwani, Deepa, Chiew, Edwynn Kean-Hui, Atsushi Manabe, Schwab, Matthias, Yeoh, Allen E J, Yang, Wenjian, Mary V Relling, Motohiro Kato, Rina Nishii, Hiroto Inaba, Matthias Schwab, Jun J Yang, Federico Antillon Klussmann, Nersting, Jacob, Ching-Hon Pui, Pui, Ching-Hon, Evans, William E, Cesar Rolando Najera, Lie Li, Li, Lie, Jeffries, Cynthia, Kentaro Kihira   +67 more
core   +1 more source