Results 71 to 80 of about 11,830 (209)

Operationalizing Precision Medicine in Drug Development: Predictive Biomarkers, Companion Diagnostics, and Regulatory Pathways

Clinical Pharmacology &Therapeutics, Volume 120, Issue 4, Page 914-929, October 2026.
Precision medicine offers the opportunity to improve the benefit–risk profile of new therapies by prospectively identifying patients most likely to respond or least likely to experience harm; however, its systematic integration into drug development remains inconsistent outside oncology.
Ingrid Holst‐Laubjerg, José M.A. Moreira   +1 more
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, Volume 16, Issue 9, Page 1825-1839, September 2026.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Thiopurine therapies: Problems, complexities and progress with monitoring thioguanine nucleotides

, 2005
Metabolism of thiopurine drugs-azathioprine, 6-mercaptopurine, and 6-thioguanine-has provided a powerful pharmacogenetic model incorporating polymorphism of the enzyme thiopurine methyltransferase (TPMT) and the primary active metabolite, thioguanine ...
Duley, J. A., Florin, T. H., Duley, John A., Florin, Timothy H. J.   +3 more
core   +1 more source

Treatment-related mutagenic processes in acute lymphoblastic leukemia

Haematologica
Karyotyping, SNP arrays, fluorescence in situ hybridisation and next generation sequencing techniques have greatly improved our understanding of the genetic drivers of acute lymphoblastic leukemia (ALL).
Cédric G. van der Ham, Frank N. van Leeuwen, Roland P. Kuiper   +2 more
doaj   +1 more source

Single‐Incision Laparoscopy‐First Strategy in Crohn's Disease: Risk Factors for Conversion and Surgical Outcomes

Annals of Gastroenterological Surgery, Volume 10, Issue 5, Page 1602-1611, September 2026.
In this retrospective study of 289 patients with Crohn's disease undergoing a single‐incision laparoscopy‐first (SILS‐first) strategy, conversion to open surgery was required in only 11.8% of cases. Fistula formation, colon resection, and smoking history were identified as independent risk factors for conversion, while postoperative complications and ...
Yuki Horio, Motoi Uchino, Yusuke Tomoo, Kentaro Nagano, Kurando Kusunoki, Ryuichi Kuwahara, Kei Kimura, Kozo Kataoka, Masataka Ikeda, Hiroki Ikeuchi   +9 more
wiley   +1 more source

Impact of NUDT15 polymorphisms on thiopurines-induced myelotoxicity and thiopurines tolerance dose

Oncotarget, 2017
Thiopurines are widely used as anticancer and immunosuppressive agents. However, life-threatening myelotoxicity has been noticed and largely explained by genetic variations, including NUDT15 polymorphisms (e.g., rs116855232). In this study, we conduct a meta-analysis to investigate the impact of rs116855232 on thiopurines-induced myelotoxicity ...
Yin, Dandan, Xia, Xuyang, Zhang, Junlong, Zhang, Shouyue, Liao, Fei, Zhang, Ge, Zhang, Yan, Hou, Qianqian, Yang, Xue, Wang, Hong, Ma, Zhigui, Wang, Heyao, Zhu, Yiping, Zhang, Wei, Wang, Yuelan, Liu, Bo, Wang, Lanlan, Xu, Heng, Shu, Yang   +18 more
openaire   +3 more sources

Differences in the risk of clinical failure between thiopurine and methotrexate in bio-naïve patients with Crohn’s disease: a Korean nationwide population-based study

Therapeutic Advances in Gastroenterology
Background: Although immunomodulators are widely prescribed in patients with Crohn’s disease (CD), it is unclear whether there is a difference in treatment outcomes between thiopurines and methotrexate (MTX).
Yu Kyung Jun, Eunjeong Ji, Hye Ran Yang, Yonghoon Choi, Cheol Min Shin, Young Soo Park, Nayoung Kim, Dong Ho Lee, Hyuk Yoon   +8 more
doaj   +1 more source

A Rapid and Reliable Absorbance Assay to Identify Drug–Drug Interactions with Thiopurine Drugs

Metabolites
Background: Thiopurine methyltransferase (TPMT) plays a crucial role in the detoxification of thiopurine drugs, including the antimetabolites azathioprine and 6-mercaptopurine (6-MP) used to treat autoimmune diseases and various cancers.
Drake A. Russell, Carson Stafford, Rheem A. Totah   +2 more
doaj   +1 more source

Population Pharmacokinetics and Dose De‐Escalation Regimens of Subcutaneous Vedolizumab in Inflammatory Bowel Disease

JCC Plus, Volume 1, Issue 5, September 2026.
ABSTRACT Background Vedolizumab is a therapeutic antibody approved for the treatment of Crohn's disease and ulcerative colitis. The population pharmacokinetics (popPK) of intravenous (IV) administered vedolizumab have been described, but remain to be defined for subcutaneous (SC) administration.
S. I. Anjie, N. Vreman, K. B. Gecse, M. Löwenberg, G. R. D'Haens, R. A. A. Mathôt   +5 more
wiley   +1 more source

Hair loss in pediatric inflammatory bowel disease: Clinical recognition and implications for care

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Angela Anaeme, Liza Siegel, Meryl Perlman   +2 more
wiley   +1 more source