Results 71 to 80 of about 19,377 (264)

Thiopurine methyltransferase predicts the extent of cytotoxicty and DNA damage in astroglial cells after thioguanine exposure. [PDF]

PLoS ONE, 2011
Thiopurine methyltransferase (Tpmt) is the primary enzyme responsible for deactivating thiopurine drugs. Thiopurine drugs (i.e., thioguanine [TG], mercaptopurine, azathioprine) are commonly used for the treatment of cancer, organ transplant, and ...
Amira Hosni-Ahmed, Joseph D Barnes, Jim Wan, Terreia S Jones   +3 more
doaj   +1 more source

LC–MS/MS Method for Measurement of Thiopurine Nucleotides (TN) in Erythrocytes and Association of TN Concentrations With TPMT Enzyme Activity

Frontiers in Pharmacology, 2022
Monitoring concentrations of thiopurine metabolites is used clinically to prevent adverse effects in patients on thiopurine drug therapy. We developed a LC–MS/MS method for the quantification of 6-thioguanine (6-TG) and 6-methylmercaptopurine (6-MMP) in ...
Amol O. Bajaj, Mark M. Kushnir, Mark M. Kushnir, Erik Kish-Trier, Rachel N. Law, Lauren M. Zuromski, Alejandro R. Molinelli, Gwendolyn A. McMillin, Gwendolyn A. McMillin, Kamisha L. Johnson-Davis, Kamisha L. Johnson-Davis   +10 more
doaj   +1 more source

Inequities in inflammatory bowel disease care: a Tasmanian case study with proposed solutions

Internal Medicine Journal, EarlyView.
Abstract There is well‐recognised inequity of care for people treated with inflammatory bowel disease (IBD) between metropolitan and regional areas. We aim to describe these barriers to care using Tasmania as a case example and to suggest solutions for addressing these barriers that can be used in Tasmania and beyond.
Alexander T Elford, Alyssa Pettersen, Emily Woods, Linda Boxhall, Zachiary Cooke, Anna Prebble, Jennifer Shoobridge, Jarrad Wilson, Scott Fanning   +8 more
wiley   +1 more source

Direct evidence of singlet molecular oxygen [O2 (1Δg)] production from UVA excited 6‐thioguanine

Photochemistry and Photobiology, EarlyView.
6‐Thioguanine (6‐TGua) is incorporated into DNA as a purine analogue, inhibiting cell replication. Patients treated with 6‐TGua are more prone to developing skin cancer due to the photoexcitation of 6‐TGua by UVA radiation (as illustrated in the Jablonski diagram). Upon exposure to UVA, the excited 6‐TGua generates 1O2.
André L. Lopes, Fernanda M. Prado, Helena C. Junqueira, Marisa H. G. Medeiros, Graziella E Ronsein, Jean Cadet, Paolo Di Mascio   +6 more
wiley   +1 more source

6-methylmercaptopurine-induced leukocytopenia during thiopurine therapy in inflammatory bowel disease patients [PDF]

, 2017
Background and Aim: Thiopurines have a favorable benefit–risk ratio in the treatment of inflammatory bowel disease. A feared adverse event of thiopurine therapy is myelotoxicity, mostly occurring due to toxic concentrations of the pharmacologically ...
Bodegraven, A.A. (Ad) van, Boer, K.H.N. (Nanne) de, Bouma, G. (Gerd), Derijks, L.J.J., Kreijne, J.E. (Joany), Meijer, B. (Berrie), Mulder, C.J.J. (Chris), van Moorsel, S.A.W. (Sofia A W), Wong, D.R. (Dennis R), Woude, C.J. (Janneke) van der   +9 more
core   +3 more sources

Growth in Paediatric Inflammatory Bowel Disease

JCC Plus, Volume 1, Issue 3, May 2026.
ABSTRACT Impaired linear growth is a common, clinically meaningful complication of paediatric inflammatory bowel disease (IBD), particularly Crohn's disease, arising from the combination of chronic intestinal inflammation, undernutrition, dysfunction of the growth hormone–insulin‐like growth factor‐1 axis, and iatrogenic effects such as glucocorticoid ...
Firas Rinawi, Séamus Hussey, Eileen Crowley, Dror S. Shouval, Iva Hojsak   +4 more
wiley   +1 more source

Loss of Nudt15 thiopurine detoxification increases direct DNA damage in hematopoietic stem cells

Scientific Reports, 2023
Thiopurines, such as 6-mercaptopurine (6-MP), are widely used as cytotoxic agents and immunosuppressants for leukemia and autoimmune or inflammatory diseases.
Noriaki Yamashita, Masahiro Kawahara, Takayuki Imai, Goichi Tatsumi, Ai Asai-Nishishita, Akira Andoh   +5 more
doaj   +1 more source

Systematic Review: The Impact of Geographic Location and Socioeconomic Status on Healthcare Utilisation and Clinical Outcomes in Patients With Inflammatory Bowel Disease (IBD) in the Developed World

JCC Plus, Volume 1, Issue 3, May 2026.
ABSTRACT Background Inflammatory bowel diseases (IBD) are a group of chronic inflammatory conditions affecting the gastrointestinal tract, which requires life‐long management. Healthcare inequalities in IBD are a key factor influencing disease outcomes. Aim This review aimed to describe the impact of geographical location (urban vs.
George Tambakis, Lei Lin, Rina Kumar, Jennifer Phillips, Anthony Croft, Graham Radford‐Smith, Gareth J. Walker   +6 more
wiley   +1 more source

Pharmacogenetics of thiopurine therapy: from thiopurine S-methyltransferase to S-adenosylmethionine [PDF]

BMC Pharmacology, 2009
Background The efficiency and safety of the thiopurine therapy rely on the concentration of patient’s cytotoxic thioguanine nucleotides (TGN), which in turn depend on the deactivation of thiopurine drugs by thiopurine S-methyltransferase (TPMT). The activity of TPMT largely depends on the presence of genetic polymorphisms. Determination of mutations in
Mlinarič-Raščan, Irena, Milek, Miha, Karas-Kuželički, Nataša   +2 more
openaire   +1 more source

Differences in the risk of clinical failure between thiopurine and methotrexate in bio-naïve patients with Crohn’s disease: a Korean nationwide population-based study

Therapeutic Advances in Gastroenterology
Background: Although immunomodulators are widely prescribed in patients with Crohn’s disease (CD), it is unclear whether there is a difference in treatment outcomes between thiopurines and methotrexate (MTX).
Yu Kyung Jun, Eunjeong Ji, Hye Ran Yang, Yonghoon Choi, Cheol Min Shin, Young Soo Park, Nayoung Kim, Dong Ho Lee, Hyuk Yoon   +8 more
doaj   +1 more source