Results 81 to 90 of about 11,830 (209)

Shifts in Mucosa‐Associated Microbiota Reflect Inflammation Gradient in Postoperative Crohn's Disease

JCC Plus, Volume 1, Issue 5, September 2026.
ABSTRACT Emerging evidence suggests that mucosa‐associated microbiota play an important role in postoperative Crohn's disease recurrence after ileocecal resection, with bacterial and fungal communities shifting across disease trajectory. This Y‐ECCO literature review discusses these changes across the Rutgeerts inflammatory spectrum, supporting the ...
Maya Fischman
wiley   +1 more source

Pharmacogenetics of thiopurine drugs [PDF]

, 2015
Tiopurinski lijekovi azatioprin (AZA), 6-merkaptopurin (6-MP) i 6-tiogvanin (6-TG) primjenjuju se za liječenje malignih bolesti, reumatskih bolesti, dermatoloških stanja, upalnih bolesti crijeva i nekih poremećaja imunološkog sustava.
Jelčić, Ana-Marija
core   +1 more source

Successful allo‐hematopoietic stem cell transplantation using washed hematopoietic stem cells in a pediatric patient complicated by acute myeloid leukemia and severe anaphylaxis to blood product

Pediatric Investigation, EarlyView.
Jieyu Tian, Guanghua Zhu, Maoquan Qin, Chenguang Jia, Shuxuan Ma, Bin Wang, Yanhui Luo   +6 more
wiley   +1 more source

Comparative Effectiveness Analysis of Phase 3 Clinical Trials in Moderately to Severely Active Inflammatory Bowel Disease Reveals Increased Harm From Placebo and Challenges Equipoise

JCC Plus, Volume 1, Issue 5, September 2026.
Across 47 Phase 3 trials in Crohn's disease and ulcerative colitis, placebo exposure was associated with measurable harm. Disease exacerbation events showed the greatest excess risk, with one additional exacerbation occurring for every 8–13 patients assigned to placebo rather than active therapy.
Joëlle St‐Pierre, Zachary D. Fine, Evan N. Fear, Jeremy A. Klein, Natalie K. Choi, David T. Rubin   +5 more
wiley   +1 more source

A practical guide to thiopurine prescribing and monitoring in IBD

, 2018
Thiopurines are often the mainstay of treatment for many patients with inflammatory bowel disease. As such, a general understanding of the evidence behind their use and of their metabolism is extremely useful in clinical practice.
Warner, Ben, Irving, Peter, Arenas-HernandeZ, Monica, Marinaki, Anthony, Sanderson, Jeremy, Johnston, Emma   +5 more
core   +1 more source

Efficacy of Interleukin‐12/23 and Interleukin‐23 Inhibitors for Moderately to Severely Active Crohn's Disease in Advanced Treatment Failure Populations: Systematic Review and Network Meta‐Analysis

JCC Plus, Volume 1, Issue 5, September 2026.
ABSTRACT Background and Aims Earlier trials of advanced treatments indicated for moderately to severely active Crohn's disease used predominantly re‐randomized induction responder designs, whereas newer treatments were evaluated using treat‐through designs.
Christopher Ma, Marla Dubinsky, Gil Y. Melmed, Namita Joshi, Jenny Griffith, Fernando Aponte, Brooke Kim, Eric B. Collins, Kristen Westerhoff, Remo Panaccione   +9 more
wiley   +1 more source

How Long Should We Taper Corticosteroids in Ulcerative Colitis? Insights From a Randomised Controlled Trial

JCC Plus, Volume 1, Issue 5, September 2026.
ABSTRACT Despite the widespread adoption of steroid‐sparing strategies, corticosteroids remain a cornerstone of induction therapy for moderate‐to‐severe ulcerative colitis (UC), yet the optimal tapering strategy remains poorly defined. This Y‐ECCO literature review summarises the randomised controlled trial by Kumar et al., which investigated the ...
Laura Gianolio
wiley   +1 more source

Clinical trial: Combination allopurinol-thiopurine versus standard thiopurine in patients with IBD escalating to immunomodulators (the DECIDER study)

BACKGROUND: Thiopurines are established treatments for inflammatory bowel disease (IBD), yet concerns remain regarding their safety. AIM: To evaluate the use of thiopurine-allopurinol combination therapy compared to standard thiopurine therapy in IBD ...
van Langenberg, DR, de Cruz, P, Vasudevan, A, Gibson, PR, Kashkooli, S, Friedman, AB, Garg, M, Con, D, Sparrow, MP   +8 more
core   +1 more source

Transporter-Mediated Protection against Thiopurine-Induced Hematopoietic Toxicity

, 2008
Thiopurines are effective immunosuppressants and anticancer agents, but intracellular accumulation of their active metabolites (6-thioguanine nucleotides, 6-TGN) causes dose-limiting hematopoietic toxicity.
Richard B. Kim, Poonkuzhali, Balasubramanian, Erin Schuetz, Nachagari, Deepa, Mary Relling, Mark Leslie, Deepa Nachagari, Weinan Du, Schuetz, Erin, Schwab, Matthias, Boyd, Kelli, Partha Krishnamurthy, John D. Schuetz, William Evans, Schuetz, John D., Morgan, Jessica, Du, Weinan, Nakauchi, Hiromitsu, Krishnamurthy, Partha, Jessica Morgan, Takenaka, Kazumasa, Matthias Schwab, Marzolini, Catia, Relling, Mary, Catia Marzolini, Evans, William, Leslie, Mark, Kim, Richard B., Cheok, Meyling, Hiromitsu Nakauchi, Meyling Cheok, Kelli Boyd, Kazumasa Takenaka, Balasubramanian Poonkuzhali   +33 more
core   +1 more source

Review Article: The Impact of the Gut Microbiome on Ulcerative Colitis Pharmacotherapy

Alimentary Pharmacology &Therapeutics, Volume 64, Issue 6, Page 729-747, September 2026.
The gut microbiome modulates ulcerative colitis pharmacotherapy through microbial drug metabolism, immune regulation and altered drug bioavailability. Microbial composition influences response to aminosalicylates, corticosteroids, immunomodulators, biologics and small molecules, while microbiome‐targeted therapies show emerging promise.
Kate Collins, Srinivas Kamath, Rachel H. Davis, Samuel P. Costello, Robert V. Bryant, Alice S. Day, Paul Joyce   +6 more
wiley   +1 more source