Results 81 to 90 of about 19,377 (264)
TCD4pos lymphocytosis in rheumatoid and psoriatic arthritis patients following TNFα blocking agents [PDF]
, 2017 BACKGROUND: Lymphocyte expansion and true lymphocytosis are commonly observed in the everyday clinical practice. The meaning of such phenomenon is often poorly understood so that discrimination between benign and malignant lymphocytosis remains ...
Amodeo, Rachele +11 more
core +1 more source
Clinical and Translational Science, Volume 19, Issue 5, May 2026.ABSTRACT Biomarker testing plays a critical role in precision oncology by guiding targeted therapy selection. In Australia, public reimbursement for somatic tumor biomarker tests has expanded over the past decade, yet national data on utilization patterns, equity of access, and public expenditure remain limited. We identified all cancer biomarker tests
Leping Kong, Christine Y. Lu
wiley +1 more source
بررسی شيوع آللهای شناختهشده ژن آنزيم تيوپورين متيل تراسفراز (TPMT) در مراجعه کنندگان به درمانگاه بيمارستان شريعتی تهران [PDF]
, 2009 زمينه: بيماران با سطوح پائين و يا متوسط فعاليت آنزيم تيوپورين متيل تراسفراز (TPMT) در معرض افزايش خطر ابتلا به سرکوب سلولهای رده خون ساز مغز استخوان پس از مصرف داروهای تيويورينی خواهند بود.
آزادی, مهدی +4 more
core
Liver dysfunction in patients with IBD under immunosuppressive treatment: do we need to fear? [PDF]
, 2010 International ...
Beaugerie, Laurent, Gerbes, Alexander L.
core +3 more sources
Obesity Reviews, Volume 27, Issue 5, May 2026.ABSTRACT Inflammatory bowel disease is a chronic inflammatory disorder affecting the gastrointestinal tract. It mainly comprises of Crohn's disease and ulcerative colitis. Its global prevalence has risen simultaneously with overweight and obesity among children and young people over the last decades.
Razan Algarni +2 more
wiley +1 more source
Pediatric Blood &Cancer, Volume 73, Issue 4, April 2026.ABSTRACT Introduction Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer. The pro‐drug 6‐mercaptopurine (6‐MP), essential during maintenance, is converted into active 6‐thioguanine (6‐TGN) and toxic 6‐methylmercaptopurine (6‐MMP) metabolites, resulting in marked variability in efficacy and toxicity.
Anne Ravix +5 more
wiley +1 more source
A Rapid and Reliable Absorbance Assay to Identify Drug–Drug Interactions with Thiopurine Drugs
MetabolitesBackground: Thiopurine methyltransferase (TPMT) plays a crucial role in the detoxification of thiopurine drugs, including the antimetabolites azathioprine and 6-mercaptopurine (6-MP) used to treat autoimmune diseases and various cancers.
Drake A. Russell +2 more
doaj +1 more source
Carcinogenic Medications: A Review of Specific Agents and Molecular Mechanisms of Carcinogenesis
Cancer Reports, Volume 9, Issue 4, April 2026.ABSTRACT Background Pharmacovigilance has revealed an alarming correlation between certain medications and a higher risk of cancer. In this narrative review, included research from 2020 to 2025, along with a few seminal older studies, so that it provides a clear picture of which drugs actually set off cancer and mechanisms involved at the molecular ...
Desta Seyoum Tadesse +5 more
wiley +1 more source
The Turkish Journal of GastroenterologyBackground/Aims: The thiopurine drugs—azathioprine and mercaptopurine—are purine antimetabolites used for the treatment of autoimmune hepatitis. These drugs undergo metabolism through genetically determined pathways, which influences their effectiveness ...
Woroud Yassin +3 more
doaj +1 more source
Traditional Chinese medicine combination therapy for patients with steroid-dependent ulcerative colitis: study protocol for a randomized controlled trial [PDF]
, 2017 SPIRIT 2013 Checklist: recommended items to address in a clinical trial protocol and related documents.
Hong Shen +6 more
core +3 more sources