HLA-DQB1*03:01 and HLA-DQA1*05:05 as key genetic determinants of infliximab response and immunogenicity in Japanese patients with inflammatory bowel disease. [PDF]
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Pharmacogenetic Analysis of TPMT and NUDT15 in a European Pediatric Cohort with IBD and Autoimmune Diseases: Frequency Data and Clinical Relevance. [PDF]
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Practical guide to implementing pre-emptive pharmacogenetic screening in routine pediatric oncology care. [PDF]
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Vedolizumab in inflammatory bowel disease: pharmacokinetics and the role of immunomodulator co-therapy. [PDF]
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A guide to healthcare maintenance for the patient with inflammatory bowel disease. [PDF]
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[Pharmacogenetic study of thiopurine S-methyltransferase (TPMT) and thiopurine toxicity].
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The Clinical Impact of Thiopurine Methyltransferase Polymorphisms on Thiopurine Treatment
Nucleosides, Nucleotides and Nucleic Acids, 2004Acute lymphoblastic leukaemia (ALL) is the most common malignancy of childhood. Although current treatment results in long term survival in over 70% of cases there is evidence that as many as 50% could have been cured using a less complex regimen with a lower incidence of long term side effects.
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Thiopurines are a class of immunosuppressant and antineoplastic drugs developed by Gertrude Elion and George Hitchings and patented in 1953 for use to treat leukaemia, then used to prevent transplant rejection (Marx, 2005).
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