Results 171 to 180 of about 11,830 (209)

Reducing risk in thiopurine therapy

Xenobiotica, 2019
The thiopurine drugs azathioprine and mercaptopurine are effective in the treatment of disorders of immune regulation and acute lymphoblastic leukaemia. Although developed in the 1950s, thiopurines remained relevant in the anti-tumour necrosis factor biologic era, finding widespread use as a co-immunomodulator.
Anthony M, Marinaki, Monica, Arenas-Hernandez   +1 more
openaire   +2 more sources

Clinical pharmacology and pharmacogenetics of thiopurines

European Journal of Clinical Pharmacology, 2008
The thiopurine drugs-azathioprine (AZA), 6-mercaptopurine (6-MP), and thioguanine-are widely used to treat malignancies, rheumatic diseases, dermatologic conditions, inflammatory bowel disease, and solid organ transplant rejection. However, thiopurine drugs have a relatively narrow therapeutic index and are capable of causing life-threatening toxicity,
Srikumar, Sahasranaman, Danny, Howard, Sandip, Roy   +2 more
openaire   +2 more sources

On the malignant potential of thiopurine therapy

Blood, 2009
To the editor: With great interest we have read the paper by Schmiegelow and colleagues describing the increased risk of developing a second malignant neoplasm, especially acute myeloid leukemia and myelodysplastic syndromes, due to maintenance therapy with 6-mercaptopurine (6-MP) and ...
de Boer, N., van Asseldonk, D.P., van Bodegraven, A.A.   +2 more
openaire   +4 more sources

Thiopurine therapy

European Journal of Gastroenterology & Hepatology, 2003
The thiopurines azathioprine and 6-mercaptopurine are effective both for active disease and for maintaining remission in both Crohn's disease and ulcerative colitis. This review describes criteria for starting thiopurines (two or more courses of steroids in a calendar year, relapse as prednisolone is reduced below 15 mg/day, within 6 weeks of stopping ...
Dermot P B, McGovern, Simon P L, Travis
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Low-dose thiopurine with allopurinol co-therapy overcomes thiopurine intolerance and allows thiopurine continuation in inflammatory bowel disease

Digestive and Liver Disease, 2018
To assess the utility and tolerability of thiopurine-allopurinol co-therapy in inflammatory bowel disease (IBD) patients with intolerance to thiopurine monotherapy.A retrospective observational study assessed cases of thiopurine intolerance then switched to thiopurine allopurinol co-therapy between 2011 and 2015 at two centres.
Abhinav Vasudevan, Lauren Beswick, Antony B. Friedman, Alicia Moltzen, James Haridy, Ajay Raghunath, Miles Sparrow, Daniel van Langenberg   +7 more
openaire   +2 more sources

Methods for the Synthesis of 6‐Thiopurines

ChemInform, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
openaire   +1 more source

Pharmacogenetics of thiopurines

2008
The thiopurines (mercaptopurine, azathioprine and thioguanine) have been highly successful drugs, heralding the era of organ transplantation, providing maintenance therapy in the treatment of leukemias,1 and proving useful for treating chronic inflammatory and autoimmune conditions (see: Chapter 38).2,3 Overall, the therapeutic success rate for ...
Oancea, I., Duley, J. A.
openaire   +1 more source

Thiopurine pharmacogenetics: clinical and molecular studies of thiopurine methyltransferase.

Drug metabolism and disposition: the biological fate of chemicals, 2001
Thiopurine drugs are used to treat patients with neoplasia and autoimmune disease as well as transplant recipients. These agents are metabolized, in part, by S-methylation catalyzed by thiopurine methyltransferase (TPMT). The discovery nearly two decades ago that levels of TPMT activity in human tissues are controlled by a common genetic polymorphism ...
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Intrauterine exposure to thiopurines

Reproductive Toxicology, 2012
Jharap, B., Seinen, M.L., van Bodegraven, A.A., de Boer, K.H.N.   +3 more
openaire   +2 more sources

Thiopurine biology and pharmacology

Trends in Pharmacological Sciences, 1997
J, Aarbakke, G, Janka-Schaub, G B, Elion
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