Results 161 to 170 of about 11,830 (209)

The thiopurines: An update

Investigational New Drugs, 2005
The thiopurine drugs, 6-mercaptopurine (6-MP), 6-thioguanine (6-TG) are commonly used cytotoxic agents. A derivative of 6-MP, azathioprine, is commonly used as an immunosuppressant. A prominent route for the metabolism of these agents is mediated by the enzyme thiopurine methyltransferase (TPMT).
Sally, Coulthard, Linda, Hogarth
openaire   +2 more sources

The Future of Thiopurine Pharmacogenomics

Pharmacogenomics, 2012
Since their invention [1], thiopurines (azathioprine, 6-mercaptopurine [6MP], and 6-thioguanine [6TG]) have significantly advanced the treatment of acute lymphoblastic leukemia, organ transplantation, inflammatory bowel disease (IBD) and various autoimmune diseases.
Duley, John A., Somogyi, Andrew A., Martin, Jennifer H.   +2 more
openaire   +5 more sources

Thiopurine Methyltransferase and Thiopurine Metabolite Testing in Patients with Inflammatory Bowel Disease who are Taking Thiopurine Drugs

Pharmacogenomics, 2009
Thiopurine methyltransferase genotyping and thiopurine metabolite testing has been established as an adjunct to monitoring patients taking thiopurine drugs. This special report describes the clinical implications for this type of testing for patients with inflammatory bowel disease who are taking thiopurine drugs.
Peter George, Arun Gupta, Mithilesh Dronavalli   +2 more
exaly   +3 more sources

The Effect of Thiopurine Methyltransferase Expression on Sensitivity to Thiopurine Drugs

Molecular Pharmacology, 2002
Although the thiopurine drugs 6-mercaptopurine (6-MP) and 6-thioguanine (6-TG) are well established agents for the treatment of leukemia, controversies remain regarding their main mode of action. Previous evidence has suggested that although 6-TG exerts a cytotoxic effect through incorporation of 6-thioguanine nucleotides into newly synthesized DNA ...
Coulthard, S.A., Hogarth, L.A., Little, M.A., Matheson, E., Redfern, C.P.F., Minto, C.L.J., Hall, A.G.   +13 more
openaire   +3 more sources

Characterisation and utility of thiopurine methyltransferase and thiopurine metabolite measurements in autoimmune hepatitis

Journal of Hepatology, 2010
Corticosteroids alone or in conjunction with azathioprine (AZA) is the standard treatment in autoimmune hepatitis (AiH). Individual variations in thiopurine (TP) metabolism may affect both drug efficacy and toxicity. Our aim was to investigate the utility of thiopurine methyltransferase (TPMT) as well as thioguanine nucleotide (TGN) and ...
Hanne Prytz, Curt Peterson
exaly   +3 more sources

Individualization of Thiopurine Therapy: Thiopurine S -Methyltransferase and Beyond

Pharmacogenomics, 2009
The metabolism of a given drug depends, not solely on a particular enzyme, but rather on a complex metabolic network. Thiopurine S-methyltransferase (TPMT) catalyzes the methylation, and thus deactivation, of 6-mercaptopurine, a thiopurine used in the treatment of acute lymphoblastic leukemia.
Natasa, Karas-Kuzelicki, Irena, Mlinaric-Rascan   +1 more
openaire   +2 more sources

Pharmacogenetics of Thiopurine S-Methyltransferase and Thiopurine Therapy

Therapeutic Drug Monitoring, 2004
Most medications exhibit wide interpatient variability in their efficacy and toxicity. For many medications, these interindividual differences result in part from polymorphisms in genes encoding drug-metabolizing enzymes, drug transporters, and/or drug targets (eg, receptors, enzymes).
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Biology and Pharmacology of Thiopurines

Pediatric Hematology and Oncology, 1995
(1995). Biology and Pharmacology of Thiopurines. Pediatric Hematology and Oncology: Vol. 12, No. 5, pp. 511-519.
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Improved HPLC methodology for monitoring thiopurine metabolites in patients on thiopurine therapy

Clinical Biochemistry, 2004
Standardization of thiopurine metabolite testing is currently lacking. This paper presents in-depth methodological analysis and optimization of two currently available HPLC procedures (Lennard-Singleton [J. Chromatogr. 583 (1992) 83] and Dervieux-Boulieu [Clin. Chem.
Cristiana, Stefan, Warren, Walsh, Tibor, Banka, Khosrow, Adeli, Zulfikarali, Verjee   +4 more
openaire   +2 more sources

Role of Thiopurine Metabolite Testing and Thiopurine Methyltransferase Determination in Pediatric IBD

Journal of Pediatric Gastroenterology and Nutrition, 2013
ABSTRACTThiopurines have been used in inflammatory bowel disease (IBD) for >30 years, and measurements of both thiopurine methyltransferase (TPMT) and thiopurine (TP) metabolites, 6‐thioguanine nucleotides (6‐TGN) and 6‐methylmercaptopurine (6‐MMP), have been readily available.
Keith, Benkov, Ying, Lu, Ashish, Patel, Riad, Rahhal, Gary, Russell, Jonathan, Teitelbaum   +5 more
openaire   +2 more sources