Results 161 to 170 of about 16,205 (199)
[Pharmacogenetic study of thiopurine S-methyltransferase (TPMT) and thiopurine toxicity].
Revista espanola de enfermedades digestivas, 2003 H, Corominas +3 more
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Relationship Between Thiopurine S-Methyltransferase Genotype and Phenotype in Pediatric Acute Lymphoblastic Leukemia in Addis Ababa, Ethiopia. [PDF]
J Pediatr Pharmacol TherAli AM +6 more
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Late hepatotoxicity after treatment for childhood cancer. [PDF]
World J HepatolRoganovic J, Vidovic A, Dordevic A.
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British Journal of Hospital Medicine, 2013
Thiopurines are a class of immunosuppressant and antineoplastic drugs developed by Gertrude Elion and George Hitchings and patented in 1953 for use to treat leukaemia, then used to prevent transplant rejection (Marx, 2005).
Kl, de Wit, Be, White, D, Goldsmith
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Thiopurines are a class of immunosuppressant and antineoplastic drugs developed by Gertrude Elion and George Hitchings and patented in 1953 for use to treat leukaemia, then used to prevent transplant rejection (Marx, 2005).
Kl, de Wit, Be, White, D, Goldsmith
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Investigational New Drugs, 2005
The thiopurine drugs, 6-mercaptopurine (6-MP), 6-thioguanine (6-TG) are commonly used cytotoxic agents. A derivative of 6-MP, azathioprine, is commonly used as an immunosuppressant. A prominent route for the metabolism of these agents is mediated by the enzyme thiopurine methyltransferase (TPMT).
Sally, Coulthard, Linda, Hogarth
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The thiopurine drugs, 6-mercaptopurine (6-MP), 6-thioguanine (6-TG) are commonly used cytotoxic agents. A derivative of 6-MP, azathioprine, is commonly used as an immunosuppressant. A prominent route for the metabolism of these agents is mediated by the enzyme thiopurine methyltransferase (TPMT).
Sally, Coulthard, Linda, Hogarth
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The Clinical Impact of Thiopurine Methyltransferase Polymorphisms on Thiopurine Treatment
Nucleosides, Nucleotides and Nucleic Acids, 2004Acute lymphoblastic leukaemia (ALL) is the most common malignancy of childhood. Although current treatment results in long term survival in over 70% of cases there is evidence that as many as 50% could have been cured using a less complex regimen with a lower incidence of long term side effects.
S A, Coulthard +3 more
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Individualization of Thiopurine Therapy: Thiopurine S -Methyltransferase and Beyond
Pharmacogenomics, 2009The metabolism of a given drug depends, not solely on a particular enzyme, but rather on a complex metabolic network. Thiopurine S-methyltransferase (TPMT) catalyzes the methylation, and thus deactivation, of 6-mercaptopurine, a thiopurine used in the treatment of acute lymphoblastic leukemia.
Natasa, Karas-Kuzelicki +1 more
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