Results 31 to 40 of about 16,205 (199)

Change in hematologic indices over time in pediatric inflammatory bowel disease treated with azathioprine [PDF]

, 2010
Azathioprine leads to changes in mean corpuscular volume (MCV) and white blood cell (WBC) indices reflecting efficacy or toxicity. Understanding the interactions between bone marrow stem cells and azathioprine could highlight abnormal response patterns ...
A Timmer, AC Mackey, AG Fraser, Chris J. Taylor, CN Bernstein, CW Thomas Jr, David I. Campbell, DH Present, Dhandapani Ashok, I Tiede, J Glas, LJ Derijks, P Karran, S Al-Safi, Sally A. Connolly, Samantha J. Cordell, Sherman Soman, W Disanti, Y Masunaga   +18 more
core   +2 more sources

Clinical utility of thiopurine metabolite monitoring in inflammatory bowel disease and its impact on healthcare utilization in Singapore

JGH Open, 2022
Background and Aim Thiopurines are recommended for maintenance of steroid‐free remission (SFR) in inflammatory bowel disease (IBD). Thiopurine metabolite monitoring (MM) is increasingly used in the West but remains novel in Singapore, with limited ...
Jia Qi Yeo, Hua Heng McVin Cheen, Amanda Wong, Teong Guan Lim, Balram Chowbay, Wai Fook Leong, Chunyan Wang, Ennaliza Salazar, Webber Pak Wo Chan, San Choon Kong, Wan Chee Ong   +10 more
doaj   +1 more source

Severe Complication of Thiopurine Treatment in a Young Woman with Crohn’s Disease

European Journal of Case Reports in Internal Medicine, 2021
Case Description: TA 28-year old woman receiving thiopurine treatment for Crohn’s disease presented with a systemic primo cytomegalovirus (CMV) infection affecting the gut (colitis), liver (hepatitis), lungs (pneumonitis) and eyes (retinitis).
Michiel PJ Voet, TGA Calon, MMC Hendriks, RM Schreuder   +3 more
doaj   +1 more source

Thiopurine pharmacogenomics: association of SNPs with clinical response and functional validation of candidate genes [PDF]

, 2014
Aim: We investigated candidate genes associated with thiopurine metabolism and clinical response in childhood acute lymphoblastic leukemia. Materials & methods: We performed genome-wide SNP association studies of 6-thioguanine and 6-mercaptopurine ...
Batzler, A., Cartwright, C.S., Fridley, B.L., Jenkins, G., Lennard, L., Li, F., Livshits, A., Matimba, A., Scully, S., Wang, L., Weinshilboum, R.   +10 more
core   +1 more source

Thiopurines: Recent Topics and Their Role in the Treatment of Inflammatory Bowel Diseases

Frontiers in Pharmacology, 2021
Ulcerative colitis (UC) and Crohn's disease (CD) are chronic inflammatory bowel diseases (IBD) of unknown etiology, characterized by repeated relapse and remission. The efficacy of thiopurine in IBD was first reported in the late 1960s.
Keiichi Tominaga, Takeshi Sugaya, Takanao Tanaka, Mimari Kanazawa, Makoto Iijima, Atsushi Irisawa   +5 more
doaj   +1 more source

Azathioprine‐induced severe myelosuppression accompanied by massive hair loss and painful oral ulcer in an autoimmune hepatitis patient with NUDT15 minor variant: A case report

Clinical Case Reports, 2021
This report highlights azathioprine‐induced severe myelosuppression in the patient with NUDT15 minor variant. This case report is particularly instructive because several typical symptoms are the clues to this critical adverse drug reaction.
Yu Takeuchi, Hidenao Noritake, Moe Matsumoto, Masahiro Umemura, Maho Yamashita, Kensuke Kitsugi, Shingo Takatori, Kazuyoshi Ohta, Jun Ito, Shin Shimoyama, Akira Kaysuya, Chiaki Maruyama, Kensuke Fukuchi, Satoshi Dohtan, Hiroe Sakata, Kazuhito Kawata   +15 more
doaj   +1 more source

TPMT and NUDT15 testing for thiopurine therapy: A major tertiary hospital experience and lessons learned

Frontiers in Pharmacology, 2022
Variants in thiopurine methyltransferase (TPMT) and nudix hydrolase 15 (NUDT15) are associated with an accumulation of cytotoxic metabolites leading to increased risk of drug-related toxicity with standard doses of thiopurine drugs.
Liuh Ling Goh, Chia Wei Lim, Khai Pang Leong, Khai Pang Leong, Kiat Hoe Ong, Kiat Hoe Ong   +5 more
doaj   +1 more source

Personalized medicine : the impact on chemistry [PDF]

, 2010
An effective strategy for personalized medicine requires a major conceptual change in the development and application of therapeutics. In this article, we argue that further advances in this field should be made with reference to another conceptual shift,
Marsh, Andrew, Singer, Donald R. J., Taylor, Paul C., Watkins, John   +3 more
core   +1 more source

Optimizing thiopurine therapy in children with acute lymphoblastic leukemia: A promising “MINT” sequencing strategy and therapeutic “DNA-TG” monitoring

Frontiers in Pharmacology, 2022
Thiopurines, including thioguanine (TG), 6-mercaptopurine (6-MP), and azathioprine (AZA), are extensively used in clinical practice in children with acute lymphoblastic leukemia (ALL) and inflammatory bowel diseases.
Hong-Li Guo, Yue-Tao Zhao, Yue-Tao Zhao, Wei-Jun Wang, Wei-Jun Wang, Na Dong, Na Dong, Ya-Hui Hu, Yuan-Yuan Zhang, Feng Chen, Li Zhou, Tao Li   +11 more
doaj   +1 more source

Prevention of thiopurine-induced early leukopenia in a Korean pediatric patient with Crohn’s disease who turned out to possess homozygous mutations in R139C [PDF]

Yeungnam University Journal of Medicine, 2020
Homozygous mutations in NUDT15 R139C are known as the major factor associated with thiopurine-induced early leukopenia, particularly in Asian patients. Therefore, NUDT15 genotyping is currently recommended before thiopurine treatment to identify patients
Jaewoan Bae, Byung-Ho Choe, Ben Kang
doaj   +1 more source