Results 11 to 20 of about 11,830 (209)
Pharmacogenetics and Genomics, 2010 The thiopurine drugs are purine antimetabolites widely used in the treatment of acute lymphoblastic leukemia, autoimmune disorders (e.g. Crohn’s disease and rheumatoid arthritis) and of organ transplant recipients. As inactive prodrugs, 6-mercaptopurine (6-MP), 6-thioguanine (6-TG) and azathioprine require intracellular activation, catalyzed by ...
Gianluigi Zaza +11 more
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Association between thiopurine S-methyltransferase polymorphisms and thiopurine-induced adverse drug reactions in patients with inflammatory bowel disease: a meta-analysis. [PDF]
PLoS ONE, 2015 Thiopurine drugs are well established treatments in the management of inflammatory bowel disease (IBD), but their use is limited by significant adverse drug reactions (ADRs).
Yue-Ping Liu +8 more
doaj +2 more sources
Personalization of thiopurine therapy: Current recommendations and future perspectives [PDF]
Acta PharmaceuticaDespite great therapeutic advances in the field of biologics, small synthetic molecules such as thiopurines, including azathioprine, mercaptopurine, and thioguanine, remain an important therapeutic pillar in the treatment of inflammatory bowel disease ...
Urbančič Dunja +3 more
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The Turkish Journal of GastroenterologyBackground/Aims: The thiopurine drugs—azathioprine and mercaptopurine—are purine antimetabolites used for the treatment of autoimmune hepatitis. These drugs undergo metabolism through genetically determined pathways, which influences their effectiveness ...
Woroud Yassin +3 more
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Thiopurine Metabolism in the Era of Combotherapy [PDF]
Inflammatory Bowel Diseases, 2016 6-thioguanine nucleotides levels are associated with clinical remission in patients with inflammatory bowel disease (IBD) on thiopurine monotherapy. Recently, few studies investigated the interaction between thiopurine metabolism and anti-tumor necrosis factor therapy among patients with IBD on combotherapy.
Roblin, Xavier +2 more
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Pharmacogenomics and Personalized Medicine, 2017 Rachid Abaji,1 Maja Krajinovic2 1Department of Pharmacology, 2Departments of Pediatrics and Pharmacology, CHU Sainte-Justine Research Center, University of Montreal, Montreal, QC, Canada Abstract: The thiopurine S-methyltransferase (TPMT) gene encodes ...
Abaji R, Krajinovic M
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Nucleosides, Nucleotides and Nucleic Acids, 2006 The aim of this study was to follow, during standardized initiation of thiopurine treatment, thiopurine methyltransferase (TPMT) gene expression and enzyme activity and thiopurine metabolite concentrations, and to study the role of TPMT and ITPA 94C > A polymorphisms for the development of adverse drug reactions.
M, Lindqvist +6 more
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The NUDIX hydrolase NUDT5 regulates thiopurine metabolism and cytotoxicity
The Journal of Clinical InvestigationThiopurines are anticancer agents used for the treatment of leukemia and autoimmune diseases. These purine analogs are characterized by a narrow therapeutic index because of the risk of myelosuppression.
Maud Maillard +11 more
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Thiopurine methyltransferase phenotyping and genotyping in clinical practice preferred access arrangement [PDF]
, 2010 Thiopurine methyltransferase (TPMT) metabolises the widely prescribed thiopurine drugs. The activity of this enzyme varies between individuals and this can influence treatment success.
Graham, Valerie
core +7 more sources
The Thiopurine Tale: An Unexpected Journey [PDF]
Journal of Crohn's and Colitis, 2022 Abstract Exactly 70 years ago [1951] mercaptopurine was discovered by Gertrude Elion as a novel treatment option for acute leukaemia. A total of three thiopurines (also thioguanine [1950] and azathioprine [1957]) were developed over time.
Femke Crouwel +2 more
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