Results 21 to 30 of about 19,377 (264)
Journal of Pharmacological Sciences, 2023 The usefulness of NUDT15 genotyping as a pharmacogenomic test for thiopurine has been established. The first such test developed to date, NUDT15 genotyping was approved for reimbursement in Japan in February 2019 for all indicated patients.
Yoichi Kakuta +8 more
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Long-term efficacy and tolerability of dose-adjusted thiopurine treatment in maintaining remission in inflammatory bowel disease patients with heterozygosity [PDF]
Intestinal Research, 2022 Background/Aims Thiopurines are key drugs for inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn’s disease (CD). Recently, NUDT15 polymorphism (R139C, c.415C > T) has been shown to be associated with thiopurine-induced adverse ...
Takato Maeda +11 more
doaj +1 more source
Life Science Alliance, 2023 This study evaluates the role of PACSIN2 in autophagy modulation and its impact on mercaptopurine cytotoxicity in lymphoid and intestinal models.
Giulia Zudeh +10 more
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Apoptosome activation, an important molecular instigator in 6-mercaptopurine induced Leydig cell death. [PDF]
, 2015 Leydig cells are crucial to the production of testosterone in males. It is unknown if the cancer chemotherapeutic drug, 6-mercaptopurine (6 MP), produces Leydig cell failure among adult survivors of childhood acute lymphoblastic leukemia. Moreover, it is
Bao, Ju +11 more
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The Thiopurine Tale: An Unexpected Journey [PDF]
Journal of Crohn's and Colitis, 2022 Abstract Exactly 70 years ago [1951] mercaptopurine was discovered by Gertrude Elion as a novel treatment option for acute leukaemia. A total of three thiopurines (also thioguanine [1950] and azathioprine [1957]) were developed over time.
Femke Crouwel +2 more
openaire +3 more sources
Frontiers in Pharmacology, 2018 Azathioprine and 6-mercaptopurine, often referred to as thiopurine compounds, are commonly used in the management of inflammatory bowel disease. However, patients receiving these drugs are prone to developing adverse drug reactions or therapeutic ...
Sheng Zhang Lim, Eng Wee Chua
doaj +1 more source
Personalized medicine : the impact on chemistry [PDF]
, 2010 An effective strategy for personalized medicine requires a major conceptual change in the development and application of therapeutics. In this article, we argue that further advances in this field should be made with reference to another conceptual shift,
Marsh, Andrew +3 more
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Clinical application of high throughput molecular screening techniques for pharmacogenomics. [PDF]
, 2011 Genetic analysis is one of the fastest-growing areas of clinical diagnostics. Fortunately, as our knowledge of clinically relevant genetic variants rapidly expands, so does our ability to detect these variants in patient samples.
Schrijver, Iris, Wiita, Arun P
core +1 more source
Effects of PRPS1 I72 mutations on drug resistance in acute lymphoblastic leukemia and its mechanisms
Shanghai Jiaotong Daxue xuebao. Yixue ban, 2023 Objective·To study whether mutations at the I72 site of phosphoribosyl pyrophosphate synthetase 1 (PRPS1) can induce resistance in acute lymphoblastic leukemia (ALL) cells to thiopurine chemotherapy drugs 6-mercaptopurine (6-MP) and 6-thioguanine (6-TG),
CUI Zhiyan +4 more
doaj +1 more source
PLoS ONE, 2017 The association between the 6-thioguanine nucleotide (6-TGN) level and clinical remission in Crohn's disease (CD) remains controversial. Thiopurine-induced leukopenia is a life-threatening complication of CD in Asians that was recently shown to strongly ...
Ji Hyeon Lee +8 more
doaj +1 more source