Results 31 to 40 of about 11,830 (209)

PACSIN2 as a modulator of autophagy and mercaptopurine cytotoxicity: mechanisms in lymphoid and intestinal cells

Life Science Alliance, 2023
This study evaluates the role of PACSIN2 in autophagy modulation and its impact on mercaptopurine cytotoxicity in lymphoid and intestinal models.
Giulia Zudeh, Raffaella Franca, Marianna Lucafò, Erik J Bonten, Matteo Bramuzzo, Riccardo Sgarra, Cristina Lagatolla, Martina Franzin, William E Evans, Giuliana Decorti, Gabriele Stocco   +10 more
doaj   +1 more source

Clinical application of thiopurine pharmacogenomics in pediatrics

, 2020
Background: Thiopurine drugs are used for the treatment of pediatric diseases. Inter-individual differences in the metabolism of these drugs greatly influence the risk of thiopurine induced toxicity and therapy failure.
Kotur N., Gasic V., Lucafo M., Decorti G., Pavlovic S., Stankovic B., Zukic B.   +6 more
core   +2 more sources

Measurements of 6-thioguanine nucleotide levels with TPMT and NUDT15 genotyping in patients with Crohn's disease.

PLoS ONE, 2017
The association between the 6-thioguanine nucleotide (6-TGN) level and clinical remission in Crohn's disease (CD) remains controversial. Thiopurine-induced leukopenia is a life-threatening complication of CD in Asians that was recently shown to strongly ...
Ji Hyeon Lee, Tae Jun Kim, Eun Ran Kim, Sung Noh Hong, Dong Kyung Chang, Li-Hwa Choi, Hye In Woo, Soo-Youn Lee, Young-Ho Kim   +8 more
doaj   +1 more source

Effects of PRPS1 I72 mutations on drug resistance in acute lymphoblastic leukemia and its mechanisms

Shanghai Jiaotong Daxue xuebao. Yixue ban, 2023
Objective·To study whether mutations at the I72 site of phosphoribosyl pyrophosphate synthetase 1 (PRPS1) can induce resistance in acute lymphoblastic leukemia (ALL) cells to thiopurine chemotherapy drugs 6-mercaptopurine (6-MP) and 6-thioguanine (6-TG),
CUI Zhiyan, CHEN Yao, TAO Yue, SHEN Shuhong, LI Hui   +4 more
doaj   +1 more source

6-thioguanine treatment in inflammatory bowel disease: A critical appraisal by a European 6-TG working party [PDF]

, 2006
Recently, the suggestion to use 6-thioguanine (6-TG) as an alternative thiopurine in patients with inflammatory bowel disease (IBD) has been discarded due to reports about possible (hepato) toxicity. During meetings arranged in Vienna and Prague in 2004,
Seiderer, J., Merwe, S. W. van der, Ochsenkühn, Thomas, Almer, S., Petritsch, W, Mulder, C. J. J, Seiderer, J, Vogelsang, H., Mulder, CJJ, Teml, A, Van Bodegraven, A. A., Teml, A., Herrlinger, K. R., Schwab, M., de Boer, NKH, Knoflach, P, van der Merwe, SW, Schwab, M, Reinisch, W., Ochsenkuhn, T, Reinisch, W, Knoflach, P., Petritsch, W., De Boer, N. K.H., De Boer, N. K. H, Van Der Merwe, S. W., Almer, Sven,, Vogelsang, H, Lukas, M., Ochsenkühn, T., van Bodegraven, AA, Lukas, M, Herrlinger, KR, Mulder, C. J.J., Bodegraven, A. A. van   +34 more
core   +1 more source

Alkylation of 6-thiopurine derivatives by the Mitsunobu reaction

, 2023
Alkylation of thiopurine derivatives with alcohols by the Mitsunobu reaction are reported in moderated to good yields. The method was applied in synthesis of number of thiopurine and thiopurine ribosides derivatives.
Bianca Nascimento Monteiro da Silva (14318156), Rafael Dias do Espírito Santo (14318153), Jaime A. Rabi (14318159), Vagner D. Pinho (1776868)   +3 more
core   +1 more source

Clinical utility of thiopurine metabolite monitoring in inflammatory bowel disease and its impact on healthcare utilization in Singapore

JGH Open, 2022
Background and Aim Thiopurines are recommended for maintenance of steroid‐free remission (SFR) in inflammatory bowel disease (IBD). Thiopurine metabolite monitoring (MM) is increasingly used in the West but remains novel in Singapore, with limited ...
Jia Qi Yeo, Hua Heng McVin Cheen, Amanda Wong, Teong Guan Lim, Balram Chowbay, Wai Fook Leong, Chunyan Wang, Ennaliza Salazar, Webber Pak Wo Chan, San Choon Kong, Wan Chee Ong   +10 more
doaj   +1 more source

Optimizing thiopurine therapy in children with acute lymphoblastic leukemia: A promising “MINT” sequencing strategy and therapeutic “DNA-TG” monitoring

Frontiers in Pharmacology, 2022
Thiopurines, including thioguanine (TG), 6-mercaptopurine (6-MP), and azathioprine (AZA), are extensively used in clinical practice in children with acute lymphoblastic leukemia (ALL) and inflammatory bowel diseases.
Hong-Li Guo, Yue-Tao Zhao, Yue-Tao Zhao, Wei-Jun Wang, Wei-Jun Wang, Na Dong, Na Dong, Ya-Hui Hu, Yuan-Yuan Zhang, Feng Chen, Li Zhou, Tao Li   +11 more
doaj   +1 more source

gene variants and thiopurine-induced leukopenia in patients with inflammatory bowel disease [PDF]

Intestinal Research, 2020
Thiopurine has been used to maintain remission and to reduce antidrug antibody formation in monoclonal antibody therapy in patients with inflammatory bowel disease (IBD). The use of thiopurine is limited by side effects such as leukopenia.
Katsuyoshi Matsuoka
doaj   +1 more source

Azathioprine‐induced severe myelosuppression accompanied by massive hair loss and painful oral ulcer in an autoimmune hepatitis patient with NUDT15 minor variant: A case report

Clinical Case Reports, 2021
This report highlights azathioprine‐induced severe myelosuppression in the patient with NUDT15 minor variant. This case report is particularly instructive because several typical symptoms are the clues to this critical adverse drug reaction.
Yu Takeuchi, Hidenao Noritake, Moe Matsumoto, Masahiro Umemura, Maho Yamashita, Kensuke Kitsugi, Shingo Takatori, Kazuyoshi Ohta, Jun Ito, Shin Shimoyama, Akira Kaysuya, Chiaki Maruyama, Kensuke Fukuchi, Satoshi Dohtan, Hiroe Sakata, Kazuhito Kawata   +15 more
doaj   +1 more source