Results 31 to 40 of about 19,377 (264)

6-thioguanine treatment in inflammatory bowel disease: A critical appraisal by a European 6-TG working party [PDF]

, 2006
Recently, the suggestion to use 6-thioguanine (6-TG) as an alternative thiopurine in patients with inflammatory bowel disease (IBD) has been discarded due to reports about possible (hepato) toxicity. During meetings arranged in Vienna and Prague in 2004,
A. Teml, A.A. van Bodegraven, Al Hadithy AF, Artlich A, Bean RHD, Buffet C, C.J.J. Mulder, Carter MJ, Daniel F, De Boer N, de Boer NK, de Boer NK, de Jong D, Derijks LJ, Dervieux T, Dubinsky MC, Ferlitsch A, Fonseca V, Gane E, Gearry RB, H. Vogelsang, Haboubi NY, Herrlinger KR, Herrlinger KR, Herrlinger KR, J. Seiderer, Jones MC, K.R. Herrlinger, Katzka DA, Lilleyman JS, M. Lukas, M. Schwab, Marinaki AM, McBride KL, N.K.H. de Boer, Naber AH, P. Knoflach, Russmann S, Rutgeerts P, S. Almer, S.W. van der Merwe, Sandborn W, Schaeffeler E, Seiderer J, Shastri S, T. Ochsenkühn, Teml A, Teml A, Teml A, Tiede I, van Dieren JM, W. Petritsch, W. Reinisch   +52 more
core   +1 more source

Pharmacogenetics of thiopurines

Cancer Drug Resistance, 2019
Polychemotherapeutic protocols for the treatment of pediatric acute lymphoblastic leukemia (ALL) always include thiopurines. Specific approaches vary in terms of drugs, dosages and combinations. Such therapeutic schemes, including risk-adapted intensity, have been extremely successful for children with ALL who have reached an outstanding 5-year ...
Raffaella Franca, ZUDEH, GIULIA, Sofia Pagarin, Marco Rabusin, Marianna Lucafò, Gabriele Stocco, Giuliana Decorti   +6 more
openaire   +3 more sources

Thiopurine pharmacogenomics: association of SNPs with clinical response and functional validation of candidate genes [PDF]

, 2014
Aim: We investigated candidate genes associated with thiopurine metabolism and clinical response in childhood acute lymphoblastic leukemia. Materials & methods: We performed genome-wide SNP association studies of 6-thioguanine and 6-mercaptopurine ...
Batzler, A., Cartwright, C.S., Fridley, B.L., Jenkins, G., Lennard, L., Li, F., Livshits, A., Matimba, A., Scully, S., Wang, L., Weinshilboum, R.   +10 more
core   +1 more source

gene variants and thiopurine-induced leukopenia in patients with inflammatory bowel disease [PDF]

Intestinal Research, 2020
Thiopurine has been used to maintain remission and to reduce antidrug antibody formation in monoclonal antibody therapy in patients with inflammatory bowel disease (IBD). The use of thiopurine is limited by side effects such as leukopenia.
Katsuyoshi Matsuoka
doaj   +1 more source

Clinical utility of thiopurine metabolite monitoring in inflammatory bowel disease and its impact on healthcare utilization in Singapore

JGH Open, 2022
Background and Aim Thiopurines are recommended for maintenance of steroid‐free remission (SFR) in inflammatory bowel disease (IBD). Thiopurine metabolite monitoring (MM) is increasingly used in the West but remains novel in Singapore, with limited ...
Jia Qi Yeo, Hua Heng McVin Cheen, Amanda Wong, Teong Guan Lim, Balram Chowbay, Wai Fook Leong, Chunyan Wang, Ennaliza Salazar, Webber Pak Wo Chan, San Choon Kong, Wan Chee Ong   +10 more
doaj   +1 more source

Scientometric mapping as a strategic intelligence tool for the governance of emerging technologies [PDF]

, 2014
How can scientometric mapping function as a tool of ’strategic intelligence’ to aid the governance of emerging technologies? The present paper aims to address this question by focusing on a set of recently developed scientometric techniques, namely ...
Hopkins, Michael, Leydersdorff, Loet, Rafols, Ismael, Rotolo, Daniele   +3 more
core   +2 more sources

Severe Complication of Thiopurine Treatment in a Young Woman with Crohn’s Disease

European Journal of Case Reports in Internal Medicine, 2021
Case Description: TA 28-year old woman receiving thiopurine treatment for Crohn’s disease presented with a systemic primo cytomegalovirus (CMV) infection affecting the gut (colitis), liver (hepatitis), lungs (pneumonitis) and eyes (retinitis).
Michiel PJ Voet, TGA Calon, MMC Hendriks, RM Schreuder   +3 more
doaj   +1 more source

Thiopurines: Recent Topics and Their Role in the Treatment of Inflammatory Bowel Diseases

Frontiers in Pharmacology, 2021
Ulcerative colitis (UC) and Crohn's disease (CD) are chronic inflammatory bowel diseases (IBD) of unknown etiology, characterized by repeated relapse and remission. The efficacy of thiopurine in IBD was first reported in the late 1960s.
Keiichi Tominaga, Takeshi Sugaya, Takanao Tanaka, Mimari Kanazawa, Makoto Iijima, Atsushi Irisawa   +5 more
doaj   +1 more source

Azathioprine‐induced severe myelosuppression accompanied by massive hair loss and painful oral ulcer in an autoimmune hepatitis patient with NUDT15 minor variant: A case report

Clinical Case Reports, 2021
This report highlights azathioprine‐induced severe myelosuppression in the patient with NUDT15 minor variant. This case report is particularly instructive because several typical symptoms are the clues to this critical adverse drug reaction.
Yu Takeuchi, Hidenao Noritake, Moe Matsumoto, Masahiro Umemura, Maho Yamashita, Kensuke Kitsugi, Shingo Takatori, Kazuyoshi Ohta, Jun Ito, Shin Shimoyama, Akira Kaysuya, Chiaki Maruyama, Kensuke Fukuchi, Satoshi Dohtan, Hiroe Sakata, Kazuhito Kawata   +15 more
doaj   +1 more source

TPMT and NUDT15 testing for thiopurine therapy: A major tertiary hospital experience and lessons learned

Frontiers in Pharmacology, 2022
Variants in thiopurine methyltransferase (TPMT) and nudix hydrolase 15 (NUDT15) are associated with an accumulation of cytotoxic metabolites leading to increased risk of drug-related toxicity with standard doses of thiopurine drugs.
Liuh Ling Goh, Chia Wei Lim, Khai Pang Leong, Khai Pang Leong, Kiat Hoe Ong, Kiat Hoe Ong   +5 more
doaj   +1 more source