Results 61 to 70 of about 16,205 (199)
Frontiers in Nutrition, 2023 IntroductionThiopurines, azathiopurine (AZA) and mercaptopurine (6-MP) have been regularly used in the treatment of inflammatory bowel disease (IBD). Despite optimized dosage adjustment based on the NUDT15 genotypes, some patients still discontinue or ...
Pan Li +15 more
doaj +1 more source
Systematic review: macrophage activation syndrome in inflammatory bowel disease [PDF]
, 2013 BACKGROUND: Recently, there have been increasingly frequent reports on the occurrence of macrophage activation syndrome (MAS) in patients with inflammatory bowel disease (IBD).
CASCIO, ANTONIO, COTTONE, Mario, Fries W
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Movement Disorders Clinical Practice, EarlyView.Abstract Background Microscopic colitis (MC) typically presents with chronic, non‐bloody watery diarrhea. Diagnosis requires endoscopy with colonic mucosal biopsies. The etiology is multifactorial, with several medications implicated, although only a few cases have been attributed to oral levodopa/dopa‐decarboxylase inhibitor (LDDCI) therapy.
Romana Hintner +10 more
wiley +1 more source
Inequities in inflammatory bowel disease care: a Tasmanian case study with proposed solutions
Internal Medicine Journal, EarlyView.Abstract There is well‐recognised inequity of care for people treated with inflammatory bowel disease (IBD) between metropolitan and regional areas. We aim to describe these barriers to care using Tasmania as a case example and to suggest solutions for addressing these barriers that can be used in Tasmania and beyond.
Alexander T Elford +8 more
wiley +1 more source
Scientific Reports, 2021 NUDT15 and TPMT variants are strong genetic determinants of thiopurine-induced hematological toxicity. Despite the impact of homozygous CRIM1 on thiopurine toxicity, several patients with wild-type NUDT15, TPMT, and CRIM1 experience thiopurine toxicity ...
Hyery Kim +14 more
doaj +1 more source
Role of Oxidative Stress Mediated by Glutathione-S-transferase in Thiopurines' Toxic Effects [PDF]
, 2015 Azathioprine (AZA), 6-mercaptopurine (6-MP), and 6-thioguanine (6-TG) are antimetabolite drugs, widely used as immunosuppressants and anticancer agents.
De Iudicibus, Sara +9 more
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Obesity Reviews, EarlyView.ABSTRACT Inflammatory bowel disease is a chronic inflammatory disorder affecting the gastrointestinal tract. It mainly comprises of Crohn's disease and ulcerative colitis. Its global prevalence has risen simultaneously with overweight and obesity among children and young people over the last decades.
Razan Algarni +2 more
wiley +1 more source
Therapeutic decision making in autoimmune and inflammatory disorders of the central nervous system in children. [PDF]
, 2016 Autoimmune and inflammatory disorders of the central nervous system can result in significant morbidity and mortality. Through the recognition of syndromes using diagnostic biomarkers, the clinician is now able to use immune suppressive therapies to ...
Dale, Rc, Lim, M., Nosadini, M
core +3 more sources
Frontiers in Pharmacology, 2022 Monitoring concentrations of thiopurine metabolites is used clinically to prevent adverse effects in patients on thiopurine drug therapy. We developed a LC–MS/MS method for the quantification of 6-thioguanine (6-TG) and 6-methylmercaptopurine (6-MMP) in ...
Amol O. Bajaj +10 more
doaj +1 more source
Thiopurines are negatively associated with anthropometric parameters in pediatric Crohn's disease. [PDF]
, 2018 AimTo determine the distribution of anthropometric parameter (AP)-z-scores and characterize associations between medications/serum biomarkers and AP-z-scores in pediatric Crohn's disease (CD).MethodsCD patients [< chronological age (CA) 21 years] were
Andrews, Howard +5 more
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