Results 111 to 120 of about 6,964 (243)

A Practical Non-Extraction Direct Liquid Chromatography Method for Determination of Thiopurine S-Methyltransferase Activity in Inflammatory Bowel Disease

Acta Medica Iranica, 2017
Thiopurine drugs remain pivotal therapies for the wide varieties of diseases such as inflammatory bowel disease (IBD). Here, thiopurine S-methyltransferase (TPMT) phenotype, the main metabolizing enzyme of thiopurine-drugs, was studied.
Fariborz Bahrehmand, Amir Kiani, Asad Vaisi-Raygani, Homayoun Bashiri, Mehdi Zobeiri, Ali Moini, Tayebeh Pourmotabbed   +6 more
doaj  

Population-Specific Distribution of TPMT Deficiency Variants and Ancestry Proportions in Ecuadorian Ethnic Groups: Towards Personalized Medicine

Therapeutics and Clinical Risk Management, 2023
Jennifer Gallardo-Cóndor,1 Pablo Naranjo,1 Sebastián Atarihuana,1 Dayana Coello,2 Patricia Guevara-Ramírez,3 Rodrigo Flores-Espinoza,4 Germán Burgos,5,6 Andrés López-Cortés,7,8 Alejandro Cabrera-Andrade9,10 1Facultad de Ingeniería y Ciencias Aplicadas ...
Gallardo-Cóndor J, Naranjo P, Atarihuana S, Coello D, Guevara-Ramírez P, Flores-Espinoza R, Burgos G, López-Cortés A, Cabrera-Andrade A   +8 more
doaj  

Development of a Scalable Pharmacogenomic Clinical Decision Support Service [PDF]

, 2014
Advances in sequencing technology are making genomic data more accessible within the healthcare environment. Published pharmacogenetic guidelines attempt to provide a clinical context for specific genomic variants; however, the actual implementation to ...
Brownstein, Catherine, Clinton, Catherine, Fusaro, Vincent A., Mandl, Kenneth D., Manzi, Shannon, Margulies, David, Savage, Sarah, Wolf, Wendy   +7 more
core  

Thiopurine Methyltransferase Intermediate Metabolizer Status and Thiopurine‐Associated Toxicity During Maintenance Therapy in Childhood Acute Lymphoblastic Leukemia [PDF]

, 2023
Ute I. Schwarz, Morgan Woldanski‐Travaglini, Valerie Swanston, Mariam Mikhail, Chantel Cacciotti, Elizabeth Cairney, Serina Patel, Jennifer Seelisch, Soumitra Tole, Marta Wilejto, Rommel G. Tirona, Richard B. Kim, Alexandra P. Zorzi   +12 more
openalex   +1 more source

Personalised medicine, unmet need or business strategy?

, 2013
Personalised medicine is a discipline that integrates pharmaceutical development with existing knowledge about the genetic and phenotypic factors that influence drug response.
Sáinz de la Fuente, G. (Graciela)
core  

Normal Ranges of Thiopurine Methyltransferase Activity Do Not Affect Thioguanine Nucleotide Concentrations With Azathioprine Therapy in Inflammatory Bowel Disease. [PDF]

Crohns Colitis 360, 2020
Jonason DE, Sievers T, Trocke L, Abraham JM, Vaughn BP.   +4 more
europepmc   +1 more source

NUDT15 polymorphisms are better than thiopurine S‐methyltransferase as predictor of risk for thiopurine‐induced leukopenia in Chinese patients with Crohn's disease [PDF]

, 2016
Xuan Zhu, Xiao‐Dong Wang, Kang Chao, M Zhi, Haitao Zheng, Haodi Ruan, Shunjie Xin, Ni Ding, Pin Jin Hu, Min Huang, Xiang Gao   +10 more
openalex   +1 more source

UEG Week 2025 Moderated Posters

United European Gastroenterology Journal, Volume 13, Issue S8, Page S189-S802, October 2025.
wiley   +1 more source

Pharmacogenetics – individualized treatment of genetic disorders [PDF]

, 2011
Farmakogenetika je grana znanosti koja proučava povezanost genotipa sa različitom reakcijom na terapiju nekim lijekovima. Potencijal farmakogenetike je velik jer će dobiveni rezultati istraživanja omogućiti i olakšati individualizirano liječenje ...
Biluš, Mirna
core   +2 more sources

Thiopurine methyltransferase screening before azathioprine therapy [PDF]

, 2006
V Gauba, Murrel Saldanha, Colin Vize, G. M. Saleh   +3 more
openalex   +1 more source