Results 171 to 180 of about 5,310 (212)

Pharmacogenetics of Thiopurine S-Methyltransferase and Thiopurine Therapy

Therapeutic Drug Monitoring, 2004
Most medications exhibit wide interpatient variability in their efficacy and toxicity. For many medications, these interindividual differences result in part from polymorphisms in genes encoding drug-metabolizing enzymes, drug transporters, and/or drug targets (eg, receptors, enzymes).
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Canine red blood cell thiopurine S-methyltransferase

Pharmacogenetics, 2002
Thiopurine S-methyltransferase (TPMT) plays an important role in the metabolism of thiopurine drugs. In humans, a common genetic polymorphism for TPMT is a major factor responsible for individual variation in the toxicity and therapeutic efficacy of these drugs. Dogs (Canis familiaris) are also treated with thiopurine drugs and, similar to humans, they
Oreste E, Salavaggione, Linda, Kidd, Janel L, Prondzinski, Carol L, Szumlanski, V Shane, Pankratz, Liewei, Wang, Lauren, Trepanier, Richard M, Weinshilboum   +7 more
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Assessment of Thiopurine S-Methyltransferase Activity in Patients Prescribed Thiopurines: A Systematic Review

Annals of Internal Medicine, 2011
The evidence for testing thiopurine S-methyltransferase (TPMT) enzymatic activity or genotype before starting therapy with thiopurine-based drugs is unclear.To examine the sensitivity and specificity of TPMT genotyping for TPMT enzymatic activity, reducing harm from thiopurine by pretesting, and the association of thiopurine toxicity with TPMT status ...
Booth, Ronald A, Ansari, Mohammed T, Loit, Evelin, Tricco, Andrea C, Weeks, Laura, Doucette, Steve, Skidmore, Becky, Sears, Margaret, Sy, Richmond, Karsh, Jacob   +9 more
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Synthesis of Modified Thiopurine Nucleosides for Structural Characterization of Human Thiopurine S-Methyltransferase

Nucleosides and Nucleotides, 1999
Synthesis of a number of photoactive thiopurine-containing nucleosides was described. S-methylation of the synthesized compounds in the course of the reaction catalyzed by recombinant human thiopurine S-methyltransferase was studied by UV-spectroscopy.
G A, Korshunova, E Y, Krynetski, M T, Mtchedlidze, D V, Agapkin, W E, Evans, N F, Krynetskaia   +5 more
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Pharmacogenomics: Catechol O-Methyltransferase to Thiopurine S-Methyltransferase

Cellular and Molecular Neurobiology, 2006
1. Pharmacogenomics is the study of the role of inheritance in variation in the drug response phenotype-a phenotype that can vary from adverse drug reactions at one end of the spectrum to lack of therapeutic efficacy at the other. 2. The thiopurine S-methyltransferase (TPMT) genetic polymorphism represents one of the best characterized and most ...
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Thiopurine S-methyltransferase as a target for drug interactions

European Journal of Clinical Pharmacology, 2005
The present study was undertaken to investigate the possible effects of various agents on thiopurine methyltransferase (TPMT) activity in red blood cells (RBCs) from patients with chronic inflammatory bowel disease (IBD).In three groups of patients with very high, normal and intermediate TPMT activity (each n=6), the inhibitory potential of furosemide,
Hua-Wen, Xin, Christine, Fischer, Matthias, Schwab, Ulrich, Klotz   +3 more
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Characterisation of novel defective thiopurine S-methyltransferase allelic variants

Biochemical Pharmacology, 2008
Human thiopurine S-methyltransferase (TPMT, EC 2.1.1.67) is a key enzyme in the detoxification of thiopurine drugs widely used in the treatment of various diseases, such as inflammatory bowel diseases, acute lymphoblastic leukaemia and rheumatic diseases.
A, Garat, C, Cauffiez, N, Renault, J M, Lo-Guidice, D, Allorge, D, Chevalier, N, Houdret, P, Chavatte, M A, Loriot, J L, Gala, F, Broly   +10 more
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Molecular cloning and tissue distribution of marmoset thiopurine S-methyltransferase

Drug Metabolism and Pharmacokinetics, 2020
The common marmoset (Callithrix jacchus) is a New World monkey that is increasingly used in pharmacological and toxicological studies. Thiopurine S-methyltransferase (TPMT) plays roles in the metabolism of widely used anticancer and anti-inflammatory drugs.
Shotaro, Uehara, Yasuhiro, Uno, Hiroshi, Yamazaki   +2 more
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Clinical Significance of Thiopurine S-Methyltransferase Gene Polymorphisms

Current Pharmacogenomics, 2007
Thiopurine methyltransferase (TPMT) is an important enzyme that catalyzes the S-methylation of a series of thiopurine drugs, including 6-mercaptopurine (6-MP), thioguanine and azathiopurine (AZA), to generate inactive methylated metabolites. Thiopurine drugs are widely used to treat malignancies such as acute lymphoblastic leukemia, autoimmune diseases
Zhou S.-F., Chowbay B.
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Phenotyping and Genotyping Studies of Thiopurine S-Methyltransferase in Kazaks

Pharmaceutical Research, 2005
This study was conducted to investigate the thiopurine S-methyltransferase (TPMT) activity distribution and gene mutations in Kazaks, and compared the results with those of other ethnic groups.Erythrocyte TPMT activity was measured in Kazaks (n = 327) via a validated high-performance liquid chromatography assay.
Wei, H., Zhou, S., Li, C., Zhang, J., Wu, J., Huang, M.   +5 more
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