Results 41 to 50 of about 5,819 (161)

How to diagnose and treat patients with inflammatory bowel disease [PDF]

Arhiv za farmaciju, 2017
Inflammatory bowel diseases (IBD) are idiopathic, chronic intestinal inflammatory diseases. IBD pathogenesis is related to altered immune response and its complex interaction with gut microbiota, genetic and environmental factors.
Sokić-Milutinović Aleksandra
doaj   +1 more source

Inequities in inflammatory bowel disease care: a Tasmanian case study with proposed solutions

Internal Medicine Journal, EarlyView.
Abstract There is well‐recognised inequity of care for people treated with inflammatory bowel disease (IBD) between metropolitan and regional areas. We aim to describe these barriers to care using Tasmania as a case example and to suggest solutions for addressing these barriers that can be used in Tasmania and beyond.
Alexander T Elford, Alyssa Pettersen, Emily Woods, Linda Boxhall, Zachiary Cooke, Anna Prebble, Jennifer Shoobridge, Jarrad Wilson, Scott Fanning   +8 more
wiley   +1 more source

Análisis de la determinación de niveles de tiopurínicos en pacientes pediátricos con enfermedad inflamatoria intestinal

Anales de Pediatría, 2020
Resumen: Introducción y objetivos: Las tiopurinas son fármacos muy empleados para el mantenimiento de la remisión en pacientes con enfermedad inflamatoria intestinal. Se conocen cuáles son los niveles plasmáticos óptimos, y existe controversia acerca de
Rafael Martín-Masot, María Pilar Ortiz Pérez, Natalia Ramos Rueda, Juliana Serrano Nieto, Javier Blasco-Alonso, Víctor Manuel Navas-López   +5 more
doaj   +1 more source

Inflammatory Bowel Disease in Children and Young People Living With Overweight or Obesity: A Critical Narrative Review

Obesity Reviews, EarlyView.
ABSTRACT Inflammatory bowel disease is a chronic inflammatory disorder affecting the gastrointestinal tract. It mainly comprises of Crohn's disease and ulcerative colitis. Its global prevalence has risen simultaneously with overweight and obesity among children and young people over the last decades.
Razan Algarni, Efstathia Papada, Adrian Brown   +2 more
wiley   +1 more source

Direct evidence of singlet molecular oxygen [O2 (1Δg)] production from UVA excited 6‐thioguanine

Photochemistry and Photobiology, EarlyView.
6‐Thioguanine (6‐TGua) is incorporated into DNA as a purine analogue, inhibiting cell replication. Patients treated with 6‐TGua are more prone to developing skin cancer due to the photoexcitation of 6‐TGua by UVA radiation (as illustrated in the Jablonski diagram). Upon exposure to UVA, the excited 6‐TGua generates 1O2.
André L. Lopes, Fernanda M. Prado, Helena C. Junqueira, Marisa H. G. Medeiros, Graziella E Ronsein, Jean Cadet, Paolo Di Mascio   +6 more
wiley   +1 more source

Real-World Experience with AGA Guidelines in the Management of Crohn’s Disease following Ileocolonic Resection: A Retrospective Cohort Study

Gastroenterology Research and Practice, 2020
Background. Postoperative endoscopic recurrence (PER) is common in patients with Crohn’s disease (CD) after surgery. The impact of the American Gastroenterological Association (AGA) guideline adherence on PER in real life remains unclear. Methods.
Shasha Tang, Wei Liu, Weilin Qi, Tunan Yu, Qian Cao, Xiaolong Ge, Wei Zhou   +6 more
doaj   +1 more source

Model‐Based Strategy for 6‐Mercaptopurine Treatment in Acute Lymphoblastic Leukemia Maintenance Phase: Prediction of 6‐TGN and 6‐MMP Concentrations to Optimize Treatment

Pediatric Blood &Cancer, Volume 73, Issue 4, April 2026.
ABSTRACT Introduction Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer. The pro‐drug 6‐mercaptopurine (6‐MP), essential during maintenance, is converted into active 6‐thioguanine (6‐TGN) and toxic 6‐methylmercaptopurine (6‐MMP) metabolites, resulting in marked variability in efficacy and toxicity.
Anne Ravix, Anaïs Maillat, Eva Choong, Chantal Csajka, Monia Guidi, Francesco Ceppi   +5 more
wiley   +1 more source

The Impact of Azathioprine-Associated Lymphopenia on the Onset of Opportunistic Infections in Patients with Inflammatory Bowel Disease.

PLoS ONE, 2016
BackgroundThiopurines are known to cause lymphopenia (
Marius Vögelin, Luc Biedermann, Pascal Frei, Stephan R Vavricka, Sylvie Scharl, Jonas Zeitz, Michael C Sulz, Michael Fried, Gerhard Rogler, Michael Scharl   +9 more
doaj   +1 more source

Thiopurine 6TG treatment increases tumor immunogenicity and response to immune checkpoint blockade

OncoImmunology, 2023
Immune-checkpoint inhibitors (ICI) are highly effective in reinvigorating T cells to attack cancer. Nevertheless, a large subset of patients fails to benefit from ICI, partly due to lack of the cancer neoepitopes necessary to trigger an immune response ...
Loulieta Nazerai, Shona Caroline Willis, Patricio Yankilevich, Luca Di Leo, Francesca Maria Bosisio, Alex Frias, Corine Bertolotto, Jacob Nersting, Maria Thastrup, Soren Buus, Allan Randrup Thomsen, Morten Nielsen, Kristoffer Staal Rohrberg, Kjeld Schmiegelow, Daniela De Zio   +14 more
doaj   +1 more source

Personalization of thiopurine therapy: Current recommendations and future perspectives

Acta Pharmaceutica
Despite great therapeutic advances in the field of biologics, small synthetic molecules such as thiopurines, including azathioprine, mercaptopurine, and thioguanine, remain an important therapeutic pillar in the treatment of inflammatory bowel disease ...
Urbančič Dunja, Pasha Flaka, Šmid Alenka, Mlinarič-Raščan Irena   +3 more
doaj   +1 more source