Results 51 to 60 of about 5,819 (161)

Successful cyclosporin and ustekinumab combination therapy in a patient with severe steroid-refractory ulcerative colitis

Therapeutic Advances in Gastroenterology, 2020
The therapeutic management of patients with severe steroid-refractory ulcerative colitis still represents a critical clinical challenge. In this setting, cyclosporin is an effective and rapidly acting induction treatment that is applied in combination ...
Ingo Ganzleben, Carol Geppert, Lourdes Osaba, Simon Hirschmann, Andreas Nägel, Christian Glück, Arthur Hoffman, Timo Rath, Daniel Nagore, Markus F. Neurath, Raja Atreya   +10 more
doaj   +1 more source

The persistence of chronic opioid use in patients with inflammatory bowel disease—A nationwide cohort study

British Journal of Clinical Pharmacology, Volume 92, Issue 3, Page 879-890, March 2026.
Aims Pain is common in patients with Crohn's disease (CD) and ulcerative colitis (UC), and a substantial proportion develop chronic opioid use (COU). We examined the persistence of COU over time and identified factors predicting persistent use. Methods This nationwide Danish cohort study included patients with an initial period of COU (definition: ≥3 ...
Bente Mertz Nørgård, Caroline Theilgaard Thorarinsson, Jan Nielsen, Mette Louise Andersen, Jens Kjeldsen, Torben Knudsen, Rahul S. Dalal   +6 more
wiley   +1 more source

Thiopurine S-methyltransferase polymorphisms: efficient screening method for patients considering taking thiopurine drugs [PDF]

European Journal of Clinical Pharmacology, 2004
More than 11% of the Caucasian population are heterozygous or homozygous carriers of thiopurine S-methyltransferase (TPMT) mutants and are at risk for toxic side effects when treated with thiopurine drugs. Therefore, screening for TPMT polymorphisms in a patient prior to prescribing these agents is recommended. The goal of this study was to determine a
Wusk, Barbara, Kullak-Ublick, G A, Rammert, C, von Eckardstein, A, Fried, M, Rentsch, K M   +5 more
openaire   +3 more sources

Gold–Thiopurine and Thioguanine Platforms for Chemotherapy and Photodynamic Therapy

ChemistryEurope, Volume 4, Issue 3, March 2026.
Gold(I)–thiopurine complexes bearing chromophores and phosphine or N‐heterocyclic carbene ligands were developed as multimodal chemo‐photodynamic agents. They show good stability, moderate lipophilicity, and tunable photoresponse. 6‐TG enhances dark cytotoxicity, 6‐MP improves phototoxicity, and PPh3/NBD provide the most efficient photoactivation ...
Laura Agulló, Juan Carlos Pérez‐Sánchez, María Gil‐Moles, M. Concepción Gimeno   +3 more
wiley   +1 more source

Pharmacogenetics of thiopurine therapy: from thiopurine S-methyltransferase to S-adenosylmethionine [PDF]

BMC Pharmacology, 2009
Background The efficiency and safety of the thiopurine therapy rely on the concentration of patient’s cytotoxic thioguanine nucleotides (TGN), which in turn depend on the deactivation of thiopurine drugs by thiopurine S-methyltransferase (TPMT). The activity of TPMT largely depends on the presence of genetic polymorphisms. Determination of mutations in
Mlinarič-Raščan, Irena, Milek, Miha, Karas-Kuželički, Nataša   +2 more
openaire   +1 more source

Loss of Response to Anti‐Tumor Necrosis Factor Alpha Therapy in Patients With Inflammatory Bowel Disease: A Real‐World Comparison of Combination Therapy Versus Monotherapy

JGH Open, Volume 10, Issue 3, March 2026.
ABSTRACT Objectives The success of anti‐TNFα agents has changed the landscape of treatment for inflammatory bowel diseases (IBD). One major limitation to this success is the secondary loss of response (sLOR) phenomenon. Combination therapy with immunomodulating agents has been shown to be effective in reducing the sLOR process.
Faris Chater, Maja Kopczynska, Mahdi Saeidinejad, Richard Gentry, Jack Smith, Catherine Stansfield, Arash Assadsangabi   +6 more
wiley   +1 more source

Therapy de‐escalation in paediatric patients with inflammatory bowel disease in remission: Data analysis from the CEDATA registry

Journal of Pediatric Gastroenterology and Nutrition, Volume 82, Issue 3, Page 690-698, March 2026.
Abstract Objectives There are no standardized criteria about stepping down from combination therapy (immunomodulator and tumor necrosis factor (TNF)‐alpha‐inhibitors) in children with inflammatory bowel disease (IBD) to reduce risk for side effects. Our aim was to describe how de‐escalation has been performed in a large paediatric cohort and to find ...
Sila Cekin, Christoph Huenseler, Serdar Cantez, Ilse Broekaert, Jan de Laffolie, CEDATA‐GPGE® Study Group   +5 more
wiley   +1 more source

What Happens to Patients with Inflammatory Bowel Disease Who Are Intolerant to Thiopurines?

Inflammatory Intestinal Diseases
Introduction: The clinical consequences for patients with inflammatory bowel disease (IBD) who stop treatment owing to side effects have not been fully investigated.
Helena Gensmyr-Singer, Pontus Karling
doaj   +1 more source

Acute thiopurine overdose: analysis of reports to a National Poison Centre 1995-2013.

PLoS ONE, 2014
Literature regarding acute human toxicity of thiopurines is limited to a handful of case reports. Our objectives were to describe all cases of overdose with thiopurines reported to the Swiss Toxicological Information Centre between 1995-2013.
Claudia Gregoriano, Alessandro Ceschi, Christine Rauber-Lüthy, Hugo Kupferschmidt, Nicholas R Banner, Stephan Krähenbühl, Anne B Taegtmeyer   +6 more
doaj   +1 more source

Adequate vitamin D is associated with favorable disease outcome in children with inflammatory bowel disease receiving anti‐tumor necrosis factor alpha therapy

Journal of Pediatric Gastroenterology and Nutrition, Volume 82, Issue 3, Page 708-717, March 2026.
Abstract Objectives Deficiency of serum 25‐hydroxyvitamin D [25(OH)D] was associated with decreased short‐term response to anti‐tumor necrosis factor‐alpha (TNF‐α) agents in adults with inflammatory bowel disease (IBD). The aim of this study was to evaluate the association between serum 25(OH)D levels and the outcome of children with IBD undergoing ...
Adi Anafy, Yaara Manor, Maayan Shemer, Reut Doyev, Eytan Damari, Shlomi Cohen, Anat Yerushalmy‐Feler   +6 more
wiley   +1 more source