Results 11 to 20 of about 5,992 (210)

Lipophilicity Studies on Thiosemicarbazide Derivatives [PDF]

Molecules, 2017
The lipophilicity of two series of thiosemicarbazide derivatives was assessed by the RP-HPLC method with the RP-18 chromatographic column and the methanol–water mixture as the mobile phase. Distribution coefficients logPHPLC were compared to calculated values generated by commonly used AClogP software and quantum chemical calculations.
Monika Wujec, Piotr Paneth, Tomasz Plech   +2 more
exaly   +6 more sources

Evolution of Thiosemicarbazones: From First‐ to Second‐Generation Metal Chelators and Their Reactive Oxygen Species‐Mediated Effects in Melanoma [PDF]

ChemistryOpen
Worldwide, melanoma remains a significant public health concern, with an estimated 325,000 new cases and 57,000 deaths recorded in 2020. If current trends persist, these figures are projected to rise to 510,000 new cases and 96,000 deaths annually by ...
Rohina Alim, Scott D. Andrew, Christopher J. Parkinson   +2 more
doaj   +3 more sources

Synthesis and Anthelmintic Activity of New Thiosemicarbazide Derivatives—A Preliminary Study

Molecules, 2020
Parasitic infections caused by different species of intestinal helminths still poses a threat to public health. There is a need to search for new, effective anthelmintic drugs. A series of novel thiosemicarbazides were synthesized and evaluated for their
Anna Bogucka-Kocka, Monika Wujec, Przemysław Kołodziej   +2 more
exaly   +4 more sources

THE ANTI-NEOPLASTIC ACTIVITY OF THE COORDINATIVE COMPOUNDS, THIOSEMICARBAZIDE DERIVATES [PDF]

Arta Medica, 2023
Background. Thiosemicarbazide derivates are considered potential compounds of the antitumor drugs, with a large spectrum of biological properties. The aim of the research was to reflect the actual progress in studies on thiosemicarbazide derivates ...
Valeriana Pantea, Evelina Lesnic
doaj   +2 more sources

Anticancer Activity and Safety Profile of Novel 1-(4-Fluorophenoxyacetyl)-4-substituted Thio/Semicarbazide Derivatives [PDF]

Molecules
Compounds with thiosemicarbazide and semicarbazide scaffolds are among the most promising structures in medicinal chemistry due to the possibility of forming multiple hydrogen bonds.
Paweł Kozyra, Ewelina Humeniuk, Zbigniew Karczmarzyk, Adrian Borzęcki, Grzegorz Adamczuk, Agnieszka Korga-Plewko, Waldemar Wysocki, Monika Pitucha   +7 more
doaj   +2 more sources

Chemoproteomic identification of molecular targets of antifungal prototypes, thiosemicarbazide and a camphene derivative of thiosemicarbazide, in Paracoccidioides brasiliensis [PDF]

PLOS ONE, 2018
Paracoccidioidomycosis (PCM) is a neglected human systemic disease caused by species of the genus Paracoccidioides. The disease attacks the host's lungs and may disseminate to many other organs. Treatment involves amphotericin B, sulfadiazine, trimethoprim-sulfamethoxazole, itraconazole, ketoconazole, or fluconazole.
Joyce Villa Verde Bastos Borba, Sinji Borges Ferreira Tauhata, Cecília Maria Alves de Oliveira, Monique Ferreira Marques, Alexandre Melo Bailão, Célia Maria de Almeida Soares, Maristela Pereira   +6 more
openaire   +4 more sources

Fungicidal Activity of the Nitroimidazole-Thiosemicarbazide Derivative 1-[(1-methyl-4-nitroimidazol-2-yl)carbonyl]-4-(3-methylophenyl)thiosemicarbazide Against <i>Trichophyton</i> spp. Dermatophytes. [PDF]

Pathogens
Dermatophytosis caused by Trichophyton spp. represents a growing public health concern, exacerbated by the increasing prevalence of difficult-to-treat infections and the emergence of resistance to standard antifungal agents, such as terbinafine.
Andrzejczuk S, Wujec M, Świątek Ł, Kosikowska U.   +3 more
europepmc   +2 more sources

Structural Modifications of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): New Horizons in Antimicrobial Drug Discovery. [PDF]

Arch Pharm (Weinheim)
This review provides a comprehensive analysis of the molecular modifications applied to NSAIDs to develop novel antimicrobial agents. By focusing on structural changes and their impact on biological activity, the study highlights innovative strategies to combat the global challenge of antimicrobial resistance.
Koçak Aslan E, Karagüzel A, Gündüz MG.   +2 more
europepmc   +2 more sources

Bis(μ-thiosemicarbazide-κ3N1,S:S;κ3S:N1,S)bis[(dimethylformamide-κO)(thiosemicarbazide-κ2N1,S)cadmium(II)] tetrakis(2,4,6-trinitrophenolate): synthesis, crystal structure and Hirshfeld surface analysis

Acta Crystallographica Section E: Crystallographic Communications
In the title complex salt, [Cd2(C3H7NO)2(CH5N3S)4](C6H2N3O7)4, (I), the binuclear cation is located about a crystallographic center of symmetry. The asymmetric unit of the complex cation is composed of two bidentate thiosemicarbazide ligands and one ...
R. Santhakumari, K. Ramamurthi, Manpreet Kaur, Jerry P. Jasinski, Suresh Sagadevan, Helen Stoeckli-Evans   +5 more
doaj   +2 more sources

Preparation of new Schiff bases based on thiosemicarbazide and evaluation of their inhibitory properties on corrosion of carbon steel in acidic environment [PDF]

شیمی کاربردی روز, 2023
In this work, two Schiff bases named 1-(2-hydroxybenzylidene)-4-phenylthiosemicarbazide (2-HTSC) and 1-(3-hydroxybenzylidene)-4-phenylthiosemicarbazide (3-HTSC) were synthesized and evaluated their inhibitory properties on corrosion of carbon steel in 15%
Homayoon Eslamizadeh, Asadollah Mohammadi, Somayeh Mohammadi   +2 more
doaj   +1 more source