Results 11 to 20 of about 6,253 (217)

Lipophilicity Studies on Thiosemicarbazide Derivatives [PDF]

Molecules, 2017
The lipophilicity of two series of thiosemicarbazide derivatives was assessed by the RP-HPLC method with the RP-18 chromatographic column and the methanol–water mixture as the mobile phase. Distribution coefficients logPHPLC were compared to calculated values generated by commonly used AClogP software and quantum chemical calculations.
Agata Paneth, Anna Hawrył, Tomasz Plech, Mirosław Hawrył, Ryszard Świeboda, Dominika Janowska, Monika Wujec, Piotr Paneth   +7 more
openaire   +5 more sources

Effects of Thiosemicarbazide on Audiogenic Seizures

Psychological Reports, 1966
35 male albino rats were tested for audiogenic seizures and then divided into 5 time-delay groups. These time delays preceded bell-can stimulations following the administration of thiosemicarbazide. It was found that 1-hr. and 5-hr. delays resulted in an increase in the number of seizures.
E E, Benson, H C, Salzberg
openaire   +3 more sources

Metal complexes of thiosemicarbazide: Vibrational analysis of nickel(II) thiosemicarbazide complexes and their deutero isotopomers

Australian Journal of Chemistry, 1977
The assignments of the in-plane vibrations of the ionic and neutral nickel(II) thiosemicarbazide complexes, Ni(Htsc)2Cl2 and Ni(tsc)2, and their deuterated molecules have been made with the aid of normal coordinate treatments. The out-of-plane vibrations have been assigned empirically.
K Geetharani, DN Sathyanarayana
openaire   +2 more sources

Chemoproteomic identification of molecular targets of antifungal prototypes, thiosemicarbazide and a camphene derivative of thiosemicarbazide, in Paracoccidioides brasiliensis [PDF]

PLOS ONE, 2018
Paracoccidioidomycosis (PCM) is a neglected human systemic disease caused by species of the genus Paracoccidioides. The disease attacks the host's lungs and may disseminate to many other organs. Treatment involves amphotericin B, sulfadiazine, trimethoprim-sulfamethoxazole, itraconazole, ketoconazole, or fluconazole.
Joyce Villa Verde Bastos Borba, Sinji Borges Ferreira Tauhata, Cecília Maria Alves de Oliveira, Monique Ferreira Marques, Alexandre Melo Bailão, Célia Maria de Almeida Soares, Maristela Pereira   +6 more
openaire   +4 more sources

A Thiosemicarbazone Schiff Base and Its Titanium(IV) Complexes: Spectral Analysis, DFT Studies, and Biological Evaluation. [PDF]

Chem Biodivers
DFT computations are used to analyze the electronic structure, stability, and reactivity profiles of a new Schiff base ligand and its Ti(IV) complexes and are characterized by elemental analysis, IR, 1H NMR, 13C NMR, and mass spectrometry and screened for antimicrobial activities against E. coli, S. aureus, ESBL, MRSA, Mtb, A.
Ghanghas P, Yadav A, Kamboj A, Choudhary A, Kour M, Kumar D, Poonia K.   +6 more
europepmc   +2 more sources

Synthesis, Moleculer Modeling, and Carbonic Anhydrase Inhibitor Effects of Novel 1‐(1‐benzyl‐2‐oxoindolin‐3‐ylidene)‐4‐(3‐sulfamoylphenyl)thiosemicarbazides [PDF]

ChemMedChem
Novel 1‐(1‐benzyl‐2‐oxoindolin‐3‐ylidene)thiosemicarbazides (6a–l) bearing a 3‐sulfamoylphenyl moiety selectively inhibited the tumor‐associated hCA IX and XII isoforms over hCA I and II isoforms at the nanomolar levels. Compounds 6k and 6f emerged as the most potent inhibitors of hCA IX and XII, respectively.
Apaydın Ç, Cinek T, Nadaroğlu H, Karalı N.   +3 more
europepmc   +2 more sources

SYNTHESIS, CHARACTERIZATION AND ANTIBACTERIAL EVALUATION OF NOVEL Β- LACTAM AND THIAZOLIDIN-4-ONE DERIVATIVES HAVING THIADIAZINYL RING [PDF]

Bulletin of Pharmaceutical Sciences. Assiut University, 2023
Since ancient times, several heterocyclic scaffolds have been recognized as possessing a wide spectrum of anti-infectious pharmacological properties. The present work aimed to synthesize and to perform antibacterial screening of some novel heterocyclic ...
Krishna Srivastava, Ram Prakash, Raj Singh, Abhishek Srivastava, Rishi Vishnoi   +4 more
doaj   +1 more source

Reactivity of 4,5-Dichlorophthalic Anhydride towards Thiosemicarbazide and Amines: Synthesis, Spectroscopic Analysis, and DFT Study

Molecules, 2022
The cyclic anhydrides are broadly employed in several fields, such as the chemical, plastic, agrochemical, and pharmaceutical industries. This study describes the chemical reactivity of 4,5-dichlorophthalic anhydride towards several nucleophiles ...
Hatem A. Abuelizz, Ahmed H. Bakheit, Mohamed Marzouk, Mohamed M. Abdellatif, Rashad Al-Salahi   +4 more
doaj   +1 more source

N-Substituted 2-(Benzenosulfonyl)-1-Carbotioamide Derivatives Exert Antimicrobial and Cytotoxic Effects via Aldehyde Dehydrogenase Pathway: Synthesis, In Silico and In Vitro Studies

Pharmaceuticals, 2023
A series of N-Substituted 2-(benzenosulfonyl)-1-carbotioamide derivatives (WZ1–WZ4) were synthesized and characterized using spectral methods. A comprehensive activity study was performed for each compound.
Lucja Walczak-Nowicka, Anna Biernasiuk, Wojciech Ziemichód, Zbigniew Karczmarzyk, Mateusz Kwaśnik, Paweł Kozyra, Waldemar Wysocki, Agnieszka Stenzel-Bembenek, Dorota Kowalczuk, Mariola Herbet, Monika Pitucha   +10 more
doaj   +1 more source

Optimized Synthesis of New Thiosemicarbazide Derivatives with Tuberculostatic Activity

, 2021
Original results are presented in the field of research that addresses the extension of the reaction of residue of acyl-thiosemicarbazide fixation on the structure of 5-nitrobenzimidazole by a sulphonic group.
Dan Gheorghe Dimitriu, Marcel Popa, Corina Cheptea, Diana David, Corina Popovici, Cristina-Maria Pavel, Valeriu Sunel, Dana Ortansa Dorohoi, Valentina Closca   +8 more
core   +1 more source