Results 31 to 40 of about 5,992 (210)

Thiosemicarbazide Toxicity in Mice.

Experimental Biology and Medicine, 1952
Summary1. Fatal convulsions follow the administration of doses of 20 mg of thiosemicarbazide (TSC)/kg or more to mice. 2. Semicarbazide is approximately 1/20 as toxic as thiosemicarbazide, while aminoguanidine produces no toxic symptoms at a dose of 650 mg/kg. 3.
R E, PARKS, G W, KIDDER, V C, DEWEY
openaire   +2 more sources

Inhibitory effect of coumarin derivatives on apple (cv. Idared) polyphenol oxidase

Croatian Journal of Food Science and Technology, 2017
Inhibitory effect of 32 coumarin derivatives (20 Schiff bases, 5 thiosemicarbazides, 5 thiazolidinones, and their precursors, 7-hydroxy-4-methylcoumarin and 4-methylcoumarin-7-yl hydrazine carboxylate) on partially purified apple polyphenol oxidase was ...
I. Strelec, P. Burić, Irena Janković, T. Kovač, Maja Molnar   +4 more
doaj   +1 more source

Exploring Novel Pyridine Carboxamide Derivatives as Urease Inhibitors: Synthesis, Molecular Docking, Kinetic Studies and ADME Profile

Pharmaceuticals, 2022
The rapid development of resistance by ureolytic bacteria which are involved in various life-threatening conditions such as gastric and duodenal cancer has induced the need to develop a new line of therapy which has anti-urease activity.
Ayesha Naseer, Faisal Abdulrhman Osra, Asia Naz Awan, Aqeel Imran, Abdul Hameed, Syed Adnan Ali Shah, Jamshed Iqbal, Zainul Amiruddin Zakaria   +7 more
doaj   +1 more source

1-[1-(4-Nitrophenyl)ethylidene]thiosemicarbazide [PDF]

, 2008
The title compound, C9H10N4O2S, was prepared by the reaction of 1-(4-nitrophenyl)ethanone and thiosemicarbazide in ethanol at 367 K. There are weak intermolecular N—H...S and N—H...O hydrogen-bonding interactions in the crystal ...
Fang-Fang Jian, Yu-Feng Ding, Jian-Gang Wang   +2 more
core   +1 more source

Synthesis, Reactions and Antimicrobial Activities of 8-Ethoxycoumarin Derivatives

Molecules, 2012
Condensation of 3-acetyl-8-ethoxycoumarin (3) with thiosemicarbazide gave ethylidenehydrazinecarbothioamide 5, which was transformed into the thiazolidin-4-one derivatives 6,7. Interaction of 3 with DMF/POCl3 gave b-chloroacroline derivative 8. Treatment
Mostafa M. Khafagy, Ahmed H. Bedair, Fathy A. Eid, Kamal A. Ahmed, Ahmed M. El-Agrody, Hany M. Mohamed, Ashraf H. F. Abd El-Wahab   +6 more
doaj   +1 more source

2-(2-Imino-1-methylimidazolidin-4-ylidene)hydrazinecarbothioamide

Molbank, 2012
A new thiosemicarbazone, 1-methyl-2-imino-N-(methanethialdiamine)-yl-4-iminoimidazolidin was synthesized and its UV-VIS, IR, and NMR spectroscopic data and CHN analysis are presented.
Abdul Amir H. Kadhum, Abu Bakar Mohamad, Ahmed A. Al-Amiery   +2 more
doaj   +1 more source

Synthesis and Biological Evaluation of 1-(2-(6-Methoxynaphthalen-2-yl)-6-methylnicotinoyl)-4-Substituted Semicarbazides/Thiosemicarbazides as Anti-Tumor Nur77 Modulators

Molecules, 2022
Nur77 is an orphan nuclear receptor that participates in the occurrence and development of a variety of tumors. Many agonists of Nur77 have been reported to have significant anticancer effects.
Hongyu Hu, Jiangang Huang, Yin Cao, Zhaolin Zhang, Fengming He, Xianfu Lin, Qi Wu, Shengxian Zhao   +7 more
doaj   +1 more source

1-(Cycloheptylidene)thiosemicarbazide [PDF]

IUCrData, 2019
The asymmetric unit of the title compound, C8H15N3S, contains two independent molecules. In both molecules, the seven-membered cycloheptane ring adopts a chair conformation. An intramolecular N—H...N hydrogen bond is observed in both molecules, forming S(5) graph-set motifs.
Mulveer Singh, Sumati Anthal, Sandeep S. Sankpal, Madhukar B. Deshmukh, Rajni Kant   +4 more
openaire   +2 more sources

Synthesis and Antimicrobial Activity of Some New 1,3,4-Thiadiazole and 1,2,4-Triazole Compounds Having a D,L-Methionine Moiety

Molecules, 2007
New 1,3,4-thiadiazole, 5a-e, and 1,2,4-triazolecompounds 6a-c, containing a D,L-methionine moiety were synthesized by intramolecular cyclization of 1,4-disubstituted thiosemicarbazides 4a-e in acid and alkaline media, respectively.
Aurel Pui, Marcel Popa, Valeriu Sunel, Lenuta Profire, Otilia Pintilie   +4 more
doaj   +1 more source

Synthesis and Structure Determination of Substituted Thiazole Derivatives as EGFR/BRAF^V600E Dual Inhibitors Endowed with Antiproliferative Activity

Pharmaceuticals, 2023
2,3,4-trisubstituted thiazoles 3a–i, having a methyl group in position four, were synthesized by the reaction of 1,4-disubstituted thiosemicarbazides with chloroacetone in ethyl acetate/Et3N at room temperature or in ethanol under reflux.
Lamya H. Al-Wahaibi, Essmat M. El-Sheref, Alaa A. Hassan, S. Bräse, M. Nieger, Bahaa G. M. Youssif, Mahmoud A. A. Ibrahim, Hendawy N. Tawfeek   +7 more
doaj   +1 more source