Results 31 to 40 of about 6,253 (217)

Synthesis and Antimicrobial Activity of Some New 1,3,4-Thiadiazole and 1,2,4-Triazole Compounds Having a D,L-Methionine Moiety

Molecules, 2007
New 1,3,4-thiadiazole, 5a-e, and 1,2,4-triazolecompounds 6a-c, containing a D,L-methionine moiety were synthesized by intramolecular cyclization of 1,4-disubstituted thiosemicarbazides 4a-e in acid and alkaline media, respectively.
Aurel Pui, Marcel Popa, Valeriu Sunel, Lenuta Profire, Otilia Pintilie   +4 more
doaj   +1 more source

Study of the Relationships between the Structure, Lipophilicity and Biological Activity of Some Thiazolyl-carbonyl-thiosemicarbazides and Thiazolyl-azoles

Molecules, 2015
Lipophilicity, as one of the most important physicochemical parameters of bioactive molecules, was investigated for twenty-two thiazolyl-carbonyl-thiosemicarbazides and thiazolyl-azoles.
Radu Tamaian, Augustin Moţ, Radu Silaghi-Dumitrescu, Ioana Ionuţ, Anca Stana, Ovidiu Oniga, Cristina Nastasă, Daniela Benedec, Brînduşa Tiperciuc   +8 more
doaj   +1 more source

Synthesis and Biological Evaluation of 1-(2-(6-Methoxynaphthalen-2-yl)-6-methylnicotinoyl)-4-Substituted Semicarbazides/Thiosemicarbazides as Anti-Tumor Nur77 Modulators

Molecules, 2022
Nur77 is an orphan nuclear receptor that participates in the occurrence and development of a variety of tumors. Many agonists of Nur77 have been reported to have significant anticancer effects.
Hongyu Hu, Jiangang Huang, Yin Cao, Zhaolin Zhang, Fengming He, Xianfu Lin, Qi Wu, Shengxian Zhao   +7 more
doaj   +1 more source

Synthesis and Structure Determination of Substituted Thiazole Derivatives as EGFR/BRAF^V600E Dual Inhibitors Endowed with Antiproliferative Activity

Pharmaceuticals, 2023
2,3,4-trisubstituted thiazoles 3a–i, having a methyl group in position four, were synthesized by the reaction of 1,4-disubstituted thiosemicarbazides with chloroacetone in ethyl acetate/Et3N at room temperature or in ethanol under reflux.
Lamya H. Al-Wahaibi, Essmat M. El-Sheref, Alaa A. Hassan, S. Bräse, M. Nieger, Bahaa G. M. Youssif, Mahmoud A. A. Ibrahim, Hendawy N. Tawfeek   +7 more
doaj   +1 more source

Coumarinyl Thiosemicarbazides as Antimicrobial Agents

Pharmaceutical Chemistry Journal, 2018
A two series of coumarinyl thiosemicarbazides were synthesized. One series derived from coumarin core substituted in position 7 and another from coumarin core substituted in position 4. All compounds were obtained in reaction of corresponding hydrazide and various isothiocyanates.
Molnar, Maja, Tomić, Marinko, Pavić, Valentina   +2 more
openaire   +3 more sources

Retention Behavior of Anticancer Thiosemicarbazides in Biomimetic Chromatographic Systems and In Silico Calculations

Molecules, 2023
Chromatographic methods, apart from in silico ones, are commonly used rapid techniques for the evaluation of certain properties of biologically active compounds used for their prediction of pharmacokinetic processes.
Marek Studziński, Paweł Kozyra, Monika Pitucha, Bogusław Senczyna, Joanna Matysiak   +4 more
doaj   +1 more source

Flotation-separation of toxic metal ions from aqueous solutions using thiosemicarbazide derivatives as chelating agents and oleic acid as a surfactant [PDF]

, 2010
A simple and rapid procedure was developed for flotation-separation of toxic metal ions namely Hg2+, Mn2+ and Cd2+ from aqueous solutions. Thiosemicarbazide derivatives such as: 1-(amino-N-phenylmethanethio)-4-(pyridine-2-yl)thiosemicarbazide (H2PPS), N ...
Yousef, Tarek Mohamed, Abu El-Reash, Gaber Mohamed, Ola Ahmed Al-Gammal, Al-Gammal, Ola Ahmed, Shaban El-Sayed Ghazy, Ghazy, Shaban El-Sayed, Gaber Mohamed Abu El-Reash, Tarek Mohamed Yousef   +7 more
core   +1 more source

Microwave-Assisted Synthesis of New N1,N4-Substituted Thiosemicarbazones

Molecules, 2011
We present an efficient procedure for the synthesis of thirty-six N1,N4-substituted thiosemicarbazones, including twenty-five ones that are reported for the first time, using a microwave-assisted methodology for the reaction of thiosemicarbazide ...
Aurea Echevarria, Danilo Sousa Pereira, Lucimar Ferreira Kneipp, Rojane de Oliveira Paiva, Camilla Moretto dos Reis   +4 more
doaj   +1 more source

Synthesis, In vitro Biological Studies of novel Homoleptic Ni(II) and Zn(II) Complexes of Thiosemicarbazide Derivative ligand [PDF]

, 2022
Thiosemicarbazide derivatives are currently becoming an important class of S, N –donor ligands to form stable metal complexes showing some biological applications.
Muleta, Fekadu
core  

Synthetical Application of Alkyl 2-isothiocyanatocarboxylates. A Simple Synthesis of 5-Substituted-3-amino-2-thioxo-4-imidazolidinones (3-Amino-2-thiohydantoins)

Molecules, 1999
The title 3-amino-2-thiohydantoins 3 has been prepared in very good yields by the reaction of alkyl isothiocynatocarboxylates 1 with hydrazine hydrate.The synthesis of starting isothiocyanates as well as spectral data of 3-aminothiohydantoins and alkyl ...
Martin Kovac, Vladimir Oremus, Lubomir Floch   +2 more
doaj   +1 more source