Results 41 to 50 of about 5,992 (210)

Synthesis, docking and in-vitro screening of mannich bases of thiosemicarbazide for anti-fungal activity [PDF]

, 2013
Mannich bases and thiosemicarbazide individually show antimicrobial, antifungal, anticonvulsant, antimalarial, analgesic and anti-inflammatory type of varied pharmacological activities. The novelty of the present work is the synthesis of mannich bases of
More, Harinath N., Pishawikar, Sachin A.
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Study of the Relationships between the Structure, Lipophilicity and Biological Activity of Some Thiazolyl-carbonyl-thiosemicarbazides and Thiazolyl-azoles

Molecules, 2015
Lipophilicity, as one of the most important physicochemical parameters of bioactive molecules, was investigated for twenty-two thiazolyl-carbonyl-thiosemicarbazides and thiazolyl-azoles.
Radu Tamaian, Augustin Moţ, Radu Silaghi-Dumitrescu, Ioana Ionuţ, Anca Stana, Ovidiu Oniga, Cristina Nastasă, Daniela Benedec, Brînduşa Tiperciuc   +8 more
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Retention Behavior of Anticancer Thiosemicarbazides in Biomimetic Chromatographic Systems and In Silico Calculations

Molecules, 2023
Chromatographic methods, apart from in silico ones, are commonly used rapid techniques for the evaluation of certain properties of biologically active compounds used for their prediction of pharmacokinetic processes.
Marek Studziński, Paweł Kozyra, Monika Pitucha, Bogusław Senczyna, Joanna Matysiak   +4 more
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Coumarinyl Thiosemicarbazides as Antimicrobial Agents

Pharmaceutical Chemistry Journal, 2018
A two series of coumarinyl thiosemicarbazides were synthesized. One series derived from coumarin core substituted in position 7 and another from coumarin core substituted in position 4. All compounds were obtained in reaction of corresponding hydrazide and various isothiocyanates.
Molnar, Maja, Tomić, Marinko, Pavić, Valentina   +2 more
openaire   +3 more sources

Microwave-Assisted Synthesis of New N1,N4-Substituted Thiosemicarbazones

Molecules, 2011
We present an efficient procedure for the synthesis of thirty-six N1,N4-substituted thiosemicarbazones, including twenty-five ones that are reported for the first time, using a microwave-assisted methodology for the reaction of thiosemicarbazide ...
Aurea Echevarria, Danilo Sousa Pereira, Lucimar Ferreira Kneipp, Rojane de Oliveira Paiva, Camilla Moretto dos Reis   +4 more
doaj   +1 more source

Synthetical Application of Alkyl 2-isothiocyanatocarboxylates. A Simple Synthesis of 5-Substituted-3-amino-2-thioxo-4-imidazolidinones (3-Amino-2-thiohydantoins)

Molecules, 1999
The title 3-amino-2-thiohydantoins 3 has been prepared in very good yields by the reaction of alkyl isothiocynatocarboxylates 1 with hydrazine hydrate.The synthesis of starting isothiocyanates as well as spectral data of 3-aminothiohydantoins and alkyl ...
Martin Kovac, Vladimir Oremus, Lubomir Floch   +2 more
doaj   +1 more source

Synthesis of Benzimidazole–Based Analogs as Anti Alzheimer’s Disease Compounds and Their Molecular Docking Studies

Molecules, 2020
We synthesized 10 analogs of benzimidazole-based thiosemicarbazide 1 (a–j) and 13 benzimidazole-based Schiff bases 2 (a–m), and characterized by various spectroscopic techniques and evaluated in vitro for acetylcholinesterase (AchE) and ...
Bushra Adalat, Fazal Rahim, Muhammad Taha, Foziah J. Alshamrani, El Hassane Anouar, Nizam Uddin, Syed Adnan Ali Shah, Zarshad Ali, Zainul Amiruddin Zakaria   +8 more
doaj   +1 more source

Pharmacophore Mapping Approach for Drug Target Identification: A Chemical Synthesis and in Silico Study on Novel Thiadiazole Compounds [PDF]

Journal of Clinical and Diagnostic Research, 2017
Introduction: Compounds containing thiadiazole moiety are cognized to possess with variety of clinical and therapeutic activity. Finding a suitable drug target for newly synthesized compounds remain a major bottle neck in current high throughout ...
Rohan J. Meshram, Vijay B. Baladhye, Rajesh N. Gacche, Bhausaheb K. Karale, Rajendra B. Gaikar   +4 more
doaj   +1 more source

Synthesis and Characterization of Novel Corrosion Inhibitor Derived from Oleic Acid: 2-Amino 5-Oleyl-1,3,4-Thiadiazol (AOT)

International Journal of Electrochemical Science, 2012
Novel corrosion inhibitor as a green chemical product namely derivative, 2-amino 5-oleyl-1,3,4-thiadiazol (AOT) was synthesized by cyclization of oleic acid. The new corrosion inhibitor was characterized by FT-IR and NMR spectroscopical methods.
Sutiana Junaedi, Abdul Amir H. Kadhum, Ahmed A. Al-Amiery, Abu Bakar Mohamad, Mohd Sobri Takriff   +4 more
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1,1,4-Derivatives of Thiosemicarbazide—New Non-Staining Antiozonants

, 1973
In the nature of non-staining antiozonants, a new class of compounds, 1,1,4-derivatives of thiosemicarbazide, are proposed. The mechanism of reaction of thiosemicarbazide derivatives with ozone is analogous to the mechanism of this reaction with thiourea
L. K. Zolotarevskaya, A. M. Lipkin, A. E. Grinberg, L. G. Angert   +3 more
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