Results 41 to 50 of about 8,827 (223)

Synthesis, Molecular Docking and Anticancer Activity of Diflunisal Derivatives as Cyclooxygenase Enzyme Inhibitors

Molecules, 2018
Cyclooxygenase enzymes play a vital role in inflammatory pathways in the human body. Apart from their relation with inflammation, the additional involvement of COX-2 enzyme with cancer activity was recently discovered.
Göknil Pelin Coşkun, Teodora Djikic, Taha Bartu Hayal, Nezaket Türkel, Kemal Yelekçi, Fikrettin Şahin, Ş. Güniz Küçükgüzel   +6 more
doaj   +1 more source

An Efficient and One Spot Synthesis of Silica Supported Synthesis of Fluorinated 1,3,4-Thiadiazole Derivative Under Microwave Irradiation

To Chemistry Journal, 2020
An efficient and one pot reaction of fluorinated 1,3,4-Thiadiazole derivatives  was synthesis by fluorinated  aromatic carboxylic with thiosemicabazide in the presence of phosphorus oxychloride as a catalyst under Microwave irradiation with silica ...
Bharat K Dhotre, Bhagwan Singh Dobhalb, Santosh Raut, Amol Kalea, Pathan Mohd Arif   +4 more
doaj   +2 more sources

Pharmacological and Structure-Activity Relationship Evaluation of 4-aryl-1-Diphenylacetyl(thio)semicarbazides [PDF]

, 2014
This article describes the synthesis of six 4-aryl-(thio)semicarbazides (series a and b) linked with diphenylacetyl moiety along with their pharmacological evaluation on the central nervous system in mice and computational studies, including ...
Fidecka, Sylwia, Kuśmierz, Edyta, Kędzierska, Ewa, Orzelska, Jolanta, Paneth, Agata, Paneth, Piotr, Plech, Tomasz, Wróbel, Andrzej, Wujec, Monika   +8 more
core   +2 more sources

A designed phenylalanyl-tRNA synthetase variant allows efficient in vivo incorporation of aryl ketone functionality into proteins [PDF]

, 2002
Incorporation of non-natural amino acids into proteins in vivo expands the scope of protein synthesis and design. p-Acetylphenylalanine was incorporated into recombinant dihydrofolate reductase (DHFR) in Escherichia coli via a computationally designed ...
Carrico, Isaac S., Datta, Deepshikha, Mayo, Stephen L., Tirrell, David A., Wang, Pin   +4 more
core   +2 more sources

Design, Synthesis, Antibacterial Evaluations and In Silico Studies of Novel Thiosemicarbazides and 1,3,4-Thiadiazoles

Molecules, 2022
The emergence of drug-resistant bacterial strains continues to be one of the major challenges of medicine. For this reason, the importance of searching for novel structures of antibacterial drugs chemically different from the currently known antibiotics ...
Sara Janowska, Dmytro Khylyuk, Sylwia Andrzejczuk, Monika Wujec   +3 more
doaj   +1 more source

A facile synthesis of N-Z/Boc-protected 1,3,4-oxadiazole-based peptidomimetics employing peptidyl thiosemicarbazides [PDF]

, 2010
Synthesis of 1,3,4-oxadiazole containing peptidomimetics is described by a p-TsCl/pyridine-mediated cyclization of the corresponding dipeptidyl thiosemicarbazides, which are readily prepared by coupling N-protected amino acid hydrazides with amino acid ...
Lamani, R.S., Nagendra, G., Sureshbabu, V.V.   +2 more
core   +1 more source

Recent Advances in Photocatalytic Urea Synthesis via C−N Coupling From C/N‐Containing Species: A Mini Review

EcoEnergy, EarlyView.
This review systematically compares photocatalytic urea synthesis from various C (CO2, CO, CH3OH) and N (N2, NH3, NO3−) sources. It highlights C–N coupling mechanisms, key challenges, and future directions, offering a framework to guide rational catalyst design for sustainable, solar‐driven urea production.
Bo Ding, Jicheng Chen, Hongji Liang, Xiang Yu, Wensheng Zhang, Dongxue Han   +5 more
wiley   +1 more source

UV-visible and $^1H-^{15}N$ NMR spectroscopic studies of colorimetric thiosemicarbazide anion sensors [PDF]

, 2015
Four model thiosemicarbazide anion chemosensors containing three N – H bonds, substituted with phenyl and/or 4-nitrophenyl units, were synthesised and studied for their anion binding abilities with hydroxide, fl uoride, acetate, dihydrogen phosphate
Agnieszka Podborska, Amendola, Amendola, Amendola, Amendola, Boiocchi, Boiochhi, Bonizzoni, Bordwell, Caltagirone, Cametti, Camiolo, Cho, Damjan Makuc, David C. Magri, de Silva, Duke, Duke, Duke, Esteban-Gómez, Esteban-Gómez, Evans, Evans, Gale, Gale, Gale, Gale, Gale, Gunnlaugsson, Gunnlaugsson, Gunnlaugsson, He, Janez Plavec, Konrad Szaciłowski, Kristina N. Farrugia, Kubik, Kubik, Li, Li, Li, Liu, Makuc, Makuc, Makuc, Makuc, Martin, Martínez-Máñez, Mason, Misra, Miyaji, Nie, Paduka Ali, Pandurangan, Pandurangan, Piela, Santos-Figueroa, Sessler, Shao, Suksai, Tetilla, Wenzel, Witanowski, Wu   +62 more
core   +1 more source

Occupational Exposure to Factory‐Derived Particulate Matter 2.5 Induces Cutaneous Toxicity in Workers and HaCaT Keratinocytes Through Oxidative Stress and Inflammation

Journal of Applied Toxicology, Volume 46, Issue 6, Page 2145-2157, June 2026.
ABSTRACT This study aimed to evaluate the toxicological effects of occupational exposure to factory‐derived particulate matter (PM2.5) on human skin, emphasizing its role as a potential target organ of environmental toxicants. An epidemiological survey comparing factory and nonfactory workers was conducted by assessing their skin elasticity and color ...
Miku Tanaka, Masayuki Takaishi, Iroha Okuda, Toshiki Fujimoto, Mayumi Tsuji, Yuri Okano, Yasuhiro Ishihara, Maori Kono   +7 more
wiley   +1 more source

Synthesis, Reactions and Antimicrobial Activities of 8-Ethoxycoumarin Derivatives

Molecules, 2012
Condensation of 3-acetyl-8-ethoxycoumarin (3) with thiosemicarbazide gave ethylidenehydrazinecarbothioamide 5, which was transformed into the thiazolidin-4-one derivatives 6,7. Interaction of 3 with DMF/POCl3 gave b-chloroacroline derivative 8. Treatment
Mostafa M. Khafagy, Ahmed H. Bedair, Fathy A. Eid, Kamal A. Ahmed, Ahmed M. El-Agrody, Hany M. Mohamed, Ashraf H. F. Abd El-Wahab   +6 more
doaj   +1 more source