1,4-disubstituted thiosemicarbazide derivatives are potent inhibitors of toxoplasma gondii proliferation. [PDF]
, 2014 A series of 4-arylthiosemicarbazides substituted at the N1 position with a 5-membered heteroaryl ring was synthesized and evaluated in vitro for T. gondii inhibition proliferation and host cell cytotoxicity.
Dzitko, Katarzyna +6 more
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Thiosemicarbazide Toxicity in Mice.
Experimental Biology and Medicine, 1952 Summary1. Fatal convulsions follow the administration of doses of 20 mg of thiosemicarbazide (TSC)/kg or more to mice. 2. Semicarbazide is approximately 1/20 as toxic as thiosemicarbazide, while aminoguanidine produces no toxic symptoms at a dose of 650 mg/kg. 3.
R E, PARKS, G W, KIDDER, V C, DEWEY
openaire +2 more sources
Investigation of the effects of magnesium orotate in a model of primary generalized seizures
Неврология, нейропсихиатрия, психосоматика, 2017 Objective: to investigate the anticonvulsant and neuroprotective effects of magnesium orotate in a rat thiosemicarbazide model of seizures in rats.Material and methods.
A. G. Kalacheva +6 more
doaj +1 more source
New bioactive 2,6-diacetylpyridine bis(p-chlorophenylthiosemicarbazone) ligand and its Pd(II) and Pt(II) complexes: Synthesis, characterization, cytotoxic activity and DNA binding ability [PDF]
, 2014 NOTICE: this is the author’s version of a work that was accepted for publication in Journal of Inorganic Biochemistry. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality ...
Hernández, Carolina +2 more
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Inhibitory effect of coumarin derivatives on apple (cv. Idared) polyphenol oxidase
Croatian Journal of Food Science and Technology, 2017 Inhibitory effect of 32 coumarin derivatives (20 Schiff bases, 5 thiosemicarbazides, 5 thiazolidinones, and their precursors, 7-hydroxy-4-methylcoumarin and 4-methylcoumarin-7-yl hydrazine carboxylate) on partially purified apple polyphenol oxidase was ...
I. Strelec +4 more
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Synthesis and Characterization of the Triazole Derived from Thiosemicarbazide, 4-Amino-5-Phenyl-4H-1,2,4- Triazole-3-Thiol and Their Copper(II) and Nickel(II) Complexes [PDF]
Engineering and Technology Journal, 2013 Triazole N-(3-mercapto-5-phenyl-4H-1,2,4-triazol-4-yl)hydrazinecarbothioamide prepared in good yield via the condensation of 4-amino-5-phenyl-4H-1,2,4-triazole-3-thiol and thiosemicarbazide.
Hamdan Abood Aday
doaj +1 more source
Palladium(II) and platinum(II) bis(thiosemicarbazone) complexes of the 2,6-diacetylpyridine series with high cytotoxic activity in cisplatin resistant A2780cisR tumor cells and reduced toxicity [PDF]
, 2013 NOTICE: this is the author’s version of a work that was accepted for publication in Journal of Inorganic Biochemistry. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality ...
Leitão, Inês +2 more
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A designed phenylalanyl-tRNA synthetase variant allows efficient in vivo incorporation of aryl ketone functionality into proteins [PDF]
, 2002 Incorporation of non-natural amino acids into proteins in vivo expands the scope of protein synthesis and design. p-Acetylphenylalanine was incorporated into recombinant dihydrofolate reductase (DHFR) in Escherichia coli via a computationally designed ...
Carrico, Isaac S. +4 more
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3,5-Diacetyl-1,2,4-triazol bis( 4N-substituted thiosemicarbazone) palladium(II) complexes: Synthesis, structure, antiproliferative activity and low toxicity on normal kidney cells [PDF]
, 2011 this is the author’s version of a work that was accepted for publication in Journal of Inorganic Biochemistry. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control ...
Hernández, Carolina +3 more
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Synthesis and biological evaluation of anti-Toxoplasma gondii activity of a novel scaffold of thiazolidinone derivatives [PDF]
, 2017 We designed and synthesised novel N-substituted 1,3-thiazolidin-4-one derivatives for the evaluation of their anti-Toxoplasma gondii efficacy. This scaffold was functionalised both at the N1-hydrazine portion with three structurally different moieties ...
Bizzarri, Bruna +9 more
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