Results 71 to 80 of about 5,263 (174)

Antidiabetic and Cytotoxicity Studies of Novel Quinazolinone–1,3,4‐Thiadiazole Molecular Hybrids

Chemistry &Biodiversity, Volume 23, Issue 5, May 2026.
ABSTRACT In the treatment of diabetes mellitus (DM), inhibition of carbohydrate‐hydrolysing enzymes, such as α‐amylase, has emerged as a promising therapeutic strategy. In the present study, a series of quinazolinone‐1,3,4‐thiadiazole molecular hybrids were designed, synthesized and biologically evaluated for their antidiabetic potential.
Prishani Kisten, Pule Seboletswe, Gobind kumar, Nontobeko Gcabashe, Neha Manhas, Ankit, Almahi Idris, Md. Shahidul Islam, René Khan, Parvesh Singh   +9 more
wiley   +1 more source

1-(Biphenyl-4-ylmethylidene)thiosemicarbazide monohydrate [PDF]

, 2010
In the title compound, C14H13N3S·H2O, the thiosemicarbazide group is nearly planar, with a maximum deviation of 0.072 (2) Å from the ideal least-squares plane, and shows an E conformation. In the crystal packing, the
Laura Menéndez-Taboada, Menéndez Taboada, Laura, Fernández Zapico, Eva, Menéndez-Taboada, Laura, Santiago García-Granda, García-Granda, Santiago, Mendoza-Meroño, Rafael, Mendoza Meroño, Rafael, Rafael Mendoza-Meroño, Eva Fernández-Zapico, Fernández-Zapico, E.   +10 more
core   +1 more source

Antidiabetic Evaluation of Thiosemicarbazone Analogs Through α‐Amylase Inhibition Complemented With Computational Studies

Chemistry &Biodiversity, Volume 23, Issue 5, May 2026.
Thiosemicarbazones were evaluated for antidiabetic activity via α‐amylase inhibition. Compound 6g showed two‐fold greater potency than acarbose. Benzaldehyde‐ and ketone‐derived analogues were most active, while isatin and furan derivatives were less effective. Several compounds displayed antioxidant activity. Docking highlighted hydrogen bonding and π–
Neha Manhas, Gobind Kumar, Ankit, Nagaraju Kerru, Pule Seboletswe, Nontobeko Gcabashe, Almahi Idris, Md. Shahidul Islam, Talent Makhanya, Parvesh Singh   +9 more
wiley   +1 more source

Growth and characterization of thiosemicarbazide hydrochloride: A semiorganic NLO material

, 2011
Thiosemicarbazide hydrochloride (TSCHCL) was synthesized by mixing thiosemicarbazide and hydrochloride in 1:1 molar ratio in double distilled water. Single crystals of TSCHCL were grown by slow evaporation at room temperature and were characterized by ...
Ramamurthi, K., R. Ramesh Babu, R. Santhakumari, Santhakumari, R., Hema, R., Helen Stoeckli Evans, Bhagavannarayana , G., R. Hema, K. Ramamurthi, G. Bhagavannarayana, Babu, R. Ramesh, Evans , Helen Stoeckli   +11 more
core   +1 more source

Versatile coordination chemistry of thiosemicarbazide and its non-Schiff base derivatives

Very rich coordination chemistry of thiosemicarbazide based ligands is mainly associated with the diversity of their Schiff base derivatives, known as thiosemicarbazones.
Leovac, Vukadin M., Novaković, Slađana B.   +1 more
core   +1 more source

Photosubstitution of Thiosemicarbazide to VI B and VII B Group Metal Carbonyls

, 2013
A series of new metal carbonyl complexes of VIB and VIIB groups having the general compositions cis-[M(CO)(4)(eta(2)-N,S,-TSC], [M = Cr; 1, Mo; 2, W; 3] and fac-[ReBr(CO)(3) (eta(2)-N,N,TSC)], 4 and [(eta(2)-N,N-TSC)], 5 have been prepared by ...
Cetin, S., S. Çetin, E. Subasi, Subasi, ELİF   +3 more
core   +1 more source

(E)-1-[(2-Chloro-5-methylpyridin-3-yl)methylene]thiosemicarbazide

, 2010
The title compound, C8H9ClN4S, which has potential insecticidal activity, was synthesized by the reaction of 2-chloro-5-methylnicotinaldehyde and thiosemicarbazide.
Zhen Wang, Zhen Wang, Yongqiang Ma, Yun Ling, Xinling Yang, Yan Xu   +5 more
core   +1 more source

Dodecanoyl thiosemicarbazide derivatives as useful synthons in the synthesis of 1,2,4-triazole, 1,3,4-thiadiazole, and 1,3-benzothiazole derivatives

, 2016
A convenient synthesis of the dodecanoyl thiosemicarbazide derivatives 3a, b has been achieved from the reaction of 2-benzamido-3-arylacryloylhydrazides 1a, b and lauroyl isothiocyanate (2).
Sandy S. Samy (2581717), Ahmed S. A. Youssef (2581723), Magdy M. Hemdan (2581726), Wael S. I. Abou Elmagd (2581720)   +3 more
core   +1 more source

Reaction of N-alkylisatins with 4-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)thiosemicarbazide [PDF]

, 2013
Some N-alkylisatins were converted to corresponding thiosemicarbazones by reaction with 4-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)thiosemicarbazide using microwave-assisted heating method.
Nguyen Dinh Thanh, Nguyen Thi Kim Giang
core   +1 more source