Results 81 to 90 of about 6,253 (217)

Design, Synthesis, and Investigation of the Biological Activities of New Thiadiazole Derivatives With Anticancer Effects

Chemical Biology &Drug Design, Volume 108, Issue 3, September 2026.
In silico studies reveal that compound 3c interacts strongly with the active site of the aromatase enzyme. In addition, compound 3c yielded promising results in in vitro enzyme inhibition and cytotoxicity studies. ABSTRACT Breast cancer is one of the most significant diseases in today's world.
Yusuf Özkay, Enes Bal, Berkant Kurban, Derya Osmaniye, Begüm Nurpelin Sağlık Özkan, Zafer Asım Kaplancıklı   +5 more
wiley   +1 more source

Hematite (α‐Fe2O3) Nanoparticles Conjugated with Thiosemicarbazones: Hydrothermal‐Assisted Synthesis, Characterization, Antibacterial, Antioxidant, and Photocatalytic Activities [PDF]

Chem Biodivers
The study describes the functionalization of α‐Fe2O3 nanoparticles with three different thiosemicarbazone ligands through a hydrothermal route. The nanoconjugates were tested for their antibacterial and antioxidant activities, and their photocatalytic potential was tested against malachite green dye.
Veg E, Dwivedi S, Rai S, Sharma S, Fatima N, Joshi S, Khan A, Khan T.   +7 more
europepmc   +2 more sources

Pyridyl‐Thiazole‐Thiosemicarbazones as Antitrypanosomatidae Agents: Design, Synthesis, and In Silico Profiling

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
A novel pyridine–thiazole derivative, Compound 8, exhibited potent dual antitrypanosomatid activity. It demonstrated remarkable in vitro efficacy against Trypanosoma cruzi (IC50 = 1.0 µM) and L. amazonensis (IC50 = 3.9 µM). Molecular docking studies suggested interactions with heme and multiple molecular targets.
Anderson José Firmino Santos da Silva, Daiane Santiago da Cruz Olimpio, Lucas Manoel da Silva Sousa, Graziella Leite Brondani, Tacylla Lima Silva, Wéllyda Belmira de Lira Silva, Natáli Tereza Capistrano Costa, Marcelo Zaldini Hernandes, Policarpo Ademar Sales Junior, Valéria Rêgo Alves Pereira, Ana Cristina Lima Leite   +10 more
wiley   +1 more source

Nanosilica-supported thiosemicarbazide–glutaraldehyde polymer for selective Au(iii) removal from aqueous solution

, 2017
A thiosemicarbazide/nanosilica composite exhibited significant uptake toward Au(iii). Adsorption isotherms and kinetics revealed a synergistic effect of ionic interaction and chelation exists between Au(iii) and the synthesized nanocomposites.
Zhao Ding, Gengwei Zhang, Yang Zhou, Likang Fu, Shixing Wang   +4 more
core   +1 more source

Recent Advances in Fluorescent Probes for Imaging Enzyme Activity in NETosis

ChemBioChem, Volume 27, Issue 15, 14 August 2026.
Fluorescent probes enable real‐time visualization of neutrophil effector functions. This review summarizes current probe design strategies and emerging tools for imaging key enzymatic activities, with emphasis on mechanisms underlying NETosis, a lytic form of neutrophil extracellular trap (NET) formation. We discuss current limitations, challenges, and
Enebie Ramos Cáceres, Marijn J. Hollander, Kimberly M. Bonger   +2 more
wiley   +1 more source

(3aR,6R)-3,3,6-Trimethyl-3,3a,4,5,6,7-hexahydro-2H-indazole-2-carbothioamide

IUCrData, 2016
The title compound, C11H19N3S, was prepared by the reaction of (R)-pulegone with thiosemicarbazide in acidic medium, using ethanol as solvent. The molecule is built up from fused six and five-membered rings.
Abdellah N'Ait Ousidi, My Youssef Ait Itto, Aziz Auhmani, Abdelkhalek Riahi, Sylviane Chevreux, Moha Berraho   +5 more
doaj   +1 more source

Effect of substituents on corrosion inhibition efficiency of arylisothiocyanates and their condensation products with thiosemicarbazide for corrosion of copper in aqueous chloride solution

, 2003
414-419The inhibition of copper corrosion in 1.5% sodium chloride solution was studied at 25, 35 and 45°C using different concentrations of thiosemicarbazide, p-methoxyphenyl isothiocyanate, p-methylphenyl isothiocyanate and p-chlorophenyl ...
Rastogi, R B, Singh, M M, Upadhyay, B N, Yadav, M   +3 more
core  

Design, Synthesis, and Fungicidal Activity of Novel Thiosemicarbazide Derivatives Containing Piperidine Fragments

Molecules, 2017
In order to discover novel eco-friendly lead compounds for plant pathogenic fungi control, a series of benzaldehyde thiosemicarbazide derivatives with a piperidine moiety have been designed and synthesized.
Xuebo Zhang, Peng Lei, Tengda Sun, Xiaoyu Jin, Xinling Yang, Yun Ling   +5 more
doaj   +1 more source

Kinetics and mechanism of the interaction of thiosemicarbazide with di-μ-hydroxo bis(bipyridyl)dipalladium(II) ion

, 2002
1188-1190Kinetics of interaction between thiosemicarbazide with the title complex has been studied spectrophotometrically as a function of [Pd2(bipy)2(OH)22+], [thiosemicarbazide], pH and temperature.
Moi, Sankar Chandra, De, G S, Ghosh, A K
core  

(E)-1-[(2-Chloro-5-methylpyridin-3-yl)methylene]thiosemicarbazide

, 2010
The title compound, C8H9ClN4S, which has potential insecticidal activity, was synthesized by the reaction of 2-chloro-5-methylnicotinaldehyde and thiosemicarbazide.
Zhen Wang, Zhen Wang, Yongqiang Ma, Yun Ling, Xinling Yang, Yan Xu   +5 more
core   +1 more source