Results 81 to 90 of about 8,698 (205)

Therapeutic Reprogramming of Glioblastoma Phenotypic States Using Multifunctional Heparin Nanoparticles

Advanced Science, Volume 13, Issue 3, 14 January 2026.
This study presents heparin‐derived nanoparticles (HP‐NPs) as a novel precision medicine platform that combines therapeutic and delivery functions. HP‐NPs target drug‐resistant glioblastoma stem cells, reprogramming them into a drug‐sensitive phenotype and significantly reducing tumor progression.
Vadim Le Joncour, Austin D. Evans, Camilla Karoliina Bergström, Vignesh Kumar Rangasami, Sumanta Samanta, Nithiyanandan Krishnan, Yuji Teramura, Bo Nilsson, Patricia Hedenqvist, Elin Manell, Jons Hilborn, Marianne‐Jensen Waern, Oommen P. Varghese, Pirjo Laakkonen, Oommen P. Oommen   +14 more
wiley   +1 more source

A Multifunctional Polar Amino Acid for Mixed Tin‐Lead Perovskites and All‐Perovskite Tandems

Advanced Science, Volume 13, Issue 6, 30 January 2026.
AsnCl improves film orientation and crystallinity, suppresses Sn4+ and PbI2 defects, and prolongs carrier lifetimes, enabling a 22.54% efficiency and enhanced stability in Sn–Pb perovskite solar cells. The AsnCl‐treated tandem device achieves a steady‐state PCE of 28.24%, underscoring the effectiveness of additive molecular engineering for high ...
Jin Zhou, Hongsen Cui, Chen Wang, Dexin Pu, Lishuai Huang, Shun Zhou, Guang Li, Qingxian Lin, Shining Zhang, Weiqing Chen, Guojia Fang, Weijun Ke, Weiwei Meng   +12 more
wiley   +1 more source

Butylated Hydroxytoluene Analogs: Synthesis and Evaluation of Their <em>Multipotent </em>Antioxidant Activities

Molecules, 2012
A computer-aided predictions of antioxidant activities were performed with the Prediction Activity Spectra of Substances (PASS) program. Antioxidant activity of compounds <strong>1</strong>, <strong>3</strong>, <strong>4</
Wageeh A. Yehye, Noorsaadah Abdul Rahman, Abeer A. Alhadi, Hamid Khaledi, Ng Seik Weng, Azhar Ariffin   +5 more
doaj   +1 more source

Trypanosoma equiperdum in the horse : a neglected threat? [PDF]

, 2018
Dourine is a contagious disease caused by Trypanosoma equiperdum that is transmitted directly from animal to animal during coitus. Dourine is known as an important disease in many countries, and it threatens equidae worldwide.
Ahmed, Y, Duchateau, Luc, Goddeeris, Bruno, Govaere, Jan, Hagos, A, Merga, B, Van Soom, Ann   +6 more
core  

Synthesis, Crystal Structure, Antioxidant, Antimicrobial, and Mutagenic Activities and DNA Interaction Studies of Ni(II) Schiff Base 4-Methoxy-3-Benzyloxybenzaldehyde Thiosemicarbazide Complexes [PDF]

, 2013
Three new Ni(II) square planar complexes of 4-methoxy-3-benzyloxybenzaldehyde thiosemicarbazide(4m3BTSC) having polypyridyl bases of general formulation [ML2] (1) and [MLB] (2, 3), where L = 4m3BTSC and B is N,N-donor heterocyclic bases, namely, 1,10 ...
Aradhya, M.S., Chetana, P.R., Policegoudra, R.S., Ramakrishna Rao, ., Somashekar, M.N., Srinatha, B.S.   +5 more
core   +1 more source

New Quinoline Kinase Inhibitors With Good Selectivity for NAK Kinases and Anti‐Tumor Activity Against Ewing Sarcoma

Archiv der Pharmazie, Volume 359, Issue 1, January 2026.
Focusing on the discovery of new therapeutics for childhood cancer, novel quinoline derivatives were synthesized and demonstrated activity against Ewing sarcoma. A target search was performed against a panel of kinases, and the compounds showed selectivity for the NAK family, mainly GAK, which was confirmed by enzyme kinetic assays.
Caroline de Bem Gentz, Thais Helena Maciel Fernandes, Marcela Silva Lopes, Lewis Elson, Andreas Krämer, Lucas Rodrigo de Souza, Isadora Serraglio Fortes, Geórgia Silva Pinto, Martha Cestari Silva Martins, Henrique Barros de Lima, André da Silva Santiago, Lauro José Gregianin, Katlin Brauer Massirer, Mário Henrique Bengtson, Rafael Roesler, Stefan Knapp, Stefan A. Laufer, Saulo Fernandes de Andrade   +17 more
wiley   +1 more source

Synthesis, In Vitro Screening and Docking Studies of New Thiosemicarbazide Derivatives as Antitubercular Agents

Molecules, 2019
A series of thiosemicarbazide derivatives was designed and synthesized by reaction of carboxylic acid hydrazide with isothiocyanates. The molecular structures of the investigated thiosemicarbazides were confirmed and characterized by spectroscopic ...
Monika Pitucha, Zbigniew Karczmarzyk, Marta Swatko-Ossor, Waldemar Wysocki, Maciej Wos, Kamil Chudzik, Grazyna Ginalska, Andrzej Fruzinski   +7 more
doaj   +1 more source

Synthesis and anti-Aphid Aphis gossypii (Glover) activity of some new quinoline derivatives [PDF]

, 2010
A series of quinoline derivatives have been elaborated fromreaction of 2-(m- and p-acetylanilino)-quinolines 6a-b withaldehydes under Claisen-Schmidt conditions followed by cyclization with phenyl hydrazine and hydroxylamine.
El Kafafy, Abdel Kader, El-Mageed, Ahmed, Mohamed, Aly, Nawwar, Galal   +3 more
core  

Targetability of hyaluronic acid nanogel to cancer cells: In vitro and in vivo studies [PDF]

, 2017
We have, in previous work developed, characterized and evaluated the biocompatibility of an engineered hyaluronic acid nanogel. Here we assess the targetability of a hyaluronic acid nanogel towards CD44 overexpressing cells, in vitro and in vivo. Results
Correia, A., Gama, F. M., Pedrosa, Sílvia S., Pereira, Paula   +3 more
core   +1 more source

Decoding Urease Inhibition: A Comprehensive Review of Inhibitor Scaffolds

ChemMedChem, Volume 21, Issue 2, January 2026.
Representative functional groups known for urease inhibition are reviewed within diverse scaffolds using structure–activity analyses to identify features associated with high inhibitory activity. Urease is a metalloenzyme produced by a wide range of organisms and plays a critical role in nitrogen microbial metabolism by catalyzing the hydrolysis of ...
Nuno Martinho, Natália Aniceto
wiley   +1 more source