Results 1 to 10 of about 884,760 (321)

Application of third-generation sequencing to herbal genomics [PDF]

Frontiers in Plant Science, 2023
There is a long history of traditional medicine use. However, little genetic information is available for the plants used in traditional medicine, which limits the exploitation of these natural resources. Third-generation sequencing (TGS) techniques have
Longlong Gao, Wenjie Xu, Tianyi Xin, Jingyuan Song   +3 more
doaj   +5 more sources

Next-Generation Sequencing (NGS) and Third-Generation Sequencing (TGS) for the Diagnosis of Thalassemia

Diagnostics, 2023
Thalassemia is one of the most heterogeneous diseases, with more than a thousand mutation types recorded worldwide. Molecular diagnosis of thalassemia by conventional PCR-based DNA analysis is time- and resource-consuming owing to the phenotype ...
Syahzuwan Hassan, Rosnah Bahar, Muhammad Farid Johan, Ezzeddin Kamil Mohamed Hashim, Wan Zaidah Abdullah, Ezalia Esa, Faidatul Syazlin Abdul Hamid, Zefarina Zulkafli   +7 more
doaj   +4 more sources

Identification of rare thalassemia variants using third-generation sequencing

Frontiers in Genetics, 2023
Routine PCR, Sanger sequencing, and specially designed GAP-PCR are often used in the genetic analysis of thalassemia, but all these methods have limitations.
Qin Liu, Qianting Chen, Zonglei Zhang, Shiyi Peng, Jing Liu, Jialun Pang, Zhengjun Jia, Hui Xi, Jiaqi Li, Libao Chen, Yinyin Liu, Ying Peng   +11 more
doaj   +4 more sources

Benchmarking second and third-generation sequencing platforms for microbial metagenomics

Scientific Data, 2022
Measurement(s) mock community • Metagenomic profiling Technology Type(s) Illumina HiSeq 3000 • ThermoFisher Ion Proton and GeneStudio S5 • MGI DNBseq G400 and T7 • Oxford Nanopore Sequencing • PacBio Sequel System • Genome mapping and assembly Sample ...
Victoria Meslier, Benoit Quinquis, Kévin Da Silva, Florian Plaza Oñate, Nicolas Pons, Hugo Roume, Mircea Podar, Mathieu Almeida   +7 more
doaj   +6 more sources

Viral oncogenes, viruses, and cancer: a third-generation sequencing perspective on viral integration into the human genome [PDF]

Frontiers in Oncology, 2023
The link between viruses and cancer has intrigued scientists for decades. Certain viruses have been shown to be vital in the development of various cancers by integrating viral DNA into the host genome and activating viral oncogenes.
Ruichen Ye, Ruichen Ye, Ruichen Ye, Angelina Wang, Brady Bu, Pengxiang Luo, Wenjun Deng, Xinyi Zhang, Shanye Yin, Shanye Yin   +9 more
doaj   +3 more sources

The Third-Generation Sequencing Challenge: Novel Insights for the Omic Sciences [PDF]

Biomolecules
The understanding of the human genome has been greatly improved by the advent of next-generation sequencing technologies (NGS). Despite the undeniable advantages responsible for their widespread diffusion, these methods have some constraints, mainly ...
Carmela Scarano, Iolanda Veneruso, Rosa Redenta De Simone, Gennaro Di Bonito, Angela Secondino, Valeria D’Argenio   +5 more
doaj   +3 more sources

Analysis of rare thalassemia genetic variants based on third-generation sequencing [PDF]

Scientific Reports, 2022
Thalassemia is a group of common hereditary anemias that cause significant morbidity and mortality worldwide. However, precisely diagnosing thalassemia, especially rare thalassemia variants, is still challenging.
Cuiting Peng, Haixia Zhang, Jun Ren, Han Chen, Ze Du, Tong Zhao, Aiping Mao, Ruofan Xu, Yulin Lu, He Wang, Xinlian Chen, Shanling Liu   +11 more
doaj   +4 more sources

Comprehensive comparison of the third-generation sequencing tools for bacterial 6mA profiling. [PDF]

Nat Commun
DNA N6-methyladenine (6mA) serves as an intrinsic and principal epigenetic marker in prokaryotes, impacting various biological processes. To date, limited advanced sequencing technologies and analyzing tools are available for bacterial DNA 6mA.
Lu B, Guo Z, Liu X, Ni Y, Xu L, Huang J, Li T, Feng T, Li R, Deng X.   +9 more
europepmc   +2 more sources

Comprehensive and deep evaluation of structural variation detection pipelines with third-generation sequencing data. [PDF]

Genome Biol
Structural variation (SV) detection methods using third-generation sequencing data are widely employed, yet accurately detecting SVs remains challenging. Different methods often yield inconsistent results for certain SV types, complicating tool selection
Liu Z, Xie Z, Li M.
europepmc   +2 more sources

When Livestock Genomes Meet Third-Generation Sequencing Technology: From Opportunities to Applications. [PDF]

Genes (Basel)
Third-generation sequencing technology has found widespread application in the genomic, transcriptomic, and epigenetic research of both human and livestock genetics.
Liu X, Zheng J, Ding J, Wu J, Zuo F, Zhang G.   +5 more
europepmc   +2 more sources