Results 11 to 20 of about 574,833 (290)
3GOLD: optimized Levenshtein distance for clustering third-generation sequencing data [PDF]
BMC Bioinformatics, 2022 Background Third-generation sequencing offers some advantages over next-generation sequencing predecessors, but with the caveat of harboring a much higher error rate. Clustering-related sequences is an essential task in modern biology.
Robert Logan +6 more
doaj +3 more sources
Benchmarking second and third-generation sequencing platforms for microbial metagenomics
Scientific Data, 2022 Measurement(s) mock community • Metagenomic profiling Technology Type(s) Illumina HiSeq 3000 • ThermoFisher Ion Proton and GeneStudio S5 • MGI DNBseq G400 and T7 • Oxford Nanopore Sequencing • PacBio Sequel System • Genome mapping and assembly Sample ...
Victoria Meslier +7 more
doaj +5 more sources
Recovery of human gut microbiota genomes with third-generation sequencing [PDF]
Cell Death and Disease, 2021 Human gut microbiota modulates normal physiological functions, such as maintenance of barrier homeostasis and modulation of metabolism, as well as various chronic diseases including type 2 diabetes and gastrointestinal cancer. Despite decades of research,
Yanfei Li +8 more
doaj +3 more sources
Diagnostic value of third-generation nanopore sequencing in extrapulmonary tuberculosis
Frontiers in Cellular and Infection MicrobiologyBackgroundThis study aimed to explore the accuracy of third-generation nanopore sequencing to diagnose extrapulmonary tuberculosis (EPTB).MethodsSamples were collected from the lesions of 67 patients with suspected EPTB admitted between April 2022 and ...
Chang Song +11 more
doaj +3 more sources
Analysis of rare thalassemia genetic variants based on third-generation sequencing [PDF]
Scientific Reports, 2022 Thalassemia is a group of common hereditary anemias that cause significant morbidity and mortality worldwide. However, precisely diagnosing thalassemia, especially rare thalassemia variants, is still challenging.
Cuiting Peng +11 more
doaj +3 more sources
Third‐Generation Sequencing of Epigenetic DNA
Angewandte Chemie, 2023 AbstractThe discovery of epigenetic bases has revolutionised the understanding of disease and development. Among the most studied epigenetic marks are cytosines covalently modified at the 5 position. In order to gain insight into their biological significance, the ability to determine their spatiotemporal distribution within the genome is essential ...
Bethany Searle +3 more
openaire +4 more sources
A window into third generation sequencing [PDF]
Human Molecular Genetics, 2010 First- and second-generation sequencing technologies have led the way in revolutionizing the field of genomics and beyond, motivating an astonishing number of scientific advances, including enabling a more complete understanding of whole genome sequences and the information encoded therein, a more complete characterization of the methylome and ...
Eric E, Schadt +2 more
openaire +3 more sources
Fertility & Reproduction, 2023 Background and Aims: In in vitro fertilization (IVF) cycles, some patients suffering with vaginosis showed poor reproductive outcome even transferring with good quality embryos.
Wei-Fang Chang +11 more
doaj +1 more source
Jabba: hybrid error correction for long sequencing reads using maximal exact matches [PDF]
, 2015 Third generation sequencing platforms produce longer reads with higher error rates than second generation sequencing technologies. While the improved read length can provide useful information for downstream analysis, underlying algorithms are challenged
Audenaert, P. +4 more
core +1 more source
Third generation indexing for third generation sequencing [PDF]
, 2020 AbstractIndexing of DNA sequences is the art of sorting massive genomic data in a user-friendly structure to enable rapid accessing and comparing of different patterns in the data. Current genome assemblers use general algorithms for string indexing that do not exploit the special structural arrangement of genomes.
openaire +1 more source