Results 101 to 110 of about 574,833 (290)
Structural variant calling using third-generation sequencing data
, 2021 Structural variants, commonly defined as genomic differences larger than 50 bp, are an important research target due to their large size and great impact on human phenotype and disease. Their unique properties and the weaknesses of traditional short-read sequencing technologies, however, complicate their detection and comprehensive characterization ...
openaire +3 more sources
BM-BC: A Bayesian Method of Base Calling for Solexa Sequence Data [PDF]
, 2012 Base calling is a critical step in the Solexa next-generation sequencing procedure. It compares the position-specific intensity measurements that reflect the signal strength of four possible bases (A, C, G, T) at each genomic position, and outputs ...
Jara, Alejandro +7 more
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Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
The use of sequencing information in software specification for verification [PDF]
, 1983 Software requirements specifications, virtual machine definitions, and algorithmic design all place constraints on the sequence of operations that are permissible during a program's execution.
Osterweil, Leon J., Taylor, Richard N.
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Very small deletions within the NESP55 gene in pseudohypoparathyroidism type 1b
, 2014 Pseudohypoparathyroidism (PHP) is caused by reduced expression of genes within the GNAS cluster, resulting in parathormone resistance. The cluster contains multiple imprinted transcripts, including the stimulatory G protein α subunit (Gs-α) and NESP55 ...
Mackay, Deborah J.G. +5 more
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Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
International Aquatic Research, 2018 To determine changes in bacterial composition in skin ulcerations in farmed sea cucumber Apostichopus japonicus, full-length 16S rRNA gene sequencing of different skin samples of A.
Yi Yang, Yuchun Li, Zhenlin Liang
doaj +1 more source
Recent progress in atomistic simulation of electrical current DNA sequencing
, 2014 We review recent advances in the DNA sequencing based on the measurement of transverse electrical currents. Device configurations proposed in the literature are classified according to whether the molecular fingerprints appear as the major (Mode I) or ...
Kim, Han Seul, Kim, Yong-Hoon
core +1 more source
PAFFT: A new homology search algorithm for third-generation sequencers
Genomics, 2015 DNA sequencers that can conduct real-time sequencing from a single polymerase molecule are known as third-generation sequencers. Third-generation sequencers enable sequencing of reads that are several kilobases long. However, the raw data generated from third-generation sequencers are known to be error-prone.
Kazuharu Misawa, Ryo Ootsuki
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