Results 101 to 110 of about 2,239,305 (281)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Water formation at low temperatures by surface O2 hydrogenation II: the reaction network

, 2010
Water is abundantly present in the Universe. It is the main component of interstellar ice mantles and a key ingredient for life. Water in space is mainly formed through surface reactions.
Acharyya, Acquista, Bandow, Baulch, Bockelée-Morvan, Boogert, C. Romanzin, Catalano, Cooper, Cuppen, Dulieu, Ehrenfreund, Gerakines, Giguère, H. Linnartz, H. M. Cuppen, Hiraoka, Ioppolo, Keyser, Khriachtchev, Lannon, Loeffler, Matar, Miyauchi, Mokrane, Oba, Orkin, Romanzin, S. Ioppolo, Sellevåg, Sivaraman, Tielens, Troe, Tsang, Tschersich, Tschersich, Whittet, Öberg, Öberg   +38 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

C₃-Alkylation of Imidazo[1,2-a]pyridines via Three-Component Aza-Friedel–Crafts Reaction Catalyzed by Y(OTf)₃

Molecules
As an important class of nitrogen-containing fused heterocyclic compounds, imidazo[1,2-a]pyridines often exhibit significant biological activities, such as analgesic, anticancer, antiosteoporosis, anxiolytic, etc.
Kai Yang, Cai-Bo Chen, Zhao-Wen Liu, Zhen-Lin Li, Yu Zeng, Zhao-Yang Wang   +5 more
doaj   +1 more source

A Novel Synthesis of Highly Functionalized Pyridines by a One-Pot, Three-Component Tandem Reaction of Aldehydes, Malononitrile and N-Alkyl-2-cyanoacetamides under Microwave Irradiation

Molecules, 2018
A convenient, fast and environmentally benign procedure for the synthesis of a new series of highly functionalized N-alkylated pyridines as privileged medicinal scaffolds was developed via a unique three-component reaction of easily available aromatic as
Ramadan Ahmed Mekheimer, Mariam Abdullah Al-Sheikh, Hanadi Yousef Medrasi, Najla Hosain Hassan Alsofyani   +3 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Modeling of carbon monoxide oxidation kinetics over NASA carbon dioxide laser catalysts [PDF]

The recombination of CO and O2 formed by the dissociation of CO2 in a sealed CO2 laser discharge zone is examined. Conventional base-metal-oxide catalysts and conventional noble-metal catalysts are not effective in recombining the low O2/CO ratio at the ...
Herz, Richard K.
core   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Structure near $K^-$+$p$+$p$ threshold in the in-flight $^3$He$(K^-,\Lambda p)n$ reaction

, 2016
To search for an S= -1 di-baryonic state which decays to $\Lambda p$, the $ {\rm{}^3He}(K^-,\Lambda p)n_{missing}$ reaction was studied at 1.0 GeV/$c$. Unobserved neutrons were kinematically identified from the missing mass $M_X$ of the $ {\rm{}^3He}(K^-,
:, Ajimura, S., Bazzi, M., Beer, G., Bhang, H., Bragadireanu, M., Buehler, P., Busso, L., Cargnelli, M., Choi, S., Collaboration, J-PARC E15, Curceanu, C., Doce, O. Vazquez, Enomoto, S., Faso, D., Fujioka, H., Fujiwara, Y., Fukuda, T., Guaraldo, C., Hashimoto, T., Hayano, R. S., Hiraiwa, T., Iio, M., Iliescu, M., Inoue, K., Ishiguro, Y., Ishikawa, T., Ishimoto, S., Ishiwatari, T., Itahashi, K., Iwai, M., Iwasaki, M., Kato, Y., Kawasaki, S., Kienle, P., Kou, H., Ma, Y., Marton, J., Matsuda, Y., Mizoi, Y., Morra, O., Nagae, T., Noumi, H., Ohnishi, H., Okada, S., Outa, H., Piscicchia, K., Sada, Y., Sakaguchi, A., Sakuma, F., Sato, M., Scordo, A., Sekimoto, M., Shi, H., Sirghi, D., Sirghi, F., Suzuki, K., Suzuki, S., Suzuki, T., Tanida, K., Tatsuno, H., Tokuda, M., Tomono, D., Toyoda, A., Tsukada, K., Vidal, A. Romero, Widmann, E., Wuenschek, B. K., Yamaga, T., Yamazaki, T., Yim, H., Zhang, Q., Zmeskal, J.   +72 more
core   +1 more source