Results 11 to 20 of about 109,215 (254)

Etiology and outcomes: Thrombotic microangiopathies in pregnancy. [PDF]

Res Pract Thromb Haemost, 2023
A State of the Art lecture titled "Etiology and Outcomes of Thrombotic Microangiopathies in Pregnancy" was presented at the International Society on Thrombosis and Haemostasis Congress in 2022.
Scully M, Neave L.
europepmc   +2 more sources

Epidemiology, Outcomes, and Complement Gene Variants in Secondary Thrombotic Microangiopathies. [PDF]

Clin J Am Soc Nephrol, 2023
Visual Abstract Background The identification of complement defects as major drivers of primary atypical hemolytic uremic syndrome (HUS) has transformed the landscape of thrombotic microangiopathies (TMAs), leading to the development of targeted ...
Werion A, Werion A, Storms P, Zizi Y, Beguin C, Bernards J, Cambier JF, Dahan K, Dierickx D, Godefroid N, Hilbert P, Lambert C, Levtchenko E, Meyskens T, Poiré X, van den Heuvel L, Claes KJ, Morelle J, UCLouvain TMA/HUS Network and KU Leuven TMA/HUS Network.   +18 more
europepmc   +2 more sources

Editorial: Thrombotic Microangiopathies, Diagnostic and Therapeutic Advances [PDF]

Frontiers in Medicine, 2021
Robert W. Maitta, Jay S. Raval, Hollie M. Reeves, Magali J. Fontaine   +3 more
doaj   +2 more sources

COVID-19 and thrombotic microangiopathies. [PDF]

Thromb Res, 2021
Severe COVID-19 can manifest as multiorgan dysfunction with pulmonary involvement being the most common and prominent. As more reports emerge in the literature, it appears that an exaggerated immune response in the form of unfettered complement ...
Tiwari NR, Phatak S, Sharma VR, Agarwal SK.   +3 more
europepmc   +2 more sources

Complement activation in secondary thrombotic microangiopathies. [PDF]

Nephrol Dial Transplant
Secondary thrombotic microangiopathies (TMAs) represent a heterogeneous group of diseases associated with a high risk of kidney failure and death despite available therapeutic strategies.
Morelle J, Caravaca-Fontan F, Fakhouri F, Frangou E, Bruchfeld A, Floege J, Mirioglu S, Moran SM, Steiger S, Stevens KI, Teng OYK, Aydin S, Java A, Timmermans SAMEG, Kronbichler A.   +14 more
europepmc   +2 more sources

Thrombotic microangiopathies assessment: mind the complement. [PDF]

Clin Kidney J, 2021
When faced with microangiopathic haemolytic anaemia, thrombocytopenia and organ dysfunction, clinicians should suspect thrombotic microangiopathy (TMA). The endothelial damage that leads to this histological lesion can be triggered by several conditions ...
Blasco M, Guillén E, Quintana LF, Garcia-Herrera A, Piñeiro G, Poch E, Carreras E, Campistol JM, Diaz-Ricart M, Palomo M.   +9 more
europepmc   +2 more sources

Thrombotic microangiopathies: First report of 294 cases from a single institution experience in Argentina [PDF]

EJHaem, 2021
Celia Dos Santos, Juvenal Paiva, Maria Fabiana Alberto   +2 more
exaly   +2 more sources

Immune-mediated thrombotic thrombocytopenic purpura plasma induces calcium- and IgG-dependent endothelial activation: correlations with disease severity

Haematologica, 2022
Immune-mediated thrombotic thrombocytopenic purpura (iTTP) is characterized by a severe ADAMTS13 deficiency due to the presence of anti-ADAMTS13 auto-antibodies, with subsequent accumulation of circulating ultra-large von Willebrand factor (VWF ...
Edwige Tellier, Agnès Widemann, Raphaël Cauchois, Julien Faccini, Marie Lagarde, Marion Brun, Philippe Robert, Stéphane Robert, Richard Bachelier, Pascale Poullin, Elien Roose, Karen Vanhoorelbeke, Paul Coppo, Françoise Dignat-George, Gilles Kaplanski   +14 more
doaj   +1 more source

MASP2 levels are elevated in thrombotic microangiopathies: association with microvascular endothelial cell injury and suppression by anti-MASP2 antibody narsoplimab. [PDF]

Clin Exp Immunol, 2021
Involvement of the alternative complement pathway (AP) in microvascular endothelial cell (MVEC) injury characteristic of a thrombotic microangiopathy (TMA) is well documented.
Elhadad S, Chapin J, Copertino D, Van Besien K, Ahamed J, Laurence J.   +5 more
europepmc   +2 more sources

A British Society for Haematology Guideline: Diagnosis and management of thrombotic thrombocytopenic purpura and thrombotic microangiopathies

British Journal of Haematology, 2023
The objective of this guideline is to provide healthcare professionals with clear, up‐to‐date and practical guidance on the management of thrombotic thrombocytopenic purpura (TTP) and related thrombotic microangiopathies (TMAs), including complement ...
M. Scully, R. Rayment, A. Clark, J. Westwood, T. Cranfield, R. Gooding, C. Bagot, A. Taylor, V. Sankar, D. Gale, T. Dutt, J. Mcintyre, W. Lester   +12 more
semanticscholar   +1 more source