Results 171 to 180 of about 132,893 (224)

Thromboxane B2 Production During Erection

Andrologia, 2009
The effect of erection on 6-keto-PGF1 alpha and thromboxane B2 in penile blood during electrically evoked erection was studied in the chacma baboon. 6-keto-PGF1 alpha remained at a low concentration, but thromboxane B2 showed a statistically significant rise 8-10 minutes after commencement of erection.
M S, Bornman, R C, Franz, D J, Jacobs, D J, Du Plessis   +3 more
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Radioimmunoassay of thromboxane B2 in horse plasma

Research in Veterinary Science, 1987
A radioimmunoassay for thromboxane B2 (TXB2) in unextracted horse plasma was evaluated. Sensitivity of the assay was 14.0 (SD 5.6) pg ml-1 of plasma. Interassay and intra-assay variation were 21.3 per cent and 4.3 per cent, respectively. The percentage of tracer bound in unextracted plasma in the absence of TXB2 was often higher than that in buffer ...
H, Cambridge, J A, Reynoldson, J D, Dunsmore, B J, Hilbert   +3 more
openaire   +2 more sources

Fractional conversion of thromboxane A2 and B2 to urinary 2,3-dinor-thromboxane B2 and 11-dehydrothromboxane B2 in the cynomolgus monkey

Biochimica et Biophysica Acta (BBA) - General Subjects, 1989
Following the intravenous administration of thromboxane (TX) B2, the stable hydration product of TXA2, to human and nonhuman primates the most abundant urinary metabolites are 2,3-dinor-TXB2 and 11-dehydro-TXB2. However, it is not known whether fractional conversion of TXB2 to its enzymatic metabolites is an accurate representation of TXA2 metabolism ...
PATRIGNANI, Paola, Morton H, Cirino M, Lord A, Charette L, Gillard J, Rokach J, Patrono C.   +7 more
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A chemiluminescent immunoassay for urinary thromboxane B2

Prostaglandins, 1991
Because of the vasoactive properties of thromboxane A2 and other related prostaglandins, much research has been conducted on drugs which alter their levels. Urinary levels of thromboxane B2 and 2,3-dinor thromboxane B2 (major urinary metabolite of thromboxane B2) are used as an indication of thromboxane production in-vivo.
A, Morello, S, Chang, A, Jacob, S J, Law, M, Stastny, L, Martin, A, Pamidi, A, Kotake   +7 more
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Thromboxane B2

1995
Thromboxane B2 is the stable but inactive breakdown product of the chemically unstable thromboxane A2, the powerful and physiologically active platelet aggregating agent and vasoconstrictor. Breakdown occurs non-enzymatically with a half-life of 3 minutes.
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Metabolism of thromboxane B2 in the cynomolgus monkey

Prostaglandins, 1977
[5,6,8,9,11,12,14,15-3H8]-Thromboxane B2 was injected into the saphenous vein of female cynomolgus monkeys, and blood samples were withdrawn from the contralateral saphenous vein. The compound was eliminated from the circulation with a half-life of about 10 min after an initial rapid disappearance.
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Tetranor thromboxane B2 is the principal urinary catabolite formed after I.V. infusion of thromboxane B2 in the rat

Biochemical and Biophysical Research Communications, 1980
Summary We report the isolation and structural elucidation of the major catabolite of Thromboxane B2 excreted in the urine of male adult Wistar rats into which tritium labeled TxB2 had been infused intravenously. The identity of this product as tetranor TxB2 was based on retention times on gas chromatography with radioactivity detection as well as ...
C R, Pace-Asciak, N S, Edwards
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Thromboxane B2 in borderline and essential hypertensive patients

Prostaglandins, Leukotrienes and Medicine, 1983
Thromboxane B2 (TxB2) was measured in the venous and arterial plasma and in the urine of 15 borderline and 15 sustained essential hypertensive patients, and in the plasma and urine of 12 control normotensive age-matched subjects. Plasma and urine thromboxane B2 were significantly higher in both the borderline and sustained hypertensives than in the ...
A, Hornych, M, Safar, J, Bariéty, A, Simon, G, London, J, Levenson   +5 more
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Radioimmunoassay of thromboxane B2 in plasma: Methodological modifications

Thrombosis Research, 1988
Thromboxane B2 (TxB2) determination is usually performed by using commercial 3H-RIA kits. However, the low amounts of TxB2 present in plasma are not detectable without previous extraction. The aim of this study is the evaluation of 1) plasma protein interferences on the binding and separation steps of bound from free analyte and 2) charcoal efficacy in
P G, Rogasi, R, Paniccia, M, Coppo, D, Prisco, M, Boddi, J, Chen, G F, Gensini, R, Abbate   +7 more
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Thromboxane B2 — comparative bronchoactivity in experimental systems

European Journal of Pharmacology, 1977
Abstract Thromboxane B2 (TxB2), a major product of prostaglandin endoperoxide metabolism, was examined quantitatively for bronchoactivity in the intact, anesthetized dog and on the isolated guinea pig trachea. In the dog, TxB2 (0.1 − 30.0 μg/kg i.v.) produced dose-related decreases in airflow rate, tidal volume and dynamic lung compliance, while ...
M A, Wasserman, R L, Griffin
openaire   +2 more sources